Protein Alignment Poxm and Pax8

DIOPT Version :10

• Sequence 1: NP_001036687.1
• Gene: Poxm / 40990
• FlyBaseID: FBgn0003129
• Length: 370
• Species: Drosophila melanogaster
• Sequence 2: NP_112403.2
• Gene: Pax8 / 81819
• RGDID: 620434
• Length: 457
• Species: Rattus norvegicus
• Alignment Length: 434
• Identity: 150/434 - (34%)
• Similarity: 190/434 - (43%)
• Gaps: 121/434 - (27%)

  Fly    10 YGEVNQLGGVFVNGRPLPNATRMRIVELARLGIRPCDISRQLRVSHGCVSKILARYHETGSILPG 74
            :|.:|||||.||||||||...|.|||:||..|:||||||||||||||||||||.||:|||||.||
  Rat    10 HGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPG 74

  Fly    75 AIGGSKPRVTTPKVVNYIRELKQRDPGIFAWEIRDRLLSEGICDKTNVPSVSSISRILRNKLG-- 137
            .||||||:|.|||||..|.:.|:::|.:||||||||||:||:||...|||||||:||:|.|:.
  Rat    75 VIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQP 139

  Fly   138 --------------SLGHQHTPGTVM----GSGSSSGGGSVSSNG-------GQNN------GTS 171
                          |.||...|.:.:    ...|.|.|.:.|.||       |.:|      ...
  Rat   140 FNLPMDSCVATKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQPGSDNKRKMDDSDQ 204

  Fly   172 ASNNINLSNLGNPGG----------GPHH------PHHHHHHQSAAAAASAHHVHAHAHAHAHLY 220
            .|..:::.:..:..|          |.||      |....|:..|.|:.|      |......||
  Rat   205 DSCRLSIDSQSSSSGPRKHLRTDTFGQHHLEPLECPFERQHYPEAYASPS------HTKGEQGLY 263

  Fly   221 -----NSIYQPYSAAAAYSMKTPCGSPSPPQGAGGQGSVPH-PHQLR-SVAAAAAAAHWPSSHSV 278
                 ||......|....| .||.|............:.|| |:.:: .....::::..|||.|.
  Rat   264 PLPLLNSTLDDGKATLTPS-NTPLGRNLSTHQTYPVVADPHSPYAIKQETPELSSSSSTPSSLSS 327

  Fly   279 SDILAHHQAVALRASCQVGVGVGGMGGMGSTVSP-----------------------------LP 314
            |..|...|             ||..|..|::|.|                             ||
  Rat   328 SAFLDLQQ-------------VGSGGPAGASVPPFNAFSHAASVYGQFTGQALLSGREMVGPTLP 379

  Fly   315 MTP-------------SPVAGTAGGQPLLDCEGGAGQQSPYNYY 345
            ..|             |.:||...|.   :..|.|...:||..|
  Rat   380 GYPPHIPTSGQGSYASSAIAGMVAGS---EYSGNAYSHTPYASY 420

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Poxm	NP_001036687.1	PAX	10..133	CDD:128645	88/122 (72%)
Pax8	NP_112403.2	PAX	9..133	CDD:128645	88/122 (72%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	12..68		42/55 (76%)
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	87..135		30/47 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	159..226		11/66 (17%)
		Pax2_C	344..456	CDD:463563	14/80 (18%)