DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Poxm and pax8

DIOPT Version :9

Sequence 1:	NP_001036687.1	Gene:	Poxm / 40990	FlyBaseID:	FBgn0003129	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	XP_012814730.1	Gene:	pax8 / 780226	XenbaseID:	XB-GENE-483693	Length:	467	Species:	Xenopus tropicalis

Alignment Length:	421	Identity:	147/421 - (34%)
Similarity:	196/421 - (46%)	Gaps:	102/421 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 YGEVNQLGGVFVNGRPLPNATRMRIVELARLGIRPCDISRQLRVSHGCVSKIL-ARYHETGSILP 73
            :|.:|||||.||||||||...|.|||:||..|:|||||||||||||||||||| :||:|||||.|
Frog    27 HGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGSRYYETGSIRP 91

  Fly    74 GAIGGSKPRVTTPKVVNYIRELKQRDPGIFAWEIRDRLLSEGICDKTNVPSVSSISRILRNKLGS 138
            |.||||||:|.|||||..|.:.|:::|.:||||||||||:||:||...|||||||:||:|.|:..
Frog    92 GVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQ 156

  Fly   139 LGH--------QHTPG-TVMGSG---------SSSGGGSVSSNG----------GQ---NNGTSA 172
            |.:        ..:|| |::.|.         |.|.|.:.|.:|          |:   ::....
Frog   157 LFNLPMESCVKSLSPGQTLIPSSAVTPPESPHSDSLGSTYSISGLLGITQPGADGKRKLDDSDQE 221

  Fly   173 SNNINLSNLGNPG---------GGPHHP------HHHHHHQSAAAAASAHHVHAHAHAHAHLYN- 221
            |..:::.:.|:.|         ...|||      |....|...:.::|.|.....|.....|.|
Frog   222 SCRLSIDSQGSMGISRKQLRTEAYGHHPLDALECHFQRQHFPESYSSSTHSKTEQALYTLPLLNN 286

  Fly   222 --------------------SIYQPYSA---AAAYSMKTPCGSPSPPQGAGGQGSVPHPHQLRSV 263
                                |.:|.|||   .:|:::|......|...........|....|:.:
Frog   287 AMDDGKSSLTSTNTTIGRNLSTHQGYSALSELSAFTIKQEASDSSSASSTPSSLCSPTFLDLQPI 351

  Fly   264 AAAAAAAHWPS-SH--SVSDILAHHQAVALRASCQVGVGVGGMGGMGSTVSPLP---------MT 316
            ::..:|..:.: ||  ||......|.|             .|...:|||:...|         ..
Frog   352 SSGCSAPSFSAFSHPASVYGQFTSHMA-------------SGRDVVGSTLPGYPPHIPSGQGNYA 403

  Fly   317 PSPVAG--TAGGQPLLDCEGGAGQQSPYNYY 345
            .|.:||  .|||    |..|.|.....|..|
Frog   404 SSAIAGMVAAGG----DYSGNAYSHGAYAAY 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Poxm	NP_001036687.1	PAX	10..133	CDD:128645	88/123 (72%)
pax8	XP_012814730.1	PAX	26..151	CDD:128645	88/123 (72%)
pax8	XP_012814730.1	Pax2_C	355..465	CDD:372091	23/93 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910