Protein Alignment Poxm and PAX5

DIOPT Version :10

• Sequence 1: NP_001036687.1
• Gene: Poxm / 40990
• FlyBaseID: FBgn0003129
• Length: 370
• Species: Drosophila melanogaster
• Sequence 2: NP_057953.1
• Gene: PAX5 / 5079
• HGNCID: 8619
• Length: 391
• Species: Homo sapiens
• Alignment Length: 418
• Identity: 154/418 - (36%)
• Similarity: 191/418 - (45%)
• Gaps: 90/418 - (21%)

  Fly     1 MDPESQCPQ-------YGEVNQLGGVFVNGRPLPNATRMRIVELARLGIRPCDISRQLRVSHGCV 58
            ||.|...|.       :|.|||||||||||||||:..|.||||||..|:||||||||||||||||
Human     1 MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCV 65

  Fly    59 SKILARYHETGSILPGAIGGSKPRVTTPKVVNYIRELKQRDPGIFAWEIRDRLLSEGICDKTNVP 123
            ||||.||:|||||.||.||||||:|.|||||..|.|.|:::|.:||||||||||:|.:||...||
Human    66 SKILGRYYETGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVP 130

  Fly   124 SVSSISRILRNKLGSLGHQHTPG---TVMGSGS---------SSGGGSVSSNG--------GQNN 168
            |||||:||:|.|:....:|..|.   :::.:||         .|.|.|.|.:|        ...|
Human   131 SVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYSISGILGITSPSADTN 195

  Fly   169 GTSASNNINLSNLGNPGGGPHHPHHHHHHQSAAAAASAHHVHAHAHAHAHLYNSIY---QP---- 226
            .......|..|.:.|....|.........:..........|........| |:.|:   :|
Human   196 KRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQH-YSDIFTTTEPIKPE 259

  Fly   227 ----YSAAAAYS-----MKTPCGSPSPPQGAGGQGSVPHPHQL-----RSVAAAAAAAHWPSSHS 277
                |||.|:.:     ||....||:|   |....|||.|...     |.:|:.....:.|
Human   260 QTTEYSAMASLAGGLDDMKANLASPTP---ADIGSSVPGPQSYPIVTGRDLASTTLPGYPP---- 317

  Fly   278 VSDILAHHQAVALRASCQVGVGVGGMGGMGSTVSP--LPMTP-SPVAGTAGGQPLLDCEGGAGQQ 339
                   |...|               |.||..:|  ..|.| |..:|:....|         |.
Human   318 -------HVPPA---------------GQGSYSAPTLTGMVPGSEFSGSPYSHP---------QY 351

  Fly   340 SPYNYYMYFQNGGMHHHHHHGGMMAAGA 367
            |.||....|.|.|:....::....|.||
Human   352 SSYNDSWRFPNPGLLGSPYYYSAAARGA 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Poxm	NP_001036687.1	PAX	10..133	CDD:128645	91/122 (75%)
PAX5	NP_057953.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		5/19 (26%)
		PAX	16..140	CDD:128645	91/123 (74%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	19..75		45/55 (82%)
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	94..142		30/47 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	182..218		6/35 (17%)
		Pax2_C	279..390	CDD:463563	32/139 (23%)