Protein Alignment Poxm and Pax8

DIOPT Version :10

• Sequence 1: NP_001036687.1
• Gene: Poxm / 40990
• FlyBaseID: FBgn0003129
• Length: 370
• Species: Drosophila melanogaster
• Sequence 2: NP_035170.1
• Gene: Pax8 / 18510
• MGIID: 97492
• Length: 457
• Species: Mus musculus
• Alignment Length: 414
• Identity: 154/414 - (37%)
• Similarity: 194/414 - (46%)
• Gaps: 79/414 - (19%)

  Fly    10 YGEVNQLGGVFVNGRPLPNATRMRIVELARLGIRPCDISRQLRVSHGCVSKILARYHETGSILPG 74
            :|.:|||||.||||||||...|.|||:||..|:||||||||||||||||||||.||:|||||.||
Mouse    10 HGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPG 74

  Fly    75 AIGGSKPRVTTPKVVNYIRELKQRDPGIFAWEIRDRLLSEGICDKTNVPSVSSISRILRNKLG-- 137
            .||||||:|.|||||..|.:.|:::|.:||||||||||:||:||...|||||||:||:|.|:.
Mouse    75 VIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQP 139

  Fly   138 --------------SLGHQHTPGTVM----GSGSSSGGGSVSSNG-------GQNN----GTSAS 173
                          |.||...|.:.:    ...|.|.|.:.|.||       |.:|    ..|..
Mouse   140 FNLPMDSCVATKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQPGNDNKRKMDDSDQ 204

  Fly   174 NNINLS-NLGNPGGGP-----------HH------PHHHHHHQSAAAAASAHHVHAHAHAHAHLY 220
            ::..|| :..:...||           ||      |....|:..|.|:.|      |......||
Mouse   205 DSCRLSIDSQSSSSGPRKHLRTDTFSQHHLEALECPFERQHYPEAYASPS------HTKGEQGLY 263

  Fly   221 -----NSIYQPYSAAAAYSMKTPCGSPSPPQGAGGQGSVPH-PHQLR-SVAAAAAAAHWPSSHSV 278
                 ||.... ..|...|..||.|............:.|| |..:: .....::::..|||.|.
Mouse   264 PLPLLNSALDD-GKATLTSSNTPLGRNLSTHQTYPVVADPHSPFAIKQETPELSSSSSTPSSLSS 327

  Fly   279 SDILAHHQAVALRASCQVGVGVGGMGGMGSTVSPLPMTP--SPVAGTAGGQPLLDCEGGAGQQSP 341
            |..|...|             ||..|..|::|.|....|  :.|.|...||.||......|...|
Mouse   328 SAFLDLQQ-------------VGSGGPAGASVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLP 379

  Fly   342 -YNYYMYFQNGGMHHHHHHGGMMA 364
             |..::.....|.:......||:|
Mouse   380 GYPPHIPTSGQGSYASSAIAGMVA 403

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Poxm	NP_001036687.1	PAX	10..133	CDD:128645	88/122 (72%)
Pax8	NP_035170.1	PAX	9..133	CDD:128645	88/122 (72%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	12..68		42/55 (76%)
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	87..135		30/47 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	159..224		14/64 (22%)
		Pax2_C	344..456	CDD:463563	16/60 (27%)