Protein Alignment Poxm and Pax6

DIOPT Version :10

• Sequence 1: NP_001036687.1
• Gene: Poxm / 40990
• FlyBaseID: FBgn0003129
• Length: 370
• Species: Drosophila melanogaster
• Sequence 2: NP_038655.1
• Gene: Pax6 / 18508
• MGIID: 97490
• Length: 436
• Species: Mus musculus
• Alignment Length: 426
• Identity: 142/426 - (33%)
• Similarity: 182/426 - (42%)
• Gaps: 124/426 - (29%)

  Fly    13 VNQLGGVFVNGRPLPNATRMRIVELARLGIRPCDISRQLR--------------VSHGCVSKILA 63
            |||||||||||||||::||.:|||||..|.|||||||.|:              ||:|||||||.
Mouse     8 VNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQTHADAKVQVLDNENVSNGCVSKILG 72

  Fly    64 RYHETGSILPGAIGGSKPRVTTPKVVNYIRELKQRDPGIFAWEIRDRLLSEGICDKTNVPSVSSI 128
            ||:|||||.|.|||||||||.||:||:.|.:.|:..|.||||||||||||||:|...|:||||||
Mouse    73 RYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSI 137

  Fly   129 SRILRN---------------KL----GSLGHQHT-----PGTVM-------GSGSSSGGG---- 158
            :|:|||               ||    |..|...|     |||.:       |.....|||
Mouse   138 NRVLRNLASEKQQMGADGMYDKLRMLNGQTGSWGTRPGWYPGTSVPGQPTQDGCQQQEGGGENTN 202

  Fly   159 SVSSNGG---------------QNNGTSASNNINLSNLGNPGGGPHHPHHHHHHQSAA------- 201
            |:||||.               |.|.||.:.. .:..|.......|:|......:.||
Mouse   203 SISSNGEDSDEAQMRLQLKRKLQRNRTSFTQE-QIEALEKEFERTHYPDVFARERLAAKIDLPEA 266

  Fly   202 -------------------------AAASAHHVHAHAHAHAHLYNSIYQPYSAAAAYSMKTPCG- 240
                                     |:.:..|:...:.....:|..|.||.:..::::..:..|
Mouse   267 RIQVWFSNRRAKWRREEKLRNQRRQASNTPSHIPISSSFSTSVYQPIPQPTTPVSSFTSGSMLGR 331

  Fly   241 ---------SPSPPQGAGGQGS-----VPHPHQLRSVAAAAAAAHWPSSHSVSDILAHHQAVALR 291
                     |..||..:....:     .|.|.|..|.:.....:...:..|.......|.
Mouse   332 TDTALTNTYSALPPMPSFTMANNLPMQPPVPSQTSSYSCMLPTSPSVNGRSYDTYTPPHM----- 391

  Fly   292 ASCQVGVGVGGMGGMGST----VSPLPMTPSPVAGT 323
               |..:....||..|:|    :||....|..|.|:
Mouse   392 ---QTHMNSQPMGTSGTTSTGLISPGVSVPVQVPGS 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Poxm	NP_001036687.1	PAX	10..133	CDD:128645	87/133 (65%)
Pax6	NP_038655.1	PAX	4..142	CDD:128645	87/133 (65%)
		Homeodomain	226..281	CDD:459649	8/55 (15%)