Protein Alignment Poxm and Pax2

DIOPT Version :10

• Sequence 1: NP_001036687.1
• Gene: Poxm / 40990
• FlyBaseID: FBgn0003129
• Length: 370
• Species: Drosophila melanogaster
• Sequence 2: NP_001355672.1
• Gene: Pax2 / 18504
• MGIID: 97486
• Length: 432
• Species: Mus musculus
• Alignment Length: 418
• Identity: 145/418 - (34%)
• Similarity: 190/418 - (45%)
• Gaps: 120/418 - (28%)

  Fly     2 DPESQC-PQYGEVNQLGGVFVNGRPLPNATRMRIVELARLGIRPCDISRQLRVSHGCVSKILARY 65
            ||.|.. |.:|.|||||||||||||||:..|.||||||..|:||||||||||||||||||||.||
Mouse     8 DPFSAMHPGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRY 72

  Fly    66 HETGSILPGAIGGSKPRVTTPKVVNYIRELKQRDPGIFAWEIRDRLLSEGICDKTNVPSVSSISR 130
            :|||||.||.||||||:|.|||||:.|.|.|:::|.:||||||||||:|||||...|||||||:|
Mouse    73 YETGSIKPGVIGGSKPKVATPKVVDKIAEYKRQNPTMFAWEIRDRLLAEGICDNDTVPSVSSINR 137

  Fly   131 ILRNKLGSLGHQHTPGTVMGSGSSSGGGSVSSNGGQNNGTSASN------NINLSNLGNPGGGPH 189
            |:|.|:....|....|.  |:|.::.|.::..:......:||||      :|| ..||.|
Mouse   138 IIRTKVQQPFHPTPDGA--GTGVTAPGHTIVPSTASPPVSSASNDPVGSYSIN-GILGIP----- 194

  Fly   190 HPHHHHHHQSAAAAASAHHVHAHAHAHAHLYNSIYQPYSAAAAYSMKTPCGSPSPPQGAGG---- 250
                    :|.........|..:.                           .|:..:|.||
Mouse   195 --------RSNGEKRKREEVEVYT---------------------------DPAHIRGGGGLHLV 224

  Fly   251 -------QGSVPH--------------------PHQLRSVAAAAAAAHWPSSHSVSDILAHHQ-- 286
                   :||||:                    ..||.::........:|.....|:.:...|
Mouse   225 WTLRDVSEGSVPNGDSQSGVDSLRKHLRADTFTQQQLEALDRVFERPSYPDVFQASEHIKSEQGN 289

  Fly   287 ----------------AVALRASCQVGVGVGG------MGGMGSTVSPLPMTPS----------P 319
                            :::..|:.::|..|.|      :.|...|.:.||..|.          |
Mouse   290 EYSLPALTPGLDEVKSSLSASANPELGSNVSGTQTYPVVTGRDMTSTTLPGYPPHVPPTGQGSYP 354

  Fly   320 VAGTAGGQPLLDCEGGAGQQSPYNYYMY 347
            .:..||..|     |.....:||::..|
Mouse   355 TSTLAGMVP-----GSEFSGNPYSHPQY 377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Poxm	NP_001036687.1	PAX	10..133	CDD:128645	93/122 (76%)
Pax2	NP_001355672.1	PAX	16..140	CDD:128645	93/123 (76%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	19..75		45/55 (82%)
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	94..142		32/47 (68%)
		Pax2_C	305..>390	CDD:463563	17/78 (22%)