DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAG and Mag

DIOPT Version :9

Sequence 1:	NP_002352.1	Gene:	MAG / 4099	HGNCID:	6783	Length:	626	Species:	Homo sapiens
Sequence 2:	NP_058886.1	Gene:	Mag / 29409	RGDID:	3035	Length:	626	Species:	Rattus norvegicus

Alignment Length:	626	Identity:	597/626 - (95%)
Similarity:	617/626 - (98%)	Gaps:	0/626 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWYFNSPY 65
            |||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat     1 MIFLTTLPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWYFNSPY 65

Human    66 PKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYNQYTFS 130
            ||||||||||||||||||||||||||||||||||||||||.:|||||||||||||||||||||||
  Rat    66 PKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSTLSPELGGKYYFRGDLGGYNQYTFS 130

Human   131 EHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGT 195
            |||||||:|||||||||||||||||||||||||||||||||||||||||||||.|||||||||||
  Rat   131 EHSVLDIINTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPTVLGRLREDEGT 195

Human   196 WVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLL 260
            ||||||||||||||||||||||||:|||||||||||||:||||||||||||||||||||||||||
  Rat   196 WVQVSLLHFVPTREANGHRLGCQAAFPNTTLQFEGYASLDVKYPPVIVEMNSSVEAIEGSHVSLL 260

Human   261 CGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYA 325
            |||||||||||||||||.||||||||||.|:||||||||||:||||||||||||||||.||||||
  Rat   261 CGADSNPPPLLTWMRDGMVLREAVAESLYLDLEEVTPAEDGIYACLAENAYGQDNRTVELSVMYA 325

Human   326 PWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEY 390
            |||||||||:|||||||||||||||||||||||||||||||:||||||:||||||||:|||||||
  Rat   326 PWKPTVNGTVVAVEGETVSILCSTQSNPDPILTIFKEKQILATVIYESQLQLELPAVTPEDDGEY 390

Human   391 WCVAENQYGQRATAFNLSVEFAPVLLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNE 455
            |||||||||||||||||||||||::||||||||||||||||||||||||||||||||||||||||
  Rat   391 WCVAENQYGQRATAFNLSVEFAPIILLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNE 455

Human   456 SEREFVYSERSGLVLTSILTLRGQAQAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAV 520
            :||||||||||||:||||||||||||||||||||:|||||.:|||||||||||||||||||||||
  Rat   456 TEREFVYSERSGLLLTSILTLRGQAQAPPRVICTSRNLYGTQSLELPFQGAHRLMWAKIGPVGAV 520

Human   521 VAFAILIAIVCYITQTRRKKNVTESPSFSAGDNPPVLFSSDFRISGAPEKYESERRLGSERRLLG 585
            ||||||||||||||||||||||||||||||||||.||:|.:|||||||:|||||:||||||||||
  Rat   521 VAFAILIAIVCYITQTRRKKNVTESPSFSAGDNPHVLYSPEFRISGAPDKYESEKRLGSERRLLG 585

Human   586 LRGEPPELDLSYSHSDLGKRPTKDSYTLTEELAEYAEIRVK 626
            |||||||||||||||||||||||||||||||||||||||||
  Rat   586 LRGEPPELDLSYSHSDLGKRPTKDSYTLTEELAEYAEIRVK 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAG	NP_002352.1	Interaction with RTN4R and RTN4RL2. /evidence=ECO:0000250\|UniProtKB:P07722	20..325		293/304 (96%)
		Ig_Siglec_N	22..139	CDD:143189	114/116 (98%)
		Ganglioside GT1b binding. /evidence=ECO:0000250\|UniProtKB:P20917	65..67		1/1 (100%)
		Ganglioside GT1b binding. /evidence=ECO:0000250\|UniProtKB:P20917	124..128		3/3 (100%)
		Ig	141..223	CDD:325142	79/81 (98%)
		Ig_3	239..309	CDD:316449	65/69 (94%)
		IG_like	333..409	CDD:214653	71/75 (95%)
		Required for normal axon myelination in the central nervous system. /evidence=ECO:0000250\|UniProtKB:P20917	577..626		48/48 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	582..608		25/25 (100%)
Mag	NP_058886.1	Interaction with RTN4R and RTN4RL2. /evidence=ECO:0000269\|PubMed:19420245	20..325		293/304 (96%)
		IgV_CD33	22..138	CDD:409377	113/115 (98%)
		Ig strand B	38..42	CDD:409377	3/3 (100%)
		Ig strand C	56..60	CDD:409377	3/3 (100%)
		Ganglioside GT1b binding. /evidence=ECO:0000250\|UniProtKB:P20917	65..67		1/1 (100%)
		Ig strand E	100..104	CDD:409377	3/3 (100%)
		Ig strand F	114..119	CDD:409377	4/4 (100%)
		Ganglioside GT1b binding. /evidence=ECO:0000250\|UniProtKB:P20917	124..128		3/3 (100%)
		Ig strand G	128..133	CDD:409377	4/4 (100%)
		IgC2_CD33_d2_like	141..235	CDD:409579	91/93 (98%)
		Ig strand B	155..159	CDD:409579	3/3 (100%)
		Ig strand C	171..175	CDD:409579	3/3 (100%)
		Ig strand E	200..204	CDD:409579	3/3 (100%)
		Ig strand F	214..219	CDD:409579	4/4 (100%)
		Ig strand G	229..232	CDD:409579	2/2 (100%)
		Ig_3	239..309	CDD:404760	65/69 (94%)
		Ig strand A	239..242	CDD:409353	2/2 (100%)
		Ig strand A'	248..251	CDD:409353	2/2 (100%)
		Ig strand B	256..264	CDD:409353	7/7 (100%)
		Ig strand C	270..274	CDD:409353	3/3 (100%)
		Ig strand C'	277..280	CDD:409353	1/2 (50%)
		Ig strand E	289..293	CDD:409353	1/3 (33%)
		Ig strand F	301..309	CDD:409353	6/7 (86%)
		Ig strand G	312..322	CDD:409353	8/9 (89%)
		IG	333..409	CDD:214652	71/75 (95%)
		Required for normal axon myelination in the central nervous system. /evidence=ECO:0000250\|UniProtKB:P20917	577..626		48/48 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	581..608		26/26 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83683128
Domainoid	1	1.000	438	1.000	Domainoid score	I9400
eggNOG	1	0.900	-	-		E1_KOG4475
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1771
Inparanoid	1	1.050	1230	1.000	Inparanoid score	I3917
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG40522
OrthoDB	1	1.010	-	-		D110010at32523
OrthoFinder	1	1.000	-	-		FOG0012344
OrthoInspector	1	1.000	-	-		oto133322
orthoMCL	1	0.900	-	-		OOG6_120404
Panther	1	1.100	-	-	LDO	PTHR12035
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X10298
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.270