DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ato and TAL1

DIOPT Version :9

Sequence 1:	NP_731223.1	Gene:	ato / 40975	FlyBaseID:	FBgn0010433	Length:	312	Species:	Drosophila melanogaster
Sequence 2:	NP_001274276.1	Gene:	TAL1 / 6886	HGNCID:	11556	Length:	331	Species:	Homo sapiens

Alignment Length:	270	Identity:	74/270 - (27%)
Similarity:	109/270 - (40%)	Gaps:	57/270 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 EQASSDGWISSSPASHRSESPEYVDLNTMYNGGCNNMAQNQQYGMIMEQSVVSTAPAIPVASPPA 129
            |.|.||..:....|:..|.:|.::.|       .|.:|:.           .|.|.|   |.||.
Human     8 EAARSDPQLEGRDAAEASMAPPHLVL-------LNGVAKE-----------TSRAAA---AEPPV 51

  Fly   130 VEV--MGSSNVGTCKTIPASAGP-----KPKRSYT--KKNQPSTTATSTPTAAAESSASVNLYTE 185
            :|:  .|....|     ||..|.     |.:.:.|  .:::..||....|...|.:.|..::..|
Human    52 IELGARGGPGGG-----PAGGGGAARDLKGRDAATAEARHRVPTTELCRPPGPAPAPAPASVTAE 111

  Fly   186 ---EFQNFDFDNSALFDDSVEDDEDLM-----LFSGGEDFDGNDGSFDLADGENQDAAAGGSGKK 242
               :.:.......||...:......|.     |.|.|..|.|...:|.:....|:        .|
Human   112 LPGDGRMVQLSPPALAAPAAPGRALLYSLSQPLASLGSGFFGEPDAFPMFTTNNR--------VK 168

  Fly   243 RRGK----QIT--PVVKRKRRLAANARERRRMQNLNQAFDRLRQYLPCLGNDRQLSKHETLQMAQ 301
            ||..    :||  |..|..||:..|:|||.|.||:|.||..||:.:|....|::|||:|.|::|.
Human   169 RRPSPYEMEITDGPHTKVVRRIFTNSRERWRQQNVNGAFAELRKLIPTHPPDKKLSKNEILRLAM 233

  Fly   302 TYISALGDLL 311
            .||:.|..||
Human   234 KYINFLAKLL 243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ato	NP_731223.1	HLH	253..312	CDD:238036	28/59 (47%)
TAL1	NP_001274276.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27		6/18 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..86		14/64 (22%)
		HLH	193..243	CDD:197674	23/49 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..331
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910