DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ato and NEUROD6

DIOPT Version :9

Sequence 1:	NP_731223.1	Gene:	ato / 40975	FlyBaseID:	FBgn0010433	Length:	312	Species:	Drosophila melanogaster
Sequence 2:	NP_073565.2	Gene:	NEUROD6 / 63974	HGNCID:	13804	Length:	337	Species:	Homo sapiens

Alignment Length:	151	Identity:	48/151 - (31%)
Similarity:	73/151 - (48%)	Gaps:	35/151 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 FDNSALFDDS---------VEDDEDL---------MLFSG-------GEDFDGNDGSFDLADGEN 231
            ||.|.:..:|         .||.:.:         ::..|       ||:.:..:   :..|.|.
Human     6 FDESVVMPESQMCRKFSRECEDQKQIKKPESFSKQIVLRGKSIKRAPGEETEKEE---EEEDREE 67

  Fly   232 QDAAAGGSGKKR--RGKQITPVVKRK---RRLAANARERRRMQNLNQAFDRLRQYLPCLGNDRQL 291
            :|  ..|..::|  |.|:.|.:...:   ||..||||||.||..||.|.|.||:.:||....::|
Human    68 ED--ENGLPRRRGLRKKKTTKLRLERVKFRRQEANARERNRMHGLNDALDNLRKVVPCYSKTQKL 130

  Fly   292 SKHETLQMAQTYISALGDLLR 312
            ||.|||::|:.||.||.::||
Human   131 SKIETLRLAKNYIWALSEILR 151

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ato	NP_731223.1	HLH	253..312	CDD:238036	29/61 (48%)
NEUROD6	NP_073565.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..82		9/43 (21%)
		Nuclear localization signal. /evidence=ECO:0000255	80..86		2/5 (40%)
		bHLH_TS_NeuroD6_ATOH2	82..151	CDD:381565	31/68 (46%)
		Neuro_bHLH	153..272	CDD:403655
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145398
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2611
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.870