DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ato and NEUROG2

DIOPT Version :9

Sequence 1:	NP_731223.1	Gene:	ato / 40975	FlyBaseID:	FBgn0010433	Length:	312	Species:	Drosophila melanogaster
Sequence 2:	NP_076924.1	Gene:	NEUROG2 / 63973	HGNCID:	13805	Length:	272	Species:	Homo sapiens

Alignment Length:	160	Identity:	49/160 - (30%)
Similarity:	66/160 - (41%)	Gaps:	49/160 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   202 VEDDEDLMLFSGG-------------------EDFDGNDG------SFDLADGENQDAAAGGSG- 240
            ::::||:::..|.                   |:..|..|      ..:...|.....|||..|
Human    10 LKEEEDVLVLLGSASPALAALTPLSSSADEEEEEEPGASGGARRQRGAEAGQGARGGVAAGAEGC 74

  Fly   241 ------------KKR--------RGKQITPVV---KRKRRLAANARERRRMQNLNQAFDRLRQYL 282
                        |:|        ||.:....|   |:.|||.||.|||.||.|||.|.|.||:.|
Human    75 RPARLLGLVHDCKRRPSRARAVSRGAKTAETVQRIKKTRRLKANNRERNRMHNLNAALDALREVL 139

  Fly   283 PCLGNDRQLSKHETLQMAQTYISALGDLLR 312
            |....|.:|:|.|||:.|..||.||.:.||
Human   140 PTFPEDAKLTKIETLRFAHNYIWALTETLR 169

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ato	NP_731223.1	HLH	253..312	CDD:238036	31/58 (53%)
NEUROG2	NP_076924.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..69		4/38 (11%)
		bHLH_TS_NGN2_ATOH4	104..172	CDD:381560	34/66 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	197..264
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145401
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840