DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ato and NEUROD1

DIOPT Version :9

Sequence 1:	NP_731223.1	Gene:	ato / 40975	FlyBaseID:	FBgn0010433	Length:	312	Species:	Drosophila melanogaster
Sequence 2:	NP_002491.3	Gene:	NEUROD1 / 4760	HGNCID:	7762	Length:	356	Species:	Homo sapiens

Alignment Length:	143	Identity:	53/143 - (37%)
Similarity:	79/143 - (55%)	Gaps:	19/143 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 YTEE-FQNFDFDNSALFDDSVEDDEDLM------LFSGGEDFDGNDGSFDLADGENQDAAAGGSG 240
            :|:| ..:.|.::.|   |..|||.:.|      |.:|||:.|.::   ||.:.|.::.......
Human    22 WTDECLSSQDEEHEA---DKKEDDLETMNAEEDSLRNGGEEEDEDE---DLEEEEEEEEEDDDQK 80

  Fly   241 KKRRGKQITPVVKRK------RRLAANARERRRMQNLNQAFDRLRQYLPCLGNDRQLSKHETLQM 299
            .||||.:...:.|.:      ||:.||||||.||..||.|.|.||:.:||....::|||.|||::
Human    81 PKRRGPKKKKMTKARLERFKLRRMKANARERNRMHGLNAALDNLRKVVPCYSKTQKLSKIETLRL 145

  Fly   300 AQTYISALGDLLR 312
            |:.||.||.::||
Human   146 AKNYIWALSEILR 158

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ato	NP_731223.1	HLH	253..312	CDD:238036	30/64 (47%)
NEUROD1	NP_002491.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..94		21/77 (27%)
		bHLH_TS_NeuroD1	75..160	CDD:381562	36/84 (43%)
		Nuclear localization signal. /evidence=ECO:0000255	87..93		0/5 (0%)
		Neuro_bHLH	160..284	CDD:403655
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145419
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2611
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.870