DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ato and MYCN

DIOPT Version :9

Sequence 1:	NP_731223.1	Gene:	ato / 40975	FlyBaseID:	FBgn0010433	Length:	312	Species:	Drosophila melanogaster
Sequence 2:	NP_001280157.1	Gene:	MYCN / 4613	HGNCID:	7559	Length:	464	Species:	Homo sapiens

Alignment Length:	269	Identity:	51/269 - (18%)
Similarity:	81/269 - (30%)	Gaps:	109/269 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 EQSVVSTAPAIPVASPPAVEVMGSSNVGTCKTIPASAGPKPKRSYTKKNQPSTTATSTPTAAAES 176
            |.:.|..|||...|:.||  |...:.:......|..|.|:|....|........:||     .|.
Human   201 EPAPVPAAPASAPAAGPA--VASGAGIAAPAGAPGVAPPRPGGRQTSGGDHKALSTS-----GED 258

  Fly   177 SASVNLYTEEFQNFDFDNSALFDDSVEDDEDLMLFSGGEDFDGNDGSFDLADGENQDA------- 234
            :.|           |.|:.   ||..||:|:               ..|:...|.:.:
Human   259 TLS-----------DSDDE---DDEEEDEEE---------------EIDVVTVEKRRSSSNTKAV 294

  Fly   235 -----------AAGGSGKKRRGKQI----------------TPVVK------------------- 253
                       ||.|.|:.:..:.|                :|.|:
Human   295 TTFTITVRPKNAALGPGRAQSSELILKRCLPIHQQHNYAAPSPYVESEDAPPQKKIKSEASPRPL 359

  Fly   254 --------------------RKRRLAANARERRRMQNLNQAFDRLRQYLPCLGNDRQLSKHETLQ 298
                                .:||...|..||:|..:|..:|..||.::|.|..:.:.:|...|:
Human   360 KSVIPPKAKSLSPRNSDSEDSERRRNHNILERQRRNDLRSSFLTLRDHVPELVKNEKAAKVVILK 424

  Fly   299 MAQTYISAL 307
            .|..|:.:|
Human   425 KATEYVHSL 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ato	NP_731223.1	HLH	253..312	CDD:238036	17/94 (18%)
MYCN	NP_001280157.1	Myc_N	10..372	CDD:279405	34/206 (17%)
		Interaction with AURKA. /evidence=ECO:0000269\|PubMed:27837025	19..47
		Interaction with AURKA and FBXW7. /evidence=ECO:0000269\|PubMed:27837025	61..89
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	129..172
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	196..294		27/128 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	334..392		6/57 (11%)
		HLH	379..438	CDD:238036	17/55 (31%)
		Leucine-zipper	433..454		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910