DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ato and Ahr

DIOPT Version :9

Sequence 1:	NP_731223.1	Gene:	ato / 40975	FlyBaseID:	FBgn0010433	Length:	312	Species:	Drosophila melanogaster
Sequence 2:	NP_037281.3	Gene:	Ahr / 25690	RGDID:	2074	Length:	853	Species:	Rattus norvegicus

Alignment Length:	198	Identity:	39/198 - (19%)
Similarity:	68/198 - (34%)	Gaps:	56/198 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RYYYKTSEDLQGFKTAAAEPYFNPMAAYNPGVTHYQFNGNTLASSSNYLSANGFISFEQASSDGW 72
            |.:|.....|||  ||...||.:.:              :::..:.|:...|..:..|.  |.|.
  Rat   676 RKHYSLFSGLQG--TAQEFPYKSEV--------------DSMPYTQNFAPCNQSLLPEH--SKGT 722

  Fly    73 ISSSPAS--HRSESPEYVDLNTMYNGGCNNMAQNQQYGMIMEQSVVSTAPAIPVASPPAVEVMGS 135
            ....|..  .||..|...:|....:  |..:.:||::|:..:.::||          |.....|:
  Rat   723 QLDFPGRDFERSLHPNASNLEDFVS--CLQVPENQRHGINSQSAMVS----------PQAYYAGA 775

  Fly   136 SNVGTCKTIPASAGPKPKRSYTKKNQPSTTATSTPTAAAESSASV---NLYTEEFQNFDFDNSAL 197
            .::..|:     |||:                .||....:.|..:   ..:..:||:....|.|.
  Rat   776 MSMYQCQ-----AGPQ----------------HTPVDQMQYSPEIPGSQAFLSKFQSPSILNEAY 819

  Fly   198 FDD 200
            ..|
  Rat   820 SAD 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
ato	NP_731223.1	HLH	253..312	CDD:238036
Ahr	NP_037281.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38
		HLH	36..77	CDD:238036
		DNA-binding. /evidence=ECO:0000250\|UniProtKB:P35869	37..65
		PAS	111..>181	CDD:279347
		PAS	111..177	CDD:214512
		Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activity. /evidence=ECO:0000250\|UniProtKB:P30561	116..124
		Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activity. /evidence=ECO:0000250\|UniProtKB:P30561	264..266
		PAS	280..384	CDD:238075
		PAS_3	295..380	CDD:285623
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	429..451
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910