DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ato and Mycn

DIOPT Version :9

Sequence 1:	NP_731223.1	Gene:	ato / 40975	FlyBaseID:	FBgn0010433	Length:	312	Species:	Drosophila melanogaster
Sequence 2:	NP_032735.3	Gene:	Mycn / 18109	MGIID:	97357	Length:	462	Species:	Mus musculus

Alignment Length:	360	Identity:	74/360 - (20%)
Similarity:	115/360 - (31%)	Gaps:	126/360 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SEDLQ------GFKTAAAEPYFNPMAAYNPGVTHYQFNGNTLASSSNYLSANGFISFEQASSDGW 72
            :|.||      |..:|.:.|   .:.|.:||       |..|..||:            ||..|.
Mouse   132 NEKLQHGHGPPGVSSACSAP---GVGASSPG-------GRALGGSSS------------ASHTGA 174

  Fly    73 ISSSPASHRSESPEYVDLNTMYNGGCNNMAQNQQYGMIMEQSVVSTAPAIPVASPPAVEVMGSSN 137
            ...:..||  .:.|.||...::....|....             ::.||.|.::|.....:.|.:
Mouse   175 TLPTDLSH--PAAECVDPAVVFPFPVNKRES-------------ASVPAAPTSAPATSAAVTSVS 224

  Fly   138 VGTCKTI--PASAGPKPKRSYTKKNQPSTTATSTPTAAAESSASVNLYTEEFQNFDFDNSALFDD 200
            |.....:  ||.||.:|..|...|      |.||   :.|.:.|           |.|:.   ||
Mouse   225 VPATAPVAAPARAGGRPASSGEAK------ALST---SGEDTLS-----------DSDDE---DD 266

  Fly   201 SVEDDE---DLMLFSGGEDFDGNDGSFDLADGENQDAAAGGSGKKRRGKQI-------------- 248
            ..||:|   |::..........|..............:|.|.|:.:.|:.|
Mouse   267 EEEDEEEEIDVVTVEKRRSSSNNKAVTTFTITVRPKTSALGLGRAQPGELILKRCVPIHQQHNYA 331

  Fly   249 --TPVVK---------------------------------------RKRRLAANARERRRMQNLN 272
              :|.|:                                       .:||...|..||:|..:|.
Mouse   332 APSPYVESEDAPPQKKIKSEASPRPLKSVVPAKAKSLSPRNSDSEDSERRRNHNILERQRRNDLR 396

  Fly   273 QAFDRLRQYLPCLGNDRQLSKHETLQMAQTYISAL 307
            .:|..||.::|.|..:.:.:|...|:.|..|:.||
Mouse   397 SSFLTLRDHVPELVKNEKAAKVVILKKATEYVHAL 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ato	NP_731223.1	HLH	253..312	CDD:238036	18/94 (19%)
Mycn	NP_032735.3	Myc_N	10..370	CDD:279405	56/297 (19%)
		Interaction with AURKA. /evidence=ECO:0000250\|UniProtKB:P04198	19..47
		Interaction with AURKA and FBXW7. /evidence=ECO:0000250\|UniProtKB:P04198	61..90
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	134..177		15/64 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	232..289		20/79 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	332..390		6/57 (11%)
		HLH	377..436	CDD:238036	18/55 (33%)
		Leucine-zipper	431..452		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910