DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9630 and DDX18

DIOPT Version :9

Sequence 1:	NP_649777.1	Gene:	CG9630 / 40974	FlyBaseID:	FBgn0037561	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_006764.3	Gene:	DDX18 / 8886	HGNCID:	2741	Length:	670	Species:	Homo sapiens

Alignment Length:	506	Identity:	184/506 - (36%)
Similarity:	276/506 - (54%)	Gaps:	47/506 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LSDAVLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEILQRRHKETPW 78
            :::..|:.::..||..||.:|..:|..||..:|:.|.|.||||||||||:|.:|::.:..    :
Human   186 VNENTLKAIKEMGFTNMTEIQHKSIRPLLEGRDLLAAAKTGSGKTLAFLIPAVELIVKLR----F 246

  Fly    79 GPKE-IGALVISPTRELARQISEVLAQFLEHEDLEHLNQQ-LIVGGNSIEEDIATLRRETPCILV 141
            .|:. .|.|::|||||||.|...||.:.:.|    |::.. ||:||::...:...|..... |:|
Human   247 MPRNGTGVLILSPTRELAMQTFGVLKELMTH----HVHTYGLIMGGSNRSAEAQKLGNGIN-IIV 306

  Fly   142 CTPGRLEDLFQRKGDDLNLAAQVKSLEFLVLDEADRLLDLGFKTSVNNILGYLPRQRRTGLFSAT 206
            .|||||.|..|.     ......|:|:.||:|||||:||:||:..:..|:..||.:|:|.|||||
Human   307 ATPGRLLDHMQN-----TPGFMYKNLQCLVIDEADRILDVGFEEELKQIIKLLPTRRQTMLFSAT 366

  Fly   207 QTTEVTDLIRAGL-RNPVLVSVKEKASVNTPARLQNFYRIVEPELKFVALLEFLSSPATVIGKVM 270
            ||.:|.||.|..| :.|:.|.|.:..:..|...|:..|.:...|.:|:.|..||.....  .|:|
Human   367 QTRKVEDLARISLKKEPLYVGVDDDKANATVDGLEQGYVVCPSEKRFLLLFTFLKKNRK--KKLM 429

  Fly   271 VFFPTCACVEYWAEALPPL-LPKRTVLGIHGKMK-NKRANVVEKFRNTPQAVLLCTDVLARGLDV 333
            |||.:|..|:|..|.|..: ||   ||.||||.| |||.....:|.|.....||||||.|||||:
Human   430 VFFSSCMSVKYHYELLNYIDLP---VLAIHGKQKQNKRTTTFFQFCNADSGTLLCTDVAARGLDI 491

  Fly   334 PEIEWVVQWDPPSTASSFVHRVGRTARQGN-EGNALVFLLPSEDAYVHFLKINQKVELTKLLTEE 397
            ||::|:||:|||.....::||||||||..| .|:||:.|.|.|..::.:|| ..||.|::.
Human   492 PEVDWIVQYDPPDDPKEYIHRVGRTARGLNGRGHALLILRPEELGFLRYLK-QSKVPLSEF---- 551

  Fly   398 AEDADREKKKLPAVLDQLHRLQAADKGVYDKGMRAFVSHVRAYTKHECSAILRLKDLDLGKMATA 462
                |....|:..:..||.:|...:..::.....|:.|::|||..|....|..:.:|:|.::|.:
Human   552 ----DFSWSKISDIQSQLEKLIEKNYFLHKSAQEAYKSYIRAYDSHSLKQIFNVNNLNLPQVALS 612

  Fly   463 YGLLQLPRMPEL----------KNYQGGGY-VAPAFEVDLSKLTYKNAQKE 502
            :| .::|...:|          |...|||: .....:|:.||: :|:..|:
Human   613 FG-FKVPPFVDLNVNSNEGKQKKRGGGGGFGYQKTKKVEKSKI-FKHISKK 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9630	NP_649777.1	DEADc	6..226	CDD:238167	84/214 (39%)
		DEXDc	22..232	CDD:214692	85/212 (40%)
		HELICc	239..370	CDD:238034	62/133 (47%)
		DUF4217	411..470	CDD:290667	14/58 (24%)
DDX18	NP_006764.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..169
		DEADc	179..386	CDD:238167	84/213 (39%)
		Q motif	179..207		5/20 (25%)
		DEXDc	194..382	CDD:214692	82/201 (41%)
		DEAD box	333..336		2/2 (100%)
		HELICc	400..529	CDD:238034	62/133 (47%)
		DUF4217	561..619	CDD:290667	14/58 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920