DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9630 and ddx18

DIOPT Version :9

Sequence 1:	NP_649777.1	Gene:	CG9630 / 40974	FlyBaseID:	FBgn0037561	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_001016776.1	Gene:	ddx18 / 549530	XenbaseID:	XB-GENE-6085268	Length:	640	Species:	Xenopus tropicalis

Alignment Length:	532	Identity:	186/532 - (34%)
Similarity:	277/532 - (52%)	Gaps:	64/532 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 WSSLDKPPLSDAVLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEILQ 70
            :|||.: .:::..|:.|...||..||.:|..||..||..:||.|.|.||||||||||:|.:|::.
Frog   147 FSSLAE-SVNENTLRAVTEMGFTHMTEIQHKAIRPLLEGRDVLAAARTGSGKTLAFLIPAIELVY 210

  Fly    71 RRHKETPWGPKE-IGALVISPTRELARQISEVLAQFLEHEDLEHLNQ-QLIVGGNSIEEDIATLR 133
            :    ..:.|:. .|.|::|||||||.|...||.:.:.|    |::. .||:||::...:...|.
Frog   211 K----LKFMPRNGTGVLILSPTRELAMQTYGVLKELMAH----HVHTFGLIMGGSNRSAEAQKLA 267

  Fly   134 RETPCILVCTPGRLEDLFQRKGDDLNLAAQVKSLEFLVLDEADRLLDLGFKTSVNNILGYLPRQR 198
            .... |:|.|||||.|..|.     ......|:|:.||:|||||:|::||:..:..|:..||::|
Frog   268 NGVN-IVVATPGRLLDHMQN-----TPGFMYKNLQCLVIDEADRILEVGFEQEMKQIINLLPKRR 326

  Fly   199 RTGLFSATQTTEVTDLIRAGL-RNPVLVSVKEKASVNTPARLQNFYRIVEPELKFVALLEFLSSP 262
            :|.|||||||.:|.||.|..| :.|:.|.|.:.....|...|:..|.:...|.:|:.|..||...
Frog   327 QTMLFSATQTRKVEDLARISLKKEPLYVGVDDHKETATVDGLEQGYVVCPSEKRFLLLFTFLKKN 391

  Fly   263 ATVIGKVMVFFPTCACVEYWAEALPPL-LPKRTVLGIHGKMK-NKRANVVEKFRNTPQAVLLCTD 325
            ..  .|:||||.:|..|:|..|.|..: ||   |:.||||.| .||.....:|.|....:|||||
Frog   392 RK--KKMMVFFSSCMSVKYHYELLNYIDLP---VMAIHGKQKQTKRTTTFFQFCNAESGILLCTD 451

  Fly   326 VLARGLDVPEIEWVVQWDPPSTASSFVHRVGRTARQ-GNEGNALVFLLPSEDAYVHFLKINQKVE 389
            |.|||||:||::|:||:|||.....::||||||||. ...|:||:.|.|.|..::.:|| ..||.
Frog   452 VAARGLDIPEVDWIVQYDPPDDPKEYIHRVGRTARGIDGRGHALLILRPEELGFLRYLK-QAKVP 515

  Fly   390 LTKLLTEEAEDADREKKKLPAVLDQLHRLQAADKGVYDKGMRAFVSHVRAYTKHECSAILRLKDL 454
            |::.        :....|:..:..||.:|...:..::.....|:.:::|||..|....|..:..|
Frog   516 LSEF--------EFSWSKISDIQTQLEKLIEKNYYLHKSAQEAYKAYIRAYDSHSHKQIFDVNTL 572

  Fly   455 DLGKMATAYGLLQLPRMPELKNYQGGGYVAPAFEVDLSKLTYKNAQKEQVRQKKMETYEQTGSWP 519
            :|.|:|.::| .|:|...:|.....||                         |:::.....|.:.
Frog   573 NLPKVAISFG-FQVPPFVDLNVNSSGG-------------------------KRLQKRGGGGGFG 611

  Fly   520 GQK---QHKKRV 528
            .||   |||.::
Frog   612 YQKSNNQHKAKI 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9630	NP_649777.1	DEADc	6..226	CDD:238167	89/222 (40%)
		DEXDc	22..232	CDD:214692	87/212 (41%)
		HELICc	239..370	CDD:238034	59/133 (44%)
		DUF4217	411..470	CDD:290667	15/58 (26%)
ddx18	NP_001016776.1	SrmB	145..634	CDD:223587	186/532 (35%)
		DEADc	147..354	CDD:238167	89/221 (40%)
		HELICc	368..497	CDD:238034	59/133 (44%)
		DUF4217	529..587	CDD:290667	15/58 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010