DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9630 and DDX56

DIOPT Version :9

Sequence 1:	NP_649777.1	Gene:	CG9630 / 40974	FlyBaseID:	FBgn0037561	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_061955.1	Gene:	DDX56 / 54606	HGNCID:	18193	Length:	547	Species:	Homo sapiens

Alignment Length:	624	Identity:	165/624 - (26%)
Similarity:	248/624 - (39%)	Gaps:	179/624 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LSDAVLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEILQRRHKETPW 78
            |...:||.|...|:.:.|.:|..||||.|..||:.|.|.||||||.|:.:|||::|..|....|.
Human    14 LDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGPV 78

  Fly    79 GPKEIGALVISPTRELARQISEVLAQFLEHEDLEHLNQQLIVGGNSIEEDIATLR---RETPCIL 140
            ..:.:..||:.||:|||||...::.|.     ..:..:.:.|...|..||..:.|   .|.|.::
Human    79 VEQAVRGLVLVPTKELARQAQSMIQQL-----ATYCARDVRVANVSAAEDSVSQRAVLMEKPDVV 138

  Fly   141 VCTPGRLEDLFQRKGDDLNLAAQVKSLEFLVLDEADRLLDLGFKTSVNNILGYLPRQRRTGLFSA 205
            |.||.|:....|:  |.|.|.   .|||.||:||||.|...||:..:.::|.:|||..:..|.||
Human   139 VGTPSRILSHLQQ--DSLKLR---DSLELLVVDEADLLFSFGFEEELKSLLCHLPRIYQAFLMSA 198

  Fly   206 TQTTEVTDLIRAGLRNPVLVSVKEKASVNTPARLQNFYRIVEPELKFVALLEFLSSPATVIGKVM 270
            |...:|..|....|.|||.:.::| :.:..|.:||.|..:.|.|.....||..|...:.:.||.:
Human   199 TFNEDVQALKELILHNPVTLKLQE-SQLPGPDQLQQFQVVCETEEDKFLLLYALLKLSLIRGKSL 262

  Fly   271 VF------------------FPTCACVEYWAEALPPLLPKRTVLGIHGKMKNKRANVVEKFRNTP 317
            :|                  .|||        .|...||.|:           |.:::.:|....
Human   263 LFVNTLERSYRLRLFLEQFSIPTC--------VLNGELPLRS-----------RCHIISQFNQGF 308

  Fly   318 QAVLLCTDV---------------------------LARGLDVPEIEWVVQWDPPSTASSFVHRV 355
            ...::.||.                           :|||:|...:..|:.:|.|.|..:::||.
Human   309 YDCVIATDAEVLGAPVKGKRRGRGPKGDKASDPEAGVARGIDFHHVSAVLNFDLPPTPEAYIHRA 373

  Fly   356 GRTARQGNEGNALVFLLPSEDAYVHFLKINQKVELTKLLTEEAEDADREKKKLPAVLDQLHRLQA 420
            |||||..|.|..|.|:||:|.  .|..||.:      ||:.|        .:.|.:|....|::.
Human   374 GRTARANNPGIVLTFVLPTEQ--FHLGKIEE------LLSGE--------NRGPILLPYQFRMEE 422

  Fly   421 ADKGVYDKGMRAFVSHVRAYTKHECSAILRLKDLDLGKMATAYGLLQLPRMPELKNYQGGGYVAP 485
            .:      |.|           :.|...:|    .:.|.|     ::..|:.|:|
Human   423 IE------GFR-----------YRCRDAMR----SVTKQA-----IREARLKEIK---------- 451

  Fly   486 AFEVDLSKLTYKNAQKEQVRQKKMETY-----------------------EQTGSWPGQ------ 521
                           :|.:..:|::||                       ...|..|..
Human   452 ---------------EELLHSEKLKTYFEDNPRDLQLLRHDLPLHPAVVKPHLGHVPDYLVPPAL 501

  Fly   522 ----KQHKKRVESWDQTKKAKLDAKSKKELRKAKKQRKK 556
                :.||||.:.....:||| .|||:..||..|.:.||
Human   502 RGLVRPHKKRKKLSSSCRKAK-RAKSQNPLRSFKHKGKK 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9630	NP_649777.1	DEADc	6..226	CDD:238167	80/214 (37%)
		DEXDc	22..232	CDD:214692	78/212 (37%)
		HELICc	239..370	CDD:238034	40/175 (23%)
		DUF4217	411..470	CDD:290667	8/58 (14%)
DDX56	NP_061955.1	Q motif	7..35		6/20 (30%)
		SrmB	9..513	CDD:223587	154/595 (26%)
		DEADc_DDX56	14..220	CDD:350719	80/215 (37%)
		DEAD box	166..169		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	506..547		15/35 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920