DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9630 and Ddx56

DIOPT Version :9

Sequence 1:	NP_649777.1	Gene:	CG9630 / 40974	FlyBaseID:	FBgn0037561	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_080814.1	Gene:	Ddx56 / 52513	MGIID:	1277172	Length:	546	Species:	Mus musculus

Alignment Length:	645	Identity:	166/645 - (25%)
Similarity:	251/645 - (38%)	Gaps:	180/645 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LSDAVLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEILQRRHKETPW 78
            |...:||.|...|:.:.|.:|..||||.|..||:.|.|.||||||.|:.:|||:.|..:....|.
Mouse    14 LDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQSLLHKKATGPV 78

  Fly    79 GPKEIGALVISPTRELARQISEVLAQFLEHEDLEHLNQQLIVGGNSIEEDIATLR---RETPCIL 140
            ..:.:..||:.||:|||||...::.|.     ..:..:.:.|...|..||.|:.|   .|.|.::
Mouse    79 MEQAVRGLVLVPTKELARQAQAMIQQL-----AAYCARDVRVANVSAAEDSASQRAVLMEKPDVV 138

  Fly   141 VCTPGRLEDLFQRKGDDLNLAAQVKSLEFLVLDEADRLLDLGFKTSVNNILGYLPRQRRTGLFSA 205
            |.||.|:....|:     |......|||.||:||||.|...||:..:.::|.:|||..:..|.||
Mouse   139 VGTPSRVLSHLQQ-----NTLKLRDSLELLVVDEADLLFSFGFEDELKSLLCHLPRIYQAFLMSA 198

  Fly   206 TQTTEVTDLIRAGLRNPVLVSVKEKASVNTPARLQNFYRIVEPELKFVALLEFLSSPATVIGKVM 270
            |...:|..|....|.|||.:.::| :.:..|.:||.|..:.|.|.....||..|...:.:.||.:
Mouse   199 TFNEDVQTLKELVLHNPVTLKLQE-SQLPGPDQLQQFQVVCETEEDKFLLLYALLKLSLIRGKAL 262

  Fly   271 VF------------------FPTCACVEYWAEALPPLLPKRTVLGIHGKMKNKRANVVEKFRNTP 317
            :|                  .|:|        .|...||.|:           |.:::.:|....
Mouse   263 LFVNTLERGYRLRLFLEQFSIPSC--------VLNGELPLRS-----------RCHIISQFNQGL 308

  Fly   318 QAVLLCTDV---------------------------LARGLDVPEIEWVVQWDPPSTASSFVHRV 355
            ...::.||.                           :|||:|...:..|:.:|.|.||.::|||.
Mouse   309 YDCVIATDAEILGPQVKGKRRGRGSKGNKASDPESGVARGIDFHHVSAVLNFDLPPTAEAYVHRA 373

  Fly   356 GRTARQGNEGNALVFLLPSEDAYVHFLKINQKVELTKLLTEEAEDADREKKKLPAVLDQLHRLQA 420
            |||||..|.|..|.|:||:|..::      .|:|  .||:.|.|        .|.:|....:::.
Mouse   374 GRTARANNPGIVLTFVLPAEQPFL------GKIE--DLLSGEGE--------APILLPYQFQMEE 422

  Fly   421 ADKGVYDKGMRAFVSHVRAYTKHECSAILRLKDLDLGKMATAYGLLQLPRMPELKNYQGGGYVAP 485
            .:.                 .::.|...:|    .:.|.|     ::..|:.|:|
Mouse   423 IES-----------------FRYRCRDAMR----SVTKQA-----IREARLKEIK---------- 451

  Fly   486 AFEVDLSKLTYKNAQKEQVRQKKMETYEQTGSWPGQ-------------KQHKKRVESWDQTKKA 537
                           :|.:..:|::||.:......|             |.|...|.
Mouse   452 ---------------EELLHSEKLKTYFEDNPRDLQLLRHDLPLHPAVVKPHLGHVP-------- 493

  Fly   538 KLDAKSKKELRKAKKQRKKAAEAEASRSGKGKKRQQFSQEDLDELASDIRLFK-RLKKNK 596
              |......||.....|||..:...||..|..|.|           :.:|.|| |.||.|
Mouse   494 --DYLVPAALRGLVHPRKKRRKVPFSRKAKKVKAQ-----------NPLRDFKHRGKKPK 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9630	NP_649777.1	DEADc	6..226	CDD:238167	78/214 (36%)
		DEXDc	22..232	CDD:214692	76/212 (36%)
		HELICc	239..370	CDD:238034	41/175 (23%)
		DUF4217	411..470	CDD:290667	5/58 (9%)
Ddx56	NP_080814.1	Q motif	7..35		6/20 (30%)
		SrmB	9..544	CDD:223587	166/645 (26%)
		P-loop_NTPase	9..219	CDD:304359	78/214 (36%)
		DEAD box	166..169		2/2 (100%)
		HELICc	234..388	CDD:238034	39/172 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	324..344		0/19 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..546		15/44 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920