DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9630 and pit

DIOPT Version :9

Sequence 1:	NP_649777.1	Gene:	CG9630 / 40974	FlyBaseID:	FBgn0037561	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_001287459.1	Gene:	pit / 42595	FlyBaseID:	FBgn0266581	Length:	680	Species:	Drosophila melanogaster

Alignment Length:	549	Identity:	190/549 - (34%)
Similarity:	285/549 - (51%)	Gaps:	72/549 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KKWSSLDKPPLSDAVLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEI 68
            :.::|| |..:|:|.|:.::..||.:||.:|:.::..||..:|:...|.||||||||||:|.:|:
  Fly   185 RSFASL-KGAVSEATLRAIKEMGFTEMTEIQSKSLTPLLKGRDLVGAAQTGSGKTLAFLIPAVEL 248

  Fly    69 LQRRHKETPWGPKE-IGALVISPTRELARQISEVLAQFLEHEDLEHLNQQLIVGGNSIEEDIATL 132
            :.:..    :.|:. .|.::|||||||:.|...||.:.:.|   .|....|::||::.:.:...|
  Fly   249 INKLR----FMPRNGTGVIIISPTRELSMQTFGVLKELMAH---HHHTYGLVMGGSNRQVESEKL 306

  Fly   133 RRETPCILVCTPGRLEDLFQRKGDDLNLAAQVKSLEFLVLDEADRLLDLGFKTSVNNILGYLPRQ 197
            .:... |||.|||||.|..|...|.|     .|:|:.|::||.||:|::||:..:..|:..||::
  Fly   307 GKGIN-ILVATPGRLLDHLQNSPDFL-----YKNLQCLIIDEVDRILEIGFEEELKQIINLLPKR 365

  Fly   198 RRTGLFSATQTTEVTDLIRAGLRN-PVLVSVKEKASVNTPARLQNFYRIVEPELKFVALLEFLSS 261
            |:|.|||||||..:..|.:..|:: |:.|.|.:.....|...|:..|.:...|.:.:.|..||..
  Fly   366 RQTMLFSATQTARIEALSKLALKSEPIYVGVHDNQDTATVDGLEQGYIVCPSEKRLLVLFTFLKK 430

  Fly   262 PATVIGKVMVFFPTCACVEYWAEALPPL-LPKRTVLGIHGKMK-NKRANVVEKFRNTPQAVLLCT 324
            ...  .||||||.:|..|:|..|....: ||   |..||||.| .||.....:|.|....:||||
  Fly   431 NRK--KKVMVFFSSCMSVKYHHELFNYIDLP---VTSIHGKQKQTKRTTTFFQFCNAESGILLCT 490

  Fly   325 DVLARGLDVPEIEWVVQWDPPSTASSFVHRVGRTAR-QGNEGNALVFLLPSEDAYVHFLKINQKV 388
            ||.|||||:|:::|:||:|||.....::|||||||| .|..|:||:.:.|.|..::.:||. .||
  Fly   491 DVAARGLDIPQVDWIVQYDPPDDPREYIHRVGRTARGSGTSGHALLLMRPEELGFLRYLKA-AKV 554

  Fly   389 ELTKLLTEEAEDADREKKKLPAVLDQLHRLQAADKGVYDKGMRAFVSHVRAYTKHECSAILRLKD 453
            .|.:.        :...:|:..:..||.:|.|.:..:......||.|:||||..|:...|..:..
  Fly   555 PLNEF--------EFSWQKIADIQLQLEKLIAKNYFLNQSAKEAFKSYVRAYDSHQLKQIFNVNT 611

  Fly   454 LDLGKMATAYGLLQLP-----------RMPELKNYQGGGYVAPAFEVDLSKLTYKNAQKEQVRQK 507
            |||..:|.::|.|..|           ..|| |...|||:   .|                  .|
  Fly   612 LDLQAVAKSFGFLVPPVVDLKVGAAKRERPE-KRVGGGGF---GF------------------YK 654

  Fly   508 KMETYEQTGSWPGQKQHKKRVESWDQTKK 536
            ||    ..|| ..:::|.|:|.. ||.||
  Fly   655 KM----NEGS-ASKQRHFKQVNR-DQAKK 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9630	NP_649777.1	DEADc	6..226	CDD:238167	82/221 (37%)
		DEXDc	22..232	CDD:214692	78/211 (37%)
		HELICc	239..370	CDD:238034	58/133 (44%)
		DUF4217	411..470	CDD:290667	20/69 (29%)
pit	NP_001287459.1	SrmB	186..677	CDD:223587	188/546 (34%)
		DEADc	187..394	CDD:238167	82/220 (37%)
		HELICc	408..537	CDD:238034	58/133 (44%)
		DUF4217	569..627	CDD:290667	19/57 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451681
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24031
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950