DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9630 and CG6418

DIOPT Version :9

Sequence 1:	NP_649777.1	Gene:	CG9630 / 40974	FlyBaseID:	FBgn0037561	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_648413.1	Gene:	CG6418 / 39218	FlyBaseID:	FBgn0036104	Length:	791	Species:	Drosophila melanogaster

Alignment Length:	558	Identity:	154/558 - (27%)
Similarity:	245/558 - (43%)	Gaps:	65/558 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 DAVLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPML-EILQRRHKETPWG 79
            :.:::.|:...:.|.||:|..|:|..|:.:|:...|.||||||.||:.||| .::.::..:...|
  Fly   278 EQLIKAVRKAEYTQPTPIQAQAVPTALSGRDIIGIAKTGSGKTAAFIWPMLMHVMDQKQLKPGDG 342

  Fly    80 PKEIGALVISPTRELARQISEVLAQFLEHEDLEHLNQQLIVGGNSIEEDIATLRRETPCILVCTP 144
            |  || |:::|||||:.||.....:|   ..:.:||.....||.|..|....|.:... |:|.||
  Fly   343 P--IG-LILAPTRELSLQIYNEAKKF---GKVYNLNVVCCYGGGSKWEQSKALEQGAE-IIVATP 400

  Fly   145 GRLEDLFQRKGDDLNLAAQVKSLEFLVLDEADRLLDLGFKTSVNNILGYLPRQRRTGLFSATQTT 209
            ||:.|:.:.|      |..::.:.|||||||||:..:||:..|.:|..::...|:..:||||...
  Fly   401 GRMIDMVKMK------ATNLRRVTFLVLDEADRMFHMGFEPQVRSICNHVRPDRQCLMFSATFKK 459

  Fly   210 EVTDLIRAGLRNPVLVSVKEKASVNTPARLQNFYRIVEPELKF----VALLEFLSSPATVIGKVM 270
            .:..|.|..|.:||.:...:....|... .|:.|....|..|:    ..|::|||.     |.|:
  Fly   460 RIERLARDVLSDPVRIVQGDLNEANQDI-TQSVYVFPNPLQKWNWLLCHLVKFLSE-----GSVL 518

  Fly   271 VFFPTCACVEYWAEALPPLLPKRTVLGIHGKM-KNKRANVVEKFRNTPQAVLLCTDVLARGLDVP 334
            :|.......|..:..|  |:.:...|.:||.| :..|..|:.:|:.....:|:.|||.|||||:|
  Fly   519 IFVTKKVDAETVSNNL--LIKEYNCLLLHGDMDQADRNKVITQFKRKECDILVATDVAARGLDIP 581

  Fly   335 EIEWVVQWDPPSTASSFVHRVGRTARQGNEGNALVFLLPSEDAYVHFLKINQKVELTKLLTEEAE 399
            .|..||.:|......:..||:|||.|.|.:|||            :.|..::..|....|....|
  Fly   582 HIRNVVNYDTARDIETHTHRIGRTGRAGEKGNA------------YTLVTDKDKEFAGHLVRNLE 634

  Fly   400 DADREKKKLPAVLDQLHRLQAADKGVYDKGMRAFVSHVRAYTKHECSAILRLKDLDLGKMATAYG 464
            .||:      .|.|.|  ::.|.|..:.:..|......:..|........|.|....|...:|.|
  Fly   635 GADQ------LVPDDL--MELAMKSSWFRSSRFKQGKGKRPTNTHTGLGYREKGNGGGGYGSAGG 691

  Fly   465 LLQLPRM--------PELKNYQGGGYVAPAFE-VDLSKLTYKNAQKEQVRQKKMETYEQT----G 516
            ......:        |..|.:...|   ||.: ....:..:::....|.|.....|:|:|    |
  Fly   692 SESTASVSAHSPSDGPSSKAFSSSG---PATDRYTAMREAFRSQYNNQFRASSDRTWEKTLPESG 753

  Fly   517 SWPGQKQHKKRVESWDQTKKAKLDAKSKKELRKAKKQR 554
            .:........  .|......:..:..|.::.::|||.|
  Fly   754 VFAAPMAPPS--SSTQGASASSANNSSNQDAKRAKKSR 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9630	NP_649777.1	DEADc	6..226	CDD:238167	73/210 (35%)
		DEXDc	22..232	CDD:214692	73/210 (35%)
		HELICc	239..370	CDD:238034	45/135 (33%)
		DUF4217	411..470	CDD:290667	12/58 (21%)
CG6418	NP_648413.1	DEADc	271..475	CDD:238167	73/209 (35%)
		DEXDc	284..489	CDD:214692	74/218 (34%)
		Helicase_C	504..609	CDD:278689	37/111 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451671
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24031
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940