DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9630 and CG8611

DIOPT Version :9

Sequence 1:	NP_649777.1	Gene:	CG9630 / 40974	FlyBaseID:	FBgn0037561	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_788922.1	Gene:	CG8611 / 32725	FlyBaseID:	FBgn0027602	Length:	975	Species:	Drosophila melanogaster

Alignment Length:	697	Identity:	199/697 - (28%)
Similarity:	311/697 - (44%)	Gaps:	148/697 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KWSSLDKPPLSDAVLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEIL 69
            |.|:|...|  .||..:......:::|.||...||.:|..|||...:.||||||||:.:|::|:|
  Fly   328 KISTLGLHP--HAVKNLEDLLSIRELTSVQQKTIPEVLQGKDVLVRSQTGSGKTLAYALPLVELL 390

  Fly    70 QRRHKETPWGPKEIG--ALVISPTRELARQISEVLAQFLEHEDLEHLNQQLIVGGNSIEEDIATL 132
            |   |:.|...::.|  ||||.|||||..|..|::.:.:  :....:....::||.|.:.:.|.|
  Fly   391 Q---KQQPRIQRKDGVLALVIVPTRELVMQTYELIQKLV--KPYTWIVPGSLLGGESRKSEKARL 450

  Fly   133 RRETPCILVCTPGRLEDLFQRKGDDLNLAA-QVKSLEFLVLDEADRLLDLGFKTSVNNILGYLPR 196
            |:... ||:.|||||.|..      |:.|: ::..|:||:||||||||:||::..|..::..:.:
  Fly   451 RKGIN-ILIGTPGRLVDHL------LHTASFKLTKLQFLILDEADRLLELGYERDVKQLVEAIDK 508

  Fly   197 QR-----------RTGLFSATQTTEVTDLIRAGLRNPVLVSVKEKAS------------------ 232
            ||           :..|.|||.|::|..|....|:||:.:...::|:
  Fly   509 QRAECEDKELPQLQRMLLSATLTSQVQQLAGLTLKNPLYIDNSDEAASAALKSKDGYQKETIEAL 573

  Fly   233 -----------------VNTPARLQNFYRIVEPELKFVALLEFL-----SSPATVIGKVMVFFPT 275
                             ::.|..||..|.:|.|:|:.|||...|     :||...  |.:||..|
  Fly   574 LEVDDGLGEYQEDVTGVLSIPENLQLSYVVVPPKLRLVALSSLLAKEVDASPKQF--KAIVFMST 636

  Fly   276 CACVEYWAEALPPLLPKRTV-------------------------LGIHGKM-KNKRANVVEKFR 314
            ...|.:..:.|...|.:|.:                         ..:||.| :.:|..|...||
  Fly   637 TEMVNFHHDMLNEALTRRVLDEEDEQEKGDSDDDGDIPLLQGLRFFKLHGSMTQTERQGVFRGFR 701

  Fly   315 NTPQAVLLCTDVLARGLDVPEIEWVVQWDPPSTASSFVHRVGRTARQGNEGNALVFLLPSEDAYV 379
            :....|||.|||:.||:|||:|:.|||:.||.|.:.||||||||||.|.:|.|::||.|||..:|
  Fly   702 DCASCVLLATDVVGRGIDVPDIKLVVQYTPPQTTADFVHRVGRTARAGRKGRAVLFLTPSEAQFV 766

  Fly   380 HFL-----KINQKVELTKLLTEEAEDADREKKKLPAVLDQLHRLQAA---DKGVYDKGMRAFVSH 436
            ..|     :|.|......|.|...:| |..:....|..:..|:.|..   |:.::||..:||||.
  Fly   767 RHLEKKRIRIQQGDMYAYLQTLLPKD-DEARTVQEAASNLQHKFQTLLEDDRELHDKSCKAFVSW 830

  Fly   437 VRAYT--KHECSAILRLKDLDLGKMATAYGLLQLPRMPELKNYQGGGYVAPAFEVDLSKLTYKNA 499
            ::.|:  ..|...|..::...:|..|.::.|.:.|.....|      :.||......::|||...
  Fly   831 MKFYSTFPKELKPIFNVRIAHMGHFAKSFALKEAPSKFAAK------HAAPKAAPPTNRLTYTER 889

  Fly   500 QKEQVRQKKMETYEQTGSWPGQKQHKKRVESWDQTKKAKLDAKSKKELRKAKKQRKKAAEAEASR 564
            ..|:::              .||:.|:|..:....:..:|      :.|....|:..|...:...
  Fly   890 DPEKIQ--------------AQKRAKRRFTTTVSGEVRQL------QQRDVGAQKPGAPPPKGGF 934

  Fly   565 SGKGKKRQQFSQEDLDELASDIRLFKRLKKNK-ISEEDFDKAMGIEG 610
            .|.|..|..|              .|.|.|:: ::..:||..:..||
  Fly   935 IGGGVGRSSF--------------MKSLGKSRALNMSEFDSGLPPEG 967

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9630	NP_649777.1	DEADc	6..226	CDD:238167	82/233 (35%)
		DEXDc	22..232	CDD:214692	77/223 (35%)
		HELICc	239..370	CDD:238034	58/161 (36%)
		DUF4217	411..470	CDD:290667	15/63 (24%)
CG8611	NP_788922.1	DUF2413	203..>285	CDD:287302
		P-loop_NTPase	332..548	CDD:304359	81/229 (35%)
		DEXDc	348..554	CDD:214692	77/217 (35%)
		HELICc	601..757	CDD:238034	56/157 (36%)
		DUF4217	805..866	CDD:290667	15/60 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451616
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24031
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950