DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9630 and Ddx18

DIOPT Version :9

Sequence 1:	NP_649777.1	Gene:	CG9630 / 40974	FlyBaseID:	FBgn0037561	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_001006997.1	Gene:	Ddx18 / 308490	RGDID:	1549712	Length:	674	Species:	Rattus norvegicus

Alignment Length:	512	Identity:	186/512 - (36%)
Similarity:	282/512 - (55%)	Gaps:	47/512 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LSDAVLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEILQRRHKETPW 78
            :::..|:.::..||:.||.:|..:|..||..:|:.|.|.||||||||||:|::|::.:    ..:
  Rat   190 VNENTLKAIEEMGFKHMTEIQHKSIRPLLEGRDLLAAAKTGSGKTLAFLIPVIELIVK----LKF 250

  Fly    79 GPKE-IGALVISPTRELARQISEVLAQFLEHEDLEHLNQQ-LIVGGNSIEEDIATLRRETPCILV 141
            .|:. .|.|::|||||||.|...||.:.:.|    |::.. ||:||::...::..|..... |:|
  Rat   251 MPRNGTGVLILSPTRELAMQTFGVLKELMTH----HVHTYGLIMGGSNRSAEVQKLLNGIN-IVV 310

  Fly   142 CTPGRLEDLFQRKGDDLNLAAQVKSLEFLVLDEADRLLDLGFKTSVNNILGYLPRQRRTGLFSAT 206
            .|||||.|..|.     ......|:|:.||:|||||:||:||:..:..|:..||.:|:|.|||||
  Rat   311 ATPGRLLDHMQN-----TPGFMYKNLQCLVIDEADRILDVGFEEELKQIIKLLPARRQTMLFSAT 370

  Fly   207 QTTEVTDLIRAGL-RNPVLVSVKEKASVNTPARLQNFYRIVEPELKFVALLEFLSSPATVIGKVM 270
            ||.:|.||.|..| :.|:.|.|.:...|.|...|:..|.:...|.:|:.|..||.....  .|||
  Rat   371 QTRKVEDLARISLKKEPLYVGVDDDKEVATVDGLEQGYVVCPSEKRFLLLFTFLKKNRK--KKVM 433

  Fly   271 VFFPTCACVEYWAEALPPL-LPKRTVLGIHGKMK-NKRANVVEKFRNTPQAVLLCTDVLARGLDV 333
            |||.:|..|:|..|.|..: ||   ||.||||.| |||.....:|.|....:||||||.|||||:
  Rat   434 VFFSSCMSVKYHYELLNYIDLP---VLAIHGKQKQNKRTTTFFQFCNADSGILLCTDVAARGLDI 495

  Fly   334 PEIEWVVQWDPPSTASSFVHRVGRTARQGN-EGNALVFLLPSEDAYVHFLKINQKVELTKLLTEE 397
            ||::|:||:|||.....::||||||||..| .|:||:.|.|.|..::.:|| ..||.|.:.
  Rat   496 PEVDWIVQYDPPDDPKEYIHRVGRTARGLNGRGHALLILRPEELGFLRYLK-QSKVPLNQF---- 555

  Fly   398 AEDADREKKKLPAVLDQLHRLQAADKGVYDKGMRAFVSHVRAYTKHECSAILRLKDLDLGKMATA 462
                |....|:..:..||.:|...:..::.....|:.|::|||..|....|..:.:|:|.::|.:
  Rat   556 ----DFSWSKVSDIQSQLEKLIEKNYFLHKSAQEAYKSYIRAYDSHSLKQIFNVNNLNLPQVALS 616

  Fly   463 YGLLQLPRMPEL----------KNYQGGGY-VAPAFEVDLSKLTYKNAQKEQVRQKK 508
            :| .::|...:|          |...|||: .....:|:.||: :|:..|:...:::
  Rat   617 FG-FKVPPFVDLNVSSHDGKLKKRGGGGGFGYQKTKKVEKSKI-FKHISKKPADRRQ 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9630	NP_649777.1	DEADc	6..226	CDD:238167	84/214 (39%)
		DEXDc	22..232	CDD:214692	85/212 (40%)
		HELICc	239..370	CDD:238034	63/133 (47%)
		DUF4217	411..470	CDD:290667	14/58 (24%)
Ddx18	NP_001006997.1	DEADc	183..390	CDD:238167	84/213 (39%)
		DEXDc	198..386	CDD:214692	82/201 (41%)
		HELICc	404..533	CDD:238034	63/133 (47%)
		DUF4217	565..623	CDD:290667	14/58 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920