DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm2 and MCM3

DIOPT Version :9

Sequence 1:	NP_477121.1	Gene:	Mcm2 / 40973	FlyBaseID:	FBgn0014861	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	NP_010882.1	Gene:	MCM3 / 856680	SGDID:	S000000758	Length:	971	Species:	Saccharomyces cerevisiae

Alignment Length:	768	Identity:	245/768 - (31%)
Similarity:	361/768 - (47%)	Gaps:	167/768 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 SMLGPRTEIANRFQSFLRTFVDERGAYTYRDRIRRMCEQNMSS---------------------- 214
            ::.|.|   ..|||.||.||.      :|||.:|.:...|.::
Yeast    19 AVFGDR---VRRFQEFLDTFT------SYRDSVRSIQVYNSNNAANYNDDQDDADERDLLGDDDG 74

  Fly   215 ---------------------FVVSYTDLANKEHVL--------AYFLPEAPFQMLEIFDKVAKD 250
                                 .::|..||...:...        |||:|.|        :|...|
Yeast    75 DDLEKEKKAASSTSLNILPHRIIISLDDLREFDRSFWSGILVEPAYFIPPA--------EKALTD 131

  Fly   251 MVLSI----FPTYERVTTEIHVRIS---------ELPLIEELRTFRKLHLNQLVRTLGVVTATTG 302
            :..|:    .|....|::....::|         ..|     ||....|||:||...|:||.|:.
Yeast   132 LADSMDDVPHPNASAVSSRHPWKLSFKGSFGAHALSP-----RTLTAQHLNKLVSVEGIVTKTSL 191

  Fly   303 VLPQLSVIKYDCVKCG-YVLGPFVQSQNTEIKPGSCPECQSTGPFSINMEQTLYR-----NYQKI 361
            |.|:|....:...|.| :....:..:..|.......|....|.....|...|.|.     ::|:|
Yeast   192 VRPKLIRSVHYAAKTGRFHYRDYTDATTTLTTRIPTPAIYPTEDTEGNKLTTEYGYSTFIDHQRI 256

  Fly   362 TLQESPGRIPAGRIPRSKDVILLADLCDQCKPGDELEVTGIYTNNYDGSLNTDQGFPV--FATVI 424
            |:||.|...|||::|||.||||..||.|:.||||.:.|.|::.:...|.:|......:  |.|:|
Yeast   257 TVQEMPEMAPAGQLPRSIDVILDDDLVDKTKPGDRVNVVGVFKSLGAGGMNQSNSNTLIGFKTLI 321

  Fly   425 IANHVVVKDSKQ----VVQSLTDEDIATIQKLSKDPRIVERVVASMAPSIYGHDYIKRALALALF 485
            :.|.|....::.    ..|.|||.||..|.||||...|.:.:..|:||||||||:||:|:.|.|.
Yeast   322 LGNTVYPLHARSTGVAARQMLTDFDIRNINKLSKKKDIFDILSQSLAPSIYGHDHIKKAILLMLM 386

  Fly   486 GGESKNPGEKHKVRGDINLLICGDPGTAKSQFLKYTEKVAPRAVFTTGQGASAVGLTAYVRRNPV 550
            ||..||......:|||||:|:.|||.|||||.|::....|..|:.|||:|:|.|||||.|..:..
Yeast   387 GGVEKNLENGSHLRGDINILMVGDPSTAKSQLLRFVLNTASLAIATTGRGSSGVGLTAAVTTDRE 451

  Fly   551 SREWTLEAGALVLADQGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAA 615
            :.|..|||||:||||:||..|||||||.|.||.:|||.||||:::|:||||.|:|.|||:|||||
Yeast   452 TGERRLEAGAMVLADRGVVCIDEFDKMTDVDRVAIHEVMEQQTVTIAKAGIHTTLNARCSVIAAA 516

  Fly   616 NPIGGRYDPSMTFSENVNLSEPILSRFDVLCVVKDEFDPMQDQQLAKFVVHSHM----------- 669
            ||:.|:||.:....:|:.|.:.:|||||:|.||.|:.:.::|:.:::.|:.:|.
Yeast   517 NPVFGQYDVNRDPHQNIALPDSLLSRFDLLFVVTDDINEIRDRSISEHVLRTHRYLPPGYLEGEP 581

  Fly   670 ------------------------------------KHHPSEEEQPEL----------------E 682
                                                :.|..|:..|.|                |
Yeast   582 VRERLNLSLAVGEDADINPEEHSNSGAGVENEGEDDEDHVFEKFNPLLQAGAKLAKNKGNYNGTE 646

  Fly   683 EPQLKTVDEIPQDLLRQYIVYAKENIRPKLTNIDEDKIAKMYAQLRQESFATGSLPITVRHIESV 747
            .|:|.|:     ..||:|:.||||.:.|:||....:.|.|.|..||.:. .|...|||.|.:|::
Yeast   647 IPKLVTI-----PFLRKYVQYAKERVIPQLTQEAINVIVKNYTDLRNDD-NTKKSPITARTLETL 705

  Fly   748 IRMSEAHARMHLRENVMEADVSMAIRMMLESFIEAQKFSVMKKMRSTFQKYLS 800
            ||::.|||::.|.:.|.:.|..:|..::..:.:.....:.:.:..|.:::.||
Yeast   706 IRLATAHAKVRLSKTVNKVDAKVAANLLRFALLGEDIGNDIDEEESEYEEALS 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:372227
		MCM_N	184..270	CDD:379644	24/140 (17%)
		MCM	276..780	CDD:214631	213/578 (37%)
MCM3	NP_010882.1	MCM_N	25..>137	CDD:405270	23/125 (18%)
MCM3	NP_010882.1	MCM	166..738	CDD:214631	214/582 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810