DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm2 and MCM4

DIOPT Version :9

Sequence 1:	NP_477121.1	Gene:	Mcm2 / 40973	FlyBaseID:	FBgn0014861	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	NP_015344.1	Gene:	MCM4 / 856130	SGDID:	S000006223	Length:	933	Species:	Saccharomyces cerevisiae

Alignment Length:	914	Identity:	257/914 - (28%)
Similarity:	446/914 - (48%)	Gaps:	134/914 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DNPSSPP--PNTPSDAAERRDLRAAMTSPVGDFEPFENEDEILGDQTVRDEAEEEDGEELFGDNM 64
            ||.||.|  ||..|       :...::||...:....::.:|.|....::.::.|       .|:
Yeast    12 DNNSSSPVVPNPDS-------VPPQLSSPALFYSSSSSQGDIYGRNNSQNLSQGE-------GNI 62

  Fly    65 ENDYRPMPELDHYDPALLDDEDDFSEMSQGDRFAAESEMRRRDRAAGIHRDDRDLGFGQSDDEDD 129
            .......| |:....:...:.|.|....:..|..:.:....|.|.....|.||.|....|    .
Yeast    63 RAAIGSSP-LNFPSSSQRQNSDVFQSQGRQGRIRSSASASGRSRYHSDLRSDRALPTSSS----S 122

  Fly   130 VGPRAKRRAGEKAAVGEVEDTEMVESIENLEDTKGHSTKEWVSMLGPRTEIA------------- 181
            :|...:.|...:.......|......|.:.:...|.:|.:..|...|.:|.:
Yeast   123 LGRNGQNRVHMRRNDIHTSDLSSPRRIVDFDTRSGVNTLDTSSSSAPPSEASEPLRIIWGTNVSI 187

  Fly   182 ----NRFQSFLRTF-------VDERGAYT---------YRDRIRRMCEQNMSSF------VVSYT 220
                ..|::||.:|       :|||..:.         |..::..|.|...|:.      :::|.
Yeast   188 QECTTNFRNFLMSFKYKFRKILDEREEFINNTTDEELYYIKQLNEMRELGTSNLNLDARNLLAYK 252

  Fly   221 DLANKEHVLAYFLPEAPFQMLEIFDKVAKDMVLSIFP------TYERVTTEIH-VRISELPLIEE 278
            ...:..|.|..:    |.:::.|.|:..||.::|:..      ..:.:.|:.: ||...:...:.
Yeast   253 QTEDLYHQLLNY----PQEVISIMDQTIKDCMVSLIVDNNLDYDLDEIETKFYKVRPYNVGSCKG 313

  Fly   279 LRTFRKLHLNQLVRTLGVVTATTGVLPQLSVIKYDCVKCGYVLGPFVQSQNTEI-KPGSCP--EC 340
            :|......:::|:...|:|..:|.|:|.:.|..:.|..|.:.:.  |:.....| :|..|.  :|
Yeast   314 MRELNPNDIDKLINLKGLVLRSTPVIPDMKVAFFKCNVCDHTMA--VEIDRGVIQEPARCERIDC 376

  Fly   341 QSTGPFSINMEQTLYRNYQKITLQESPGRIPAGRIPRSKDVILLADLCDQCKPGDELEVTG---- 401
            ......|:...:..:.:.|.|.|||:|..:|.|:.|.|..:.:..:|.|.|:.||.:||||
Yeast   377 NEPNSMSLIHNRCSFADKQVIKLQETPDFVPDGQTPHSISLCVYDELVDSCRAGDRIEVTGTFRS 441

  Fly   402 --IYTNNYDGSLNTDQGFPVFATVIIANHVVVKDSKQV-----------------------VQSL 441
              |..|:....|.:     ::.|.:...||.....|::                       |:.:
Yeast   442 IPIRANSRQRVLKS-----LYKTYVDVVHVKKVSDKRLDVDTSTIEQELMQNKVDHNEVEEVRQI 501

  Fly   442 TDEDIATIQKLSKDPRIVERVVASMAPSIYGHDYIKRALALALFGGESKNPGEKHKVRGDINLLI 506
            ||:|:|.|::::....:...:..|:|||||..:.:|:.:.|.||||.:|...:..:.|||||:|:
Yeast   502 TDQDLAKIREVAAREDLYSLLARSIAPSIYELEDVKKGILLQLFGGTNKTFTKGGRYRGDINILL 566

  Fly   507 CGDPGTAKSQFLKYTEKVAPRAVFTTGQGASAVGLTAYVRRNPVSREWTLEAGALVLADQGVCLI 571
            ||||.|:|||.|:|..|:.||.|:|:|:|:||||||||:.|:..:::..||:|||||:|.|||.|
Yeast   567 CGDPSTSKSQILQYVHKITPRGVYTSGKGSSAVGLTAYITRDVDTKQLVLESGALVLSDGGVCCI 631

  Fly   572 DEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSMTFSENVNLSE 636
            ||||||:|..|:.:||.||||:|||:||||:|:|.||.:::|:|||||.||:|::..:||::|..
Yeast   632 DEFDKMSDSTRSVLHEVMEQQTISIAKAGIITTLNARSSILASANPIGSRYNPNLPVTENIDLPP 696

  Fly   637 PILSRFDVLCVVKDEFDPMQDQQLAKFVVHSHMKHHPSEEEQPELEEPQLKTVDEIPQDLLRQYI 701
            |:|||||::.:|.|:.|...|::|||.:.:.::      |::||    .:...|.:|.:.|..||
Yeast   697 PLLSRFDLVYLVLDKVDEKNDRELAKHLTNLYL------EDKPE----HISQDDVLPVEFLTMYI 751

  Fly   702 VYAKENIRPKLTNIDEDKIAKMYAQLRQESFATGS----LPITVRHIESVIRMSEAHARMHLREN 762
            .||||:|.|.:|...:.::.:.|..:|:....:.|    :..|.|.:||:||::||||:|.|:..
Yeast   752 SYAKEHIHPIITEAAKTELVRAYVGMRKMGDDSRSDEKRITATTRQLESMIRLAEAHAKMKLKNV 816

  Fly   763 VMEADVSMAIRMM---LESFIEAQK-----FSVMKKMRSTFQKYLSFQKDHSELLFFILRQLTLD 819
            |...||..|:|::   ::.:....|     .::::..:|..|:.|  |:|.|..:..:|:....|
Yeast   817 VELEDVQEAVRLIRSAIKDYATDPKTGKIDMNLVQTGKSVIQRKL--QEDLSREIMNVLKDQASD 879

  Fly   820 QLAY 823
            .:::
Yeast   880 SMSF 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:372227	18/106 (17%)
		MCM_N	184..270	CDD:379644	22/114 (19%)
		MCM	276..780	CDD:214631	190/542 (35%)
MCM4	NP_015344.1	MCM_N	194..306	CDD:405270	23/115 (20%)
MCM4	NP_015344.1	MCM	310..834	CDD:214631	190/540 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810