Protein Alignment Mcm2 and MCM6

DIOPT Version :10

• Sequence 1: NP_477121.1
• Gene: Mcm2 / 40973
• FlyBaseID: FBgn0014861
• Length: 887
• Species: Drosophila melanogaster
• Sequence 2: NP_011314.2
• Gene: MCM6 / 852673
• SGDID: S000003169
• Length: 1017
• Species: Saccharomyces cerevisiae
• Alignment Length: 1001
• Identity: 263/1001 - (26%)
• Similarity: 433/1001 - (43%)
• Gaps: 291/1001 - (29%)

  Fly   120 GFGQSDDED-DVGPR---------------------------AKRRAGEKAAVGEVEDTEMVES- 155
            |||.|...| .:|.|                           ::|...:.:|..::|..|...|
Yeast    28 GFGSSSGLDSQIGSRLHFPSSSQPHVSNSQTGPFVNDSTQFSSQRLQTDGSATNDMEGNEPARSF 92

  Fly   156 -------IENLEDTKGHSTKEWVSMLGPRTEIANRFQSFLRTF---------VDERGAYTYRDRI 204
                   ::.::|..|...:|             .|:.||..|         |::    .||.:|
Yeast    93 KSRALNHVKKVDDVTGEKVRE-------------AFEQFLEDFSVQSTDTGEVEK----VYRAQI 140

  Fly   205 RRMCEQNMSSFVVSYTDLANKEH-VLAYFLPEAPFQMLEIFDKVAKDMVLSIFPTYERVTTEIHV 268
            ..|...::::..:.|..|:.:|: .||..:.|..::.|....|..:.:|....|  |.:.|...:
Yeast   141 EFMKIYDLNTIYIDYQHLSMRENGALAMAISEQYYRFLPFLQKGLRRVVRKYAP--ELLNTSDSL 203

  Fly   269 RISE------------------------------------------------------------- 272
            :.||
Yeast   204 KRSEGDEGQADEDEQQDDDMNGSSLPRDSGSSAAPGNGTSAMATRSITTSTSPEQTERVFQISFF 268

  Fly   273 -LPLIEELRTFRKLHLNQLVRTLGVVTATTGVLPQLSVIKYDCVKCGYVLGPFVQS-QNTEIKPG 335
             ||.:..:|..|...:..|:...|.||.|:.|.|:|....:.|..|..::....|| :.||  |.
Yeast   269 NLPTVHRIRDIRSEKIGSLLSISGTVTRTSEVRPELYKASFTCDMCRAIVDNVEQSFKYTE--PT 331

  Fly   336 SC--PECQSTGPFSINMEQTLYRNYQKITLQESPGRIPAGRIPRSKDVILLADLCDQCKPGDELE 398
            .|  |.|::...:::|:.::.:.::||:.:||:...||.|.:||:.||||..|..::.||||..:
Yeast   332 FCPNPSCENRAFWTLNVTRSRFLDWQKVRIQENANEIPTGSMPRTLDVILRGDSVERAKPGDRCK 396

  Fly   399 VTGI------------------YTNNYDGSLNTDQGFP--------------VFATVIIANHVV- 430
            .||:                  .|.:..|...|.:|..              .:....:|.||:
Yeast   397 FTGVEIVVPDVTQLGLPGVKPSSTLDTRGISKTTEGLNSGVTGLRSLGVRDLTYKISFLACHVIS 461

  Fly   431 ------------------------------------VKDSKQVVQSLTDEDIATIQKLSKDPRIV 459
                                                .:|.:..:.||:.::|..::::.||..|.
Yeast   462 IGSNIGASSPDANSNNRETELQMAANLQANNVYQDNERDQEVFLNSLSSDEINELKEMVKDEHIY 526

  Fly   460 ERVVASMAPSIYGHDYIKRALALALFGGESKNPGEKHKVRGDINLLICGDPGTAKSQFLKYTEKV 524
            :::|.|:||:::||:.:|:.:.|.:.||..|:..|..|:|||||:.:.|||.|:|||||||....
Yeast   527 DKLVRSIAPAVFGHEAVKKGILLQMLGGVHKSTVEGIKLRGDINICVVGDPSTSKSQFLKYVVGF 591

  Fly   525 APRAVFTTGQGASAVGLTAYVRRNPVSREWTLEAGALVLADQGVCLIDEFDKMNDQDRTSIHEAM 589
            |||:|:|:|:.:||.||||.|.|:....::|:|||||:|||.|:|.|||||||:..|:.:|||||
Yeast   592 APRSVYTSGKASSAAGLTAAVVRDEEGGDYTIEAGALMLADNGICCIDEFDKMDISDQVAIHEAM 656

  Fly   590 EQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSMTFSENVNLSEPILSRFDVLCVVKDEFDP 654
            |||:|||:||||..:|.||.:::|||||:||||:..::...|:|::.||:||||:..|:.|:.:.
Yeast   657 EQQTISIAKAGIHATLNARTSILAAANPVGGRYNRKLSLRGNLNMTAPIMSRFDLFFVILDDCNE 721

  Fly   655 MQDQQLAKFVVHSHMKHHPSEEEQPELEEPQLKTVDEIPQDLLRQYIVYAKENIRPKLTNIDEDK 719
            ..|.:||..:|..|||       :.|..||....      :.||:||.||: ..:|.||......
Yeast   722 KIDTELASHIVDLHMK-------RDEAIEPPFSA------EQLRRYIKYAR-TFKPILTKEARSY 772

  Fly   720 IAKMYAQLRQ---ESFATGSLPITVRHIESVIRMSEAHARMH----------------LRENVME 765
            :.:.|.:||:   :.|:..|..||||.:||:||:|||.||.:                ||::::.
Yeast   773 LVEKYKELRKDDAQGFSRSSYRITVRQLESMIRLSEAIARANCVDEITPSFIAEAYDLLRQSIIR 837

  Fly   766 ADVSMAIRMMLESF--IEAQKF---------------------------------------SVMK 789
            .||...  .|.|.|  ||:|..                                       |..|
Yeast   838 VDVDDV--EMDEEFDNIESQSHAASGNNDDNDDGTGSGVITSEPPADIEEGQSEATARPGTSEKK 900

  Fly   790 KMRSTFQKYLSFQKDHSELLFFILRQLTLDQLAYIRCKDGPGATHVEIMERDLIERAKQLDIVNL 854
            |...|:.||:|       ::..|:|     ::|.:..:.....|.|:|::..|::  |:.|:.:|
Yeast   901 KTTVTYDKYVS-------MMNMIVR-----KIAEVDREGAEELTAVDIVDWYLLQ--KENDLGSL 951

  Fly   855 KPFYESDLFRTNGFSYDPKRRIILQI 880
            ..::|.............|.||:::|
Yeast   952 AEYWEERRLAFKVIKRLVKDRILMEI 977

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:403724	14/81 (17%)
		MCM_N	182..271	CDD:464206	21/98 (21%)
		MCM	276..780	CDD:214631	198/596 (33%)
MCM6	NP_011314.2	MCM_N	112..195	CDD:464206	20/101 (20%)
		MCM	272..836	CDD:214631	193/579 (33%)
		MCM6_C	900..1007	CDD:465688	21/92 (23%)