Protein Alignment Mcm2 and MCM7

DIOPT Version :10

• Sequence 1: NP_477121.1
• Gene: Mcm2 / 40973
• FlyBaseID: FBgn0014861
• Length: 887
• Species: Drosophila melanogaster
• Sequence 2: NP_009761.4
• Gene: MCM7 / 852501
• SGDID: S000000406
• Length: 845
• Species: Saccharomyces cerevisiae
• Alignment Length: 769
• Identity: 247/769 - (32%)
• Similarity: 392/769 - (50%)
• Gaps: 98/769 - (12%)

  Fly   123 QSDDEDDVGPRAKRRAGEK-----AAVGEVEDTEMVESIENLEDTKGHSTKEWV------SMLGP 176
            :::||:......::...||     |.:.:|.:.|:...|.:|:|...:..::::      .::..
Yeast    41 ENEDENLDAENIEQHLLEKGPKYMAMLQKVANRELNSVIIDLDDILQYQNEKFLQGTQADDLVSA 105

  Fly   177 RTEIANRFQSFLRTFVDER-----GAYTYRDRI-------RRMCEQNMSSFVVSYTDLANKEHVL 229
            ..:.||.|.......:|..     ....|:|.:       ||:..:.|.|   ..|:....|:::
Yeast   106 IQQNANHFTELFCRAIDNNMPLPTKEIDYKDDVLDVILNQRRLRNERMLS---DRTNEIRSENLM 167

  Fly   230 AYFLPEAPFQMLEIFDKVAKDMVLSIFP--------TYERVTTEIHVR------ISELPLIEELR 280
            ...: :.|..|.:...:|.:|.. .:||        .|.:..::...|      ||..||  .:|
Yeast   168 DTTM-DPPSSMNDALREVVEDET-ELFPPNLTRRYFLYFKPLSQNCARRYRKKAISSKPL--SVR 228

  Fly   281 TFRKLHLNQLVRTLGVVTATTGVLPQLSVIKYDCVKCGYVLGPFVQSQN----TEIKPGSCPECQ 341
            ..:...|.||:...|::|..:.|.|.:.||.|.|.:|||.:...|.|:.    :|.....|.:.|
Yeast   229 QIKGDFLGQLITVRGIITRVSDVKPAVEVIAYTCDQCGYEVFQEVNSRTFTPLSECTSEECSQNQ 293

  Fly   342 STGPFSINMEQTLYRNYQKITLQESPGRIPAGRIPRSKDVILLADLCDQCKPGDELEVTGIY-TN 405
            :.|...::...:.:..:|:..:||...::|.|.||||.::.:...|.....|||.::||||: ..
Yeast   294 TKGQLFMSTRASKFSAFQECKIQELSQQVPVGHIPRSLNIHVNGTLVRSLSPGDIVDVTGIFLPA 358

  Fly   406 NYDGSLNTDQGFPVFATVIIANHVVVKDSKQVVQSLTDEDIATIQKLSKDPRIVERVVASMAPSI 470
            .|.|......|. :..|.:.|..|.....|....|||.:....:.:|.....:..|:..|:||.|
Yeast   359 PYTGFKALKAGL-LTETYLEAQFVRQHKKKFASFSLTSDVEERVMELITSGDVYNRLAKSIAPEI 422

  Fly   471 YGHDYIKRALALALFGGESKNPGEKHKVRGDINLLICGDPGTAKSQFLKYTEKVAPRAVFTTGQG 535
            ||:..:|:||.|.|.||..|..|:..|:|||||:.:.||||.||||.||...|::||.|:|||:|
Yeast   423 YGNLDVKKALLLLLVGGVDKRVGDGMKIRGDINVCLMGDPGVAKSQLLKAICKISPRGVYTTGKG 487

  Fly   536 ASAVGLTAYVRRNPVSREWTLEAGALVLADQGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAG 600
            :|.|||||.|.::||:.|..||.|||||||.|:|.|||||||::.|||:|||.||||:|||||||
Yeast   488 SSGVGLTAAVMKDPVTDEMILEGGALVLADNGICCIDEFDKMDESDRTAIHEVMEQQTISISKAG 552

  Fly   601 IVTSLQARCTVIAAANPIGGRYDPSMTFSENVNLSEPILSRFDVLCVVKDEFDPMQDQQLAKFVV 665
            |.|:|.||.:::|||||:.|||:|.::..:|:||...:|||||:|.::.|......|::||:.|.
Yeast   553 INTTLNARTSILAAANPLYGRYNPRLSPLDNINLPAALLSRFDILFLMLDIPSRDDDEKLAEHVT 617

  Fly   666 HSHMKHHPSEEEQPELE----EPQLKTVDEIPQDLLRQYIVYAKENIRPKLTNIDEDKIAKMYAQ 726
            :.||     ..:||:|:    ||          ..:|:||.|||.. ||.::....|.:.:.|.:
Yeast   618 YVHM-----HNKQPDLDFTPVEP----------SKMREYIAYAKTK-RPVMSEAVNDYVVQAYIR 666

  Fly   727 LRQES-------FATGSLPITVRHIESVIRMSEAHARMHLRENVMEADVSMAIRMMLES----FI 780
            |||:|       |:.|.  .|.|.:..:||:|:|.|::.|.:.|...||..|:|::..|    :.
Yeast   667 LRQDSKREMDSKFSFGQ--ATPRTLLGIIRLSQALAKLRLADMVDIDDVEEALRLVRVSKESLYQ 729

  Fly   781 EAQK-----------FSVMKKM-RSTFQKYLSFQKDHSELLFFILRQLTLDQLA 822
            |..|           |:::||| :.|.:..||::.....:.   ||..|:.||:
Yeast   730 ETNKSKEDESPTTKIFTIIKKMLQETGKNTLSYENIVKTVR---LRGFTMLQLS 780

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:403724	10/47 (21%)
		MCM_N	182..271	CDD:464206	19/114 (17%)
		MCM	276..780	CDD:214631	199/523 (38%)
MCM7	NP_009761.4	MCM_N	59..138	CDD:464206	13/78 (17%)
		MCM	223..724	CDD:214631	200/521 (38%)