DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm2 and MCM7

DIOPT Version :9

Sequence 1:	NP_477121.1	Gene:	Mcm2 / 40973	FlyBaseID:	FBgn0014861	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	NP_009761.4	Gene:	MCM7 / 852501	SGDID:	S000000406	Length:	845	Species:	Saccharomyces cerevisiae

Alignment Length:	769	Identity:	247/769 - (32%)
Similarity:	392/769 - (50%)	Gaps:	98/769 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 QSDDEDDVGPRAKRRAGEK-----AAVGEVEDTEMVESIENLEDTKGHSTKEWV------SMLGP 176
            :::||:......::...||     |.:.:|.:.|:...|.:|:|...:..::::      .::..
Yeast    41 ENEDENLDAENIEQHLLEKGPKYMAMLQKVANRELNSVIIDLDDILQYQNEKFLQGTQADDLVSA 105

  Fly   177 RTEIANRFQSFLRTFVDER-----GAYTYRDRI-------RRMCEQNMSSFVVSYTDLANKEHVL 229
            ..:.||.|.......:|..     ....|:|.:       ||:..:.|.|   ..|:....|:::
Yeast   106 IQQNANHFTELFCRAIDNNMPLPTKEIDYKDDVLDVILNQRRLRNERMLS---DRTNEIRSENLM 167

  Fly   230 AYFLPEAPFQMLEIFDKVAKDMVLSIFP--------TYERVTTEIHVR------ISELPLIEELR 280
            ...: :.|..|.:...:|.:|.. .:||        .|.:..::...|      ||..||  .:|
Yeast   168 DTTM-DPPSSMNDALREVVEDET-ELFPPNLTRRYFLYFKPLSQNCARRYRKKAISSKPL--SVR 228

  Fly   281 TFRKLHLNQLVRTLGVVTATTGVLPQLSVIKYDCVKCGYVLGPFVQSQN----TEIKPGSCPECQ 341
            ..:...|.||:...|::|..:.|.|.:.||.|.|.:|||.:...|.|:.    :|.....|.:.|
Yeast   229 QIKGDFLGQLITVRGIITRVSDVKPAVEVIAYTCDQCGYEVFQEVNSRTFTPLSECTSEECSQNQ 293

  Fly   342 STGPFSINMEQTLYRNYQKITLQESPGRIPAGRIPRSKDVILLADLCDQCKPGDELEVTGIY-TN 405
            :.|...::...:.:..:|:..:||...::|.|.||||.::.:...|.....|||.::||||: ..
Yeast   294 TKGQLFMSTRASKFSAFQECKIQELSQQVPVGHIPRSLNIHVNGTLVRSLSPGDIVDVTGIFLPA 358

  Fly   406 NYDGSLNTDQGFPVFATVIIANHVVVKDSKQVVQSLTDEDIATIQKLSKDPRIVERVVASMAPSI 470
            .|.|......|. :..|.:.|..|.....|....|||.:....:.:|.....:..|:..|:||.|
Yeast   359 PYTGFKALKAGL-LTETYLEAQFVRQHKKKFASFSLTSDVEERVMELITSGDVYNRLAKSIAPEI 422

  Fly   471 YGHDYIKRALALALFGGESKNPGEKHKVRGDINLLICGDPGTAKSQFLKYTEKVAPRAVFTTGQG 535
            ||:..:|:||.|.|.||..|..|:..|:|||||:.:.||||.||||.||...|::||.|:|||:|
Yeast   423 YGNLDVKKALLLLLVGGVDKRVGDGMKIRGDINVCLMGDPGVAKSQLLKAICKISPRGVYTTGKG 487

  Fly   536 ASAVGLTAYVRRNPVSREWTLEAGALVLADQGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAG 600
            :|.|||||.|.::||:.|..||.|||||||.|:|.|||||||::.|||:|||.||||:|||||||
Yeast   488 SSGVGLTAAVMKDPVTDEMILEGGALVLADNGICCIDEFDKMDESDRTAIHEVMEQQTISISKAG 552

  Fly   601 IVTSLQARCTVIAAANPIGGRYDPSMTFSENVNLSEPILSRFDVLCVVKDEFDPMQDQQLAKFVV 665
            |.|:|.||.:::|||||:.|||:|.::..:|:||...:|||||:|.::.|......|::||:.|.
Yeast   553 INTTLNARTSILAAANPLYGRYNPRLSPLDNINLPAALLSRFDILFLMLDIPSRDDDEKLAEHVT 617

  Fly   666 HSHMKHHPSEEEQPELE----EPQLKTVDEIPQDLLRQYIVYAKENIRPKLTNIDEDKIAKMYAQ 726
            :.||     ..:||:|:    ||          ..:|:||.|||.. ||.::....|.:.:.|.:
Yeast   618 YVHM-----HNKQPDLDFTPVEP----------SKMREYIAYAKTK-RPVMSEAVNDYVVQAYIR 666

  Fly   727 LRQES-------FATGSLPITVRHIESVIRMSEAHARMHLRENVMEADVSMAIRMMLES----FI 780
            |||:|       |:.|.  .|.|.:..:||:|:|.|::.|.:.|...||..|:|::..|    :.
Yeast   667 LRQDSKREMDSKFSFGQ--ATPRTLLGIIRLSQALAKLRLADMVDIDDVEEALRLVRVSKESLYQ 729

  Fly   781 EAQK-----------FSVMKKM-RSTFQKYLSFQKDHSELLFFILRQLTLDQLA 822
            |..|           |:::||| :.|.:..||::.....:.   ||..|:.||:
Yeast   730 ETNKSKEDESPTTKIFTIIKKMLQETGKNTLSYENIVKTVR---LRGFTMLQLS 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:372227	10/47 (21%)
		MCM_N	184..270	CDD:379644	18/111 (16%)
		MCM	276..780	CDD:214631	199/523 (38%)
MCM7	NP_009761.4	MCM_N	52..>123	CDD:405270	11/70 (16%)
MCM7	NP_009761.4	MCM	223..724	CDD:214631	200/521 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810