DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm2 and MCM5

DIOPT Version :9

Sequence 1:	NP_477121.1	Gene:	Mcm2 / 40973	FlyBaseID:	FBgn0014861	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	NP_013376.1	Gene:	MCM5 / 850980	SGDID:	S000004264	Length:	775	Species:	Saccharomyces cerevisiae

Alignment Length:	755	Identity:	233/755 - (30%)
Similarity:	379/755 - (50%)	Gaps:	135/755 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 TEIANRFQSFLRTF-VDERGAYTYRDRIRRMCEQNMSSFVVSYTDLANKEHVLAYFLPEAPFQML 241
            |||...|::|:..| :|.:  :.|||::|.      :..|.:|:...|.||::.|        ..
Yeast    25 TEIIKSFKNFILEFRLDSQ--FIYRDQLRN------NILVKNYSLTVNMEHLIGY--------NE 73

  Fly   242 EIFDKVAKDMVLSIFPTYERVTTEIHVRISELP----------------------LIEELRTFRK 284
            :|:.|:: |....|.|.:|...|::..|||.|.                      |:..|.||:.
Yeast    74 DIYKKLS-DEPSDIIPLFETAITQVAKRISILSRAQSANNNDKDPENTSMDTDSLLLNSLPTFQL 137

  Fly   285 L----------------HLNQLVRTLGVVTATTGVLPQLSVIKYDCVKCGYVLGPFVQ-----SQ 328
            :                |::::||..|::.:|:.:..:.:.:...|..|.:.....:.     :.
Yeast   138 ILNSNANQIPLRDLDSEHVSKIVRLSGIIISTSVLSSRATYLSIMCRNCRHTTSITINNFNSITG 202

  Fly   329 NTEIKPGSC---PECQST------------------GPFSINMEQTLYRNYQKITLQESPGRIPA 372
            ||...|.||   .|.:|:                  .|:.|..|.:.:.:.|.:.|||.|..:|.
Yeast   203 NTVSLPRSCLSTIESESSMANESNIGDESTKKNCGPDPYIIIHESSKFIDQQFLKLQEIPELVPV 267

  Fly   373 GRIPRSKDVILLADLCDQCKPGDELEVTGIYT--NNYDGSLNTDQG-----------FPVFATVI 424
            |.:||:..:.....|.::..||..:.:.|||:  |:.:|:.:...|           .|....:.
Yeast   268 GEMPRNLTMTCDRYLTNKVIPGTRVTIVGIYSIYNSKNGAGSGRSGGGNGGSGVAIRTPYIKILG 332

  Fly   425 IANHVVVKDSKQVVQSLTDEDIATIQKLSKDPRIVERVVASMAPSIYGHDYIKRALALALFGGES 489
            |.:.|........|...|:|:.....:||::|::.|.:..|:||||:|::.||:|:...|.||..
Yeast   333 IQSDVETSSIWNSVTMFTEEEEEEFLQLSRNPKLYEILTNSIAPSIFGNEDIKKAIVCLLMGGSK 397

  Fly   490 KNPGEKHKVRGDINLLICGDPGTAKSQFLKYTEKVAPRAVFTTGQGASAVGLTAYVRRNPVSREW 554
            |...:..::|||||:|:.|||||||||.||:.|||:|.||:|:|:|:||.||||.|:|:|::||:
Yeast   398 KILPDGMRLRGDINVLLLGDPGTAKSQLLKFVEKVSPIAVYTSGKGSSAAGLTASVQRDPMTREF 462

  Fly   555 TLEAGALVLADQGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIG 619
            .||.||:||||.||..|||||||.|:||.:||||||||:|||:||||.|.|.:|.:|:||||||.
Yeast   463 YLEGGAMVLADGGVVCIDEFDKMRDEDRVAIHEAMEQQTISIAKAGITTVLNSRTSVLAAANPIY 527

  Fly   620 GRYDPSMTFSENVNLSEPILSRFDVLCVVKDEFDPMQDQQLAKFVVHSHMKHHPSEEEQPELEEP 684
            ||||...:..:|::....||||||::.:|||:.:..:|..:|..|::.|..:..:.:.|.|
Yeast   528 GRYDDLKSPGDNIDFQTTILSRFDMIFIVKDDHNEERDISIANHVINIHTGNANAMQNQQE---- 588

  Fly   685 QLKTVDEIPQDLLRQYIVYAKENIRPKLTNIDEDKIAKMYAQLRQ-------ESFATGSLPITVR 742
              :...||..:.:::||.|.:....|:|:....:|::..:..:|:       ||....|:|||:|
Yeast   589 --ENGSEISIEKMKRYITYCRLKCAPRLSPQAAEKLSSNFVTIRKQLLINELESTERSSIPITIR 651

  Fly   743 HIESVIRMSEAHARMHLRENVMEADVSMAIRMMLESFIEA--------------------QKFSV 787
            .:|::||::|:.|::.|.....|..|..|||:...|.::|                    ::|..
Yeast   652 QLEAIIRITESLAKLELSPIAQERHVDEAIRLFQASTMDAASQDPIGGLNQASGTSLSEIRRFEQ 716

  Fly   788 MKKMRSTFQKYLSFQKDHSELLFFI----LRQLTLDQLAY 823
            ..|.|.......|:|....|   |:    ..||.||:..|
Yeast   717 ELKRRLPIGWSTSYQTLRRE---FVDTHRFSQLALDKALY 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:372227
		MCM_N	184..270	CDD:379644	21/86 (24%)
		MCM	276..780	CDD:214631	191/565 (34%)
MCM5	NP_013376.1	MCM_N	29..>101	CDD:405270	21/88 (24%)
MCM5	NP_013376.1	MCM	144..689	CDD:214631	188/550 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810