DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mcm2 and MCM5

DIOPT Version :10

Sequence 1:NP_477121.1 Gene:Mcm2 / 40973 FlyBaseID:FBgn0014861 Length:887 Species:Drosophila melanogaster
Sequence 2:NP_013376.1 Gene:MCM5 / 850980 SGDID:S000004264 Length:775 Species:Saccharomyces cerevisiae


Alignment Length:755 Identity:233/755 - (30%)
Similarity:379/755 - (50%) Gaps:135/755 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   178 TEIANRFQSFLRTF-VDERGAYTYRDRIRRMCEQNMSSFVVSYTDLANKEHVLAYFLPEAPFQML 241
            |||...|::|:..| :|.:  :.|||::|.      :..|.:|:...|.||::.|        ..
Yeast    25 TEIIKSFKNFILEFRLDSQ--FIYRDQLRN------NILVKNYSLTVNMEHLIGY--------NE 73

  Fly   242 EIFDKVAKDMVLSIFPTYERVTTEIHVRISELP----------------------LIEELRTFRK 284
            :|:.|:: |....|.|.:|...|::..|||.|.                      |:..|.||:.
Yeast    74 DIYKKLS-DEPSDIIPLFETAITQVAKRISILSRAQSANNNDKDPENTSMDTDSLLLNSLPTFQL 137

  Fly   285 L----------------HLNQLVRTLGVVTATTGVLPQLSVIKYDCVKCGYVLGPFVQ-----SQ 328
            :                |::::||..|::.:|:.:..:.:.:...|..|.:.....:.     :.
Yeast   138 ILNSNANQIPLRDLDSEHVSKIVRLSGIIISTSVLSSRATYLSIMCRNCRHTTSITINNFNSITG 202

  Fly   329 NTEIKPGSC---PECQST------------------GPFSINMEQTLYRNYQKITLQESPGRIPA 372
            ||...|.||   .|.:|:                  .|:.|..|.:.:.:.|.:.|||.|..:|.
Yeast   203 NTVSLPRSCLSTIESESSMANESNIGDESTKKNCGPDPYIIIHESSKFIDQQFLKLQEIPELVPV 267

  Fly   373 GRIPRSKDVILLADLCDQCKPGDELEVTGIYT--NNYDGSLNTDQG-----------FPVFATVI 424
            |.:||:..:.....|.::..||..:.:.|||:  |:.:|:.:...|           .|....:.
Yeast   268 GEMPRNLTMTCDRYLTNKVIPGTRVTIVGIYSIYNSKNGAGSGRSGGGNGGSGVAIRTPYIKILG 332

  Fly   425 IANHVVVKDSKQVVQSLTDEDIATIQKLSKDPRIVERVVASMAPSIYGHDYIKRALALALFGGES 489
            |.:.|........|...|:|:.....:||::|::.|.:..|:||||:|::.||:|:...|.||..
Yeast   333 IQSDVETSSIWNSVTMFTEEEEEEFLQLSRNPKLYEILTNSIAPSIFGNEDIKKAIVCLLMGGSK 397

  Fly   490 KNPGEKHKVRGDINLLICGDPGTAKSQFLKYTEKVAPRAVFTTGQGASAVGLTAYVRRNPVSREW 554
            |...:..::|||||:|:.|||||||||.||:.|||:|.||:|:|:|:||.||||.|:|:|::||:
Yeast   398 KILPDGMRLRGDINVLLLGDPGTAKSQLLKFVEKVSPIAVYTSGKGSSAAGLTASVQRDPMTREF 462

  Fly   555 TLEAGALVLADQGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIG 619
            .||.||:||||.||..|||||||.|:||.:||||||||:|||:||||.|.|.:|.:|:||||||.
Yeast   463 YLEGGAMVLADGGVVCIDEFDKMRDEDRVAIHEAMEQQTISIAKAGITTVLNSRTSVLAAANPIY 527

  Fly   620 GRYDPSMTFSENVNLSEPILSRFDVLCVVKDEFDPMQDQQLAKFVVHSHMKHHPSEEEQPELEEP 684
            ||||...:..:|::....||||||::.:|||:.:..:|..:|..|::.|..:..:.:.|.|    
Yeast   528 GRYDDLKSPGDNIDFQTTILSRFDMIFIVKDDHNEERDISIANHVINIHTGNANAMQNQQE---- 588

  Fly   685 QLKTVDEIPQDLLRQYIVYAKENIRPKLTNIDEDKIAKMYAQLRQ-------ESFATGSLPITVR 742
              :...||..:.:::||.|.:....|:|:....:|::..:..:|:       ||....|:|||:|
Yeast   589 --ENGSEISIEKMKRYITYCRLKCAPRLSPQAAEKLSSNFVTIRKQLLINELESTERSSIPITIR 651

  Fly   743 HIESVIRMSEAHARMHLRENVMEADVSMAIRMMLESFIEA--------------------QKFSV 787
            .:|::||::|:.|::.|.....|..|..|||:...|.::|                    ::|..
Yeast   652 QLEAIIRITESLAKLELSPIAQERHVDEAIRLFQASTMDAASQDPIGGLNQASGTSLSEIRRFEQ 716

  Fly   788 MKKMRSTFQKYLSFQKDHSELLFFI----LRQLTLDQLAY 823
            ..|.|.......|:|....|   |:    ..||.||:..|
Yeast   717 ELKRRLPIGWSTSYQTLRRE---FVDTHRFSQLALDKALY 753

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mcm2NP_477121.1 MCM2_N 59..166 CDD:403724
MCM_N 182..271 CDD:464206 22/89 (25%)
MCM 276..780 CDD:214631 191/565 (34%)
MCM5NP_013376.1 MCM_N 29..102 CDD:464206 22/89 (25%)
MCM 144..689 CDD:214631 188/550 (34%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.