Protein Alignment Mcm2 and MCM8

DIOPT Version :9

• Sequence 1: NP_477121.1
• Gene: Mcm2 / 40973
• FlyBaseID: FBgn0014861
• Length: 887
• Species: Drosophila melanogaster
• Sequence 2: NP_001268450.1
• Gene: MCM8 / 84515
• HGNCID: 16147
• Length: 880
• Species: Homo sapiens
• Alignment Length: 864
• Identity: 239/864 - (27%)
• Similarity: 380/864 - (43%)
• Gaps: 205/864 - (23%)

  Fly   158 NLEDTKGHSTKEWVSMLGPRTEIANRFQSFLRTFVDERG-----AYTYRDR---IRRMCEQNMSS 214
            :|..|.|..|.|........|:.....||.|..|:..:|     :..|.|.   |.::  |....
Human    39 DLSKTTGKRTSEQTPQFLLSTKTPQSMQSTLDRFIPYKGWKLYFSEVYSDSSPLIEKI--QAFEK 101

  Fly   215 FVVSYTDLANKEHV------------------LAYFLPEAPFQMLEIFDKVAKDMVLSIFPT--- 258
            |...:.||.:|:.:                  :...:|:...::.:..:|....|.|:|...
Human   102 FFTRHIDLYDKDEIERKGSILVDFKELTEGGEVTNLIPDIATELRDAPEKTLACMGLAIHQVLTK 166

  Fly   259 -YERVTTE-------------------IHVRISELPLIEELRTFRKLHLNQLVRTLGVVTATTGV 303
             .||...|                   ||.|:.....:.:|:..|..:..:.:...|.|...:.:
Human   167 DLERHAAELQAQEGLSNDGETMVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNI 231

  Fly   304 LPQLSVIKYDCVKCGYVLGPFVQSQNTEIKPGSC--PECQS-------TGPFSINMEQTLYRNYQ 359
            .|..:.:.:.|..||.:.. |.........|..|  |.|:.       :.|.::.|:      :|
Human   232 KPLCTKMAFLCAACGEIQS-FPLPDGKYSLPTKCPVPVCRGRSFTALRSSPLTVTMD------WQ 289

  Fly   360 KITLQE--SPGRIPAGRIPRSKDVILLADLCDQCKPGDELEVTGI--YTNNYDGSLNTDQGFPVF 420
            .|.:||  |..:..||||||:.:..|:.||.|.|.|||.:.:|||  .:|..:||.|.:... :|
Human   290 SIKIQELMSDDQREAGRIPRTIECELVHDLVDSCVPGDTVTITGIVKVSNAEEGSRNKNDKC-MF 353

  Fly   421 ATVIIANHVVVKDSK-QVVQSLTD------------EDIATIQKLSKDPRIVERVV---ASMAP- 468
            ...|.||.  :.:|| |..:|..|            :|:..||::..:..:.:.:|   .:::|
Human   354 LLYIEANS--ISNSKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKLIVKWSLALSPR 416

  Fly   469 -----SIYGHD-------------------------------YIKRALALALFGGESKNPGEKHK 497
                 :|..|.                               .:|..||||||||..|...:|::
Human   417 LEYSGAISAHCNLHLPSSNSSPTSACRVAGTTGMRHQTQLLLLVKAGLALALFGGSQKYADDKNR 481

  Fly   498 --VRGDINLLICGDPGTAKSQFLKYTEKVAPRAVFTTGQGASAVGLTAYVRRNPVSREWTLEAGA 560
              :|||.::|:.||||..|||.|:....||||.|:..|...:..|||..:.::..|.::.|||||
Human   482 IPIRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGA 546

  Fly   561 LVLADQGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPS 625
            |||.|||:|.|||||||.:|.: ::.|||||||||::|||:|.||.||.::||||||:||.|:.:
Human   547 LVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKA 610

  Fly   626 MTFSENVNLSEPILSRFDVLCVVKDEFDPMQDQQLAKFVVH--------------SHMKHHPSEE 676
            .|.|||:.:...:|||||::.::.|..:...|..|::.|:.              :.|....|..
Human   611 KTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRTISSATVARMNSQDSNT 675

  Fly   677 EQPEL--EEP---QLK-----TVDEIPQDLLRQYIVYAKENIRPKLTNIDEDKIAKMYAQLRQES 731
            ...|:  |:|   :||     |:|.||..|||:||.||::.:.|:|:......:...|.:||::|
Human   676 SVLEVVSEKPLSERLKVVPGETIDPIPHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQS 740

  Fly   732 FATGSLPITVRHIESVIRMSEAHARMHLRENVMEADVSMAIRMMLESFIEAQKFSVM-------- 788
            ....|.|||.|.:||:||::||.||:.|||...:.|.        |..:|..|:|::
Human   741 QRLNSSPITTRQLESLIRLTEARARLELREEATKEDA--------EDIVEIMKYSMLGTYSDEFG 797

  Fly   789 ------------KKMRSTFQKYLSFQKDHSE------LLFFILRQL----------------TLD 819
                        ...|||.::::|...:.:|      ..|..|||:                :|:
Human   798 NLDFERSQHGSGMSNRSTAKRFISALNNVAERTYNNIFQFHQLRQIAKELNIQVADFENFIGSLN 862

  Fly   820 QLAYIRCKDGPGATHVEIM 838
            ...|: .|.||....::.|
Human   863 DQGYL-LKKGPKVYQLQTM 880

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:372227	3/7 (43%)
		MCM_N	184..270	CDD:379644	23/134 (17%)
		MCM	276..780	CDD:214631	191/595 (32%)
MCM8	NP_001268450.1	MCM_N	98..223	CDD:291233	17/124 (14%)
		Mcm2	139..877	CDD:224162	219/757 (29%)
		AAA	475..633	CDD:99707	78/158 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820