Protein Alignment Mcm2 and MCM8

DIOPT Version :10

• Sequence 1: NP_477121.1
• Gene: Mcm2 / 40973
• FlyBaseID: FBgn0014861
• Length: 887
• Species: Drosophila melanogaster
• Sequence 2: NP_001319512.1
• Gene: MCM8 / 820123
• AraportID: AT3G09660
• Length: 801
• Species: Arabidopsis thaliana
• Alignment Length: 784
• Identity: 234/784 - (29%)
• Similarity: 376/784 - (47%)
• Gaps: 150/784 - (19%)

  Fly   139 GEKAAVGEVEDTEM------------VESIENL--EDTKGHSTKEWVSMLGPRTEIANRFQSFLR 189
            |...|.|..|.|.:            ::..|||  ::.|...|.|                 .:|
plant     6 GGSMASGRPESTGIDSLGIGKILAVYIKDNENLAIDEDKLQLTAE-----------------LIR 53

  Fly   190 TFVDERGAYTYRDRIRRMCEQNMSSFVVS--------YTDLANKEHVLAYF--LPEAPFQMLEIF 244
            .|....|    ||.:.::.|....||.:|        .:|:.|      :|  |.:.|..::...
plant    54 VFSASPG----RDIVSQVNEDGGGSFSLSLDLQQFKKISDIEN------FFINLEDNPKGVIPCM 108

  Fly   245 DKVAKDMVLSIFPT--YERVTTEIHVRISELPLIE-ELRTFRKLHLNQLVRTLGVVTATTGVLPQ 306
            :.....::...:.|  :|.| .:|:||:...|... .|:..|..::.:||...|.|...:.|.|.
plant   109 NAAVHKVLFDQWETNEFENV-MKINVRLHNYPESSISLKNLRAAYIGKLVTVHGTVVKVSTVKPL 172

  Fly   307 LSVIKYDCVKC--GYVLGPFVQSQNTEIKPGSCPECQSTG-------PFSINMEQTLYRNYQKIT 362
            ::.:.:||.||  |      :..:.|:.|.....:|.|.|       |.. :..||:  ::|||.
plant   173 VTQMAFDCGKCKTG------ITREFTDGKFSPPLKCDSHGCKSKTFTPIR-SSAQTI--DFQKIR 228

  Fly   363 LQE--SPGRIPAGRIPRSKDVILLADLCDQCKPGDELEVTGI--YTNNY----DGSLNT-DQGFP 418
            :||  .|.....||:||:.:..|:.||.|.|.|||.:.||||  ..|||    .|...| :|||
plant   229 VQELQKPEDHEEGRVPRTVECELMEDLVDICIPGDVVTVTGIIGVINNYMDIGGGKSKTKNQGF- 292

  Fly   419 VFATVIIANHVVVKDSKQV--------------------VQSLTDEDIATIQKLSKD--PRIVER 461
               ..:....|.||::|:.                    :.|.:..|:..|.|..::  .....|
plant   293 ---YYLFIEAVSVKNTKRQSAFENSEDSSSSAQTADVGDLYSFSQRDLEFIVKFKEEYGSDTFRR 354

  Fly   462 VVASMAPSIYGHDYIKRALALALFGGESKNPGEKHK--VRGDINLLICGDPGTAKSQFLKYTEKV 524
            ::.|:.||||||:.:|..:.|:||||..|:..:::|  |||||:::|.||||..|||.|:....:
plant   355 ILHSVCPSIYGHEIVKAGITLSLFGGVRKHSMDRNKVPVRGDIHVIIVGDPGLGKSQLLQAAAAI 419

  Fly   525 APRAVFTTGQGASAVGLTAYVRRNPVSREWTLEAGALVLADQGVCLIDEFDKMNDQDRTSIHEAM 589
            :||.::..|...:..|||..|.::.::.::..||||:||||.|:|.|||||||..:.: ::.|||
plant   420 SPRGIYVCGNATTRAGLTVAVVKDSMTNDYAFEAGAMVLADGGLCCIDEFDKMTTEHQ-ALLEAM 483

  Fly   590 EQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSMTFSENVNLSEPILSRFDVLCVVKDEFDP 654
            |||.:|::|||:|.||.||.:|||||||:||.|:.:.|.:||:.:|..:|||||::.::.|:.|.
plant   484 EQQCVSVAKAGLVASLSARTSVIAAANPVGGHYNRAKTVNENLKMSAALLSRFDLVFILLDKPDE 548

  Fly   655 MQDQQLAKFVVHSHMKHHPSEEEQPELEE------------------------PQLKTVDE---- 691
            :.|:|:::   |....|..|.|..|.|::                        .:|:...|
plant   549 LLDKQVSE---HIMSLHSASGETSPALKKFKPVNAASQNAGYANMHAEGNSLLSRLRLDSEKDDD 610

  Fly   692 ---IPQDLLRQYIVYAKENIRPKLTNIDEDKIAKMYAQLRQESFATGSLPITVRHIESVIRMSEA 753
               :|..|||:||.||:..:.||::....:.|.|.|.:||..:.:..|.|||.|.:||::|:::|
plant   611 FSPVPGQLLRKYISYARNFVNPKMSKDAGEIIQKFYLKLRDHNTSADSTPITARQLESLVRLAQA 675

  Fly   754 HARMHLRENVMEADVSMAIRMMLESFIE--AQKFSVMKKMRSTFQKYLSFQKDHSELLFFILRQL 816
            .||:.|||.:...|....:.:|.||..:  ..:..|:...||   ..:|.||:....|..:.:|.
plant   676 RARVDLREEITVQDAMDVVEIMKESLYDKLIDEHGVVDFGRS---GGMSQQKEAKRFLSALDKQS 737

  Fly   817 TLDQ 820
            .|.|
plant   738 ELQQ 741

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:403724	9/40 (23%)
		MCM_N	182..271	CDD:464206	20/100 (20%)
		MCM	276..780	CDD:214631	192/577 (33%)
MCM8	NP_001319512.1	Mcm2	80..788	CDD:440854	214/689 (31%)