DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm2 and MCM4

DIOPT Version :9

Sequence 1:	NP_477121.1	Gene:	Mcm2 / 40973	FlyBaseID:	FBgn0014861	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	NP_179236.3	Gene:	MCM4 / 816142	AraportID:	AT2G16440	Length:	847	Species:	Arabidopsis thaliana

Alignment Length:	817	Identity:	262/817 - (32%)
Similarity:	402/817 - (49%)	Gaps:	134/817 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DNPSSPPPNT-PSDAAERRDLRAAMTSPVGDFEPFENEDEILGDQTVRDEAEEEDGEELFGDNME 65
            :|.|||..|| .|.||..|..|...::|.....|
plant    19 ENVSSPIENTYSSPAALHRRRRGRSSTPTQFATP------------------------------- 52

  Fly    66 NDYRPMPELDHYDPALLDDEDDFSEMSQGDRFAAESEMRRRDRAAGIHRDDRDLGFGQSDDEDDV 130
                |.|      |:.|...:.....|:..  ||.|:.|......|......|.|...|.||
plant    53 ----PPP------PSRLASSNSTPPTSRPS--AARSKGRNGHGGGGGGGGGGDPGTPMSTDE--- 102

  Fly   131 GPRAKRRAGEKAAVGEVEDTEMVESIENLEDTKGHSTKEWVSMLGPRTEIANRFQSFLRTFVDER 195
             |......||:               :..:||.  .|..|.:.:..: ::.:..:.|::.|.:.|
plant   103 -PLPSSDDGEE---------------DGGDDTT--PTFVWGTNISVQ-DVKSAIEMFVKHFREAR 148

  Fly   196 ---------GAYTYRDRIRRMCE-----QNMSSF-VVSY-TDLANKEHVLAYFLPEAPFQMLEIF 244
                     |.|..  .||::.|     .::.:| |..| .||.||  ::.|     |.::|.||
plant   149 ENSDDLFREGKYMV--SIRKVIEIEGEWIDVDAFDVFDYDPDLYNK--MVRY-----PLEVLAIF 204

  Fly   245 DKVAKDMVLSIFPTYERVTTEIHVRISELPLIEELRTFRKLHLNQLVRTLGVVTATTGVLPQLSV 309
            |.|..|:|.:|...:|:   .:.|||..|.....:|......:.:::...|::..::.::|::..
plant   205 DIVLMDIVSTINRLFEK---HVQVRIFNLRTSTSMRNLNPSDIEKMISLKGMIIRSSSIIPEIRE 266

  Fly   310 IKYDCVKCGYVLGPFVQSQNTEIKPGSC--PECQSTGPFSINMEQTLYRNYQKITLQESPGRIPA 372
            ..:.|:.|||...|.:..:....:|.:|  .||.:....::...:..:.:.|.:.|||:|..||.
plant   267 AVFRCLVCGYFSDPIIVDRGKISEPPTCLKQECMTKNSMTLVHNRCRFADKQIVRLQETPDEIPE 331

  Fly   373 GRIPRSKDVILLADLCDQCKPGDELEVTGIY---TNNYDGSLNTDQGFPVFATVIIANHV----- 429
            |..|.:..::|...|.|..||||.:||||||   |.....:..|.:.  ||.|.|...|:
plant   332 GGTPHTVSLLLHDKLVDNGKPGDRIEVTGIYRAMTVRVGPAHRTVKS--VFKTYIDCLHIKKASK 394

  Fly   430 ---VVKDSKQVVQSL--TDEDI-------ATIQKLSKDPRIVERVVASMAPSIYGHDYIKRALAL 482
               ..:|...|..||  .|||:       ...|:|||.|.|.||:..|:||:|:..|.:|:.|..
plant   395 LRMSAEDPMDVDNSLRRVDEDVELDEEKLRKFQELSKQPDIYERLSRSLAPNIWELDDVKKGLLC 459

  Fly   483 ALFGGESKNPGEKHKVRGDINLLICGDPGTAKSQFLKYTEKVAPRAVFTTGQGASAVGLTAYVRR 547
            .||||.:.|.......|||||:|:.|||||:|||.|:|..|::||.::|:|:|:|||||||||.:
plant   460 QLFGGNALNLASGANFRGDINILLVGDPGTSKSQLLQYIHKLSPRGIYTSGRGSSAVGLTAYVAK 524

  Fly   548 NPVSREWTLEAGALVLADQGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVI 612
            :|.:.|..||:|||||:|:|:|.|||||||:|..|:.:||.||||::||:||||:.||.||.:|:
plant   525 DPETGETVLESGALVLSDRGICCIDEFDKMSDSARSMLHEVMEQQTVSIAKAGIIASLNARTSVL 589

  Fly   613 AAANPIGGRYDPSMTFSENVNLSEPILSRFDVLCVVKDEFDPMQDQQLAKFVVHSHMKHHPSEEE 677
            |.|||.|.||:|.::..||::|...:|||||::.::.|:.|...|::|||.:|..|.::..|.:|
plant   590 ACANPSGSRYNPRLSVIENIHLPPTLLSRFDLIYLILDKPDEQTDRRLAKHIVALHFENAESAQE 654

  Fly   678 QPELEEPQLKTVDEIPQDLLRQYIVYAKENIRPKLTNIDEDKIAKMYAQLRQESFATGS----LP 738
                        :.|....|..|:.||::||.|||::...:::.:.|.:||:.....||    :.
plant   655 ------------EAIDITTLTTYVSYARKNIHPKLSDEAAEELTRGYVELRKAGKFAGSSKKVIT 707

  Fly   739 ITVRHIESVIRMSEAHARMHLRENVMEADVSMAIRMM 775
            .|.|.|||:||:|||.|||...|.|.:.||..|.|::
plant   708 ATPRQIESLIRLSEALARMRFSEWVEKHDVDEAFRLL 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:372227	20/106 (19%)
		MCM_N	184..270	CDD:379644	27/101 (27%)
		MCM	276..780	CDD:214631	197/526 (37%)
MCM4	NP_179236.3	PHA03307	<2..>76	CDD:223039	20/99 (20%)
		MCM_N	140..231	CDD:405270	29/102 (28%)
		MCM	232..747	CDD:214631	197/527 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54431
OrthoDB	1	1.010	-	-		D266497at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.830