Protein Alignment Mcm2 and mcm6

DIOPT Version :9

• Sequence 1: NP_477121.1
• Gene: Mcm2 / 40973
• FlyBaseID: FBgn0014861
• Length: 887
• Species: Drosophila melanogaster
• Sequence 2: NP_001076318.1
• Gene: mcm6 / 566409
• ZFINID: ZDB-GENE-030909-6
• Length: 830
• Species: Danio rerio
• Alignment Length: 855
• Identity: 242/855 - (28%)
• Similarity: 394/855 - (46%)
• Gaps: 169/855 - (19%)

  Fly   139 GEKAAVGEVEDTEMVESIENLEDTKGHSTKEWVSMLGPRTEIANRFQSFLRTFVDERGAYTYRDR 203
            |.....|:|...|:.|..:.|                        ||:||..|.:..|...|...
Zfish     7 GVNQNAGQVIKDELAEKCQKL------------------------FQAFLEEFQNSDGEVKYLRD 47

  Fly   204 IRRMCEQNMSSFVVSYTDLANKEHVLAYFLPEAPFQMLEIFDKVAKDMVL--SIFPTYERVTTEI 266
            ...:.....::..||:|||......||..:.|..:::.....:..::...  ...||    :.|.
Zfish    48 AEELIRPERNTLAVSFTDLEGFNQELATAIQEEFYRLYPYLCRAVRNFAREHGEVPT----SKEF 108

  Fly   267 HVRISELPLIEELRTFRKLHLNQLVRTLGVVTATTGVLPQLSVIKYDCVKCGYVLGPFVQSQNTE 331
            :|...:||...::|....:.:..|||..|.|..|..|.|:|....:.|:.|..|:.. |:.|...
Zfish   109 YVAFQDLPTRHKIRELTTVKVGSLVRISGQVVRTHPVHPELVSGTFLCLDCQGVIKD-VEQQFKY 172

  Fly   332 IKPGSC--PECQSTGPFSINMEQTLYRNYQKITLQESPGRIPAGRIPRSKDVILLADLCDQCKPG 394
            .:|..|  |.|.:...|.::..::.:.::||:.:||:...:|.|.||||.:|||.|:..:..:.|
Zfish   173 TQPSICRNPVCNNRRRFLLDTNKSKFIDFQKLRIQETQAELPRGSIPRSMEVILRAEAVESAQAG 237

  Fly   395 D---------------ELEVTGIYTNNYDGSLNTDQGFP---------------VFATVIIANHV 429
            |               :|...|:.......:... ||:.               .:....:|.||
Zfish   238 DKCDFIGSLIVVPDISQLATPGVRAETSSRTAGV-QGYENEGLRGLKALGVRELSYKLAFLACHV 301

  Fly   430 V----------VKDSKQVVQS----LTDEDIATIQKLSKDPRIVERVVASMAPSIYGHDYIKRAL 480
            .          ::|.:|..:|    ::.::...:.::|:|..:...:..|:.|:|:|:|.:||.:
Zfish   302 APTNPRFGGKEIRDEEQTAESIKKQMSVQEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGI 366

  Fly   481 ALALFGGESKNPGEKHKVRGDINLLICGDPGTAKSQFLKYTEKVAPRAVFTTGQGASAVGLTAYV 545
            .|.||||..|...|...:|||||:.:.|||.||||||||:.|:..||||:|:|:.:||.||||.|
Zfish   367 LLMLFGGVPKTTMEGTSLRGDINVCVVGDPSTAKSQFLKHVEEFCPRAVYTSGKASSAAGLTAAV 431

  Fly   546 RRNPVSREWTLEAGALVLADQGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCT 610
            .|:..|.|:.:|||||:|||.|||.|||||||..:|:.:||||||||:|||:|||:..:|.||.:
Zfish   432 VRDEESHEFVIEAGALMLADNGVCCIDEFDKMETRDQVAIHEAMEQQTISITKAGVKATLNARTS 496

  Fly   611 VIAAANPIGGRYDPSMTFSENVNLSEPILSRFDVLCVVKDEFDPMQDQQLAKFVVHSHMKHHPSE 675
            ::|||||:.||||.|.:..:||||:.||:||||:..::.|:.:.:.|..:|:.:|..|.:...|.
Zfish   497 ILAAANPVSGRYDRSKSLKQNVNLTAPIMSRFDLFFILVDDCNEVTDYAIARRIVDLHSRIENSV 561

  Fly   676 EEQPELEEPQLKTVDEIPQDLLRQYIVYAKENIRPKLTNIDEDKIAKMYAQLRQE--SFATGSL- 737
            :....|:|             :|:|:::|:: .:||::...|:.|.:.|.:|||.  |..|.|.
Zfish   562 DRVYSLDE-------------IRRYLLFARQ-FKPKISKESEEFIVEQYKRLRQRDGSGVTKSAW 612

  Fly   738 PITVRHIESVIRMSEAHARMHLRENVMEADVSMAIRMMLESFIEAQKFSV--------------- 787
            .||||.:||:||:||:.||||..:.|....|..|.|::.:|.|..:...|
Zfish   613 RITVRQLESLIRLSESMARMHCCDEVQPKHVKEAFRLLNKSIIRVETPDVNLDQEEEEAMEEEED 677

  Fly   788 ---------------------------------------MKKMRSTFQKYLSFQKDHSELLFFIL 813
                                                   ...:|.:|.:|    |..|.||...|
Zfish   678 NQMNGHDVPNGVNGAVNGEVNGHEHTNGINGHGVNGETAKPSLRLSFAEY----KRISNLLVLHL 738

  Fly   814 RQLTLDQLAYIRCKDGPGATHVEIMERDLIERAKQLD----IVNLKPFYESDLFRTNGFSYDPKR 874
            |:...|:       |.......|::...|.|...::|    :::.|...|..::|...:.|
Zfish   739 RRAEEDE-------DEAALKKSEVVNWYLKEIESEIDSEMELISKKTMIEKVIYRLVHYDY---- 792

  Fly   875 RIILQIVVDG 884
             |::::...|
Zfish   793 -ILIELKQSG 801

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:372227	6/26 (23%)
		MCM_N	184..270	CDD:379644	19/87 (22%)
		MCM	276..780	CDD:214631	192/552 (35%)
mcm6	NP_001076318.1	MCM_N	27..137	CDD:291233	26/137 (19%)
		MCM	117..655	CDD:214631	192/553 (35%)
		P-loop_NTPase	<445..532	CDD:304359	54/86 (63%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820