Protein Alignment Mcm2 and mcm9

DIOPT Version :10

• Sequence 1: NP_477121.1
• Gene: Mcm2 / 40973
• FlyBaseID: FBgn0014861
• Length: 887
• Species: Drosophila melanogaster
• Sequence 2: NP_001333089.1
• Gene: mcm9 / 555610
• ZFINID: ZDB-GENE-041014-310
• Length: 1135
• Species: Danio rerio
• Alignment Length: 650
• Identity: 215/650 - (33%)
• Similarity: 334/650 - (51%)
• Gaps: 98/650 - (15%)

  Fly   171 VSMLGPRTEIANRFQSFLRTFVDERGAYTYRDRIRRMCEQNMSSF----VVSYTDLANKEHVLAY 231
            ||::|          ....|:|.|.    ::..|:::.::|....    ||:...|......:..
Zfish    10 VSLIG----------LVFETYVMEH----HKSDIQQILQENTEDLHYPVVVNAMTLFEDNMEVGE 60

  Fly   232 FLPEAPFQMLEIFDKVAKDMVLSIFPTYE-------RVTTEIHVRISELPLIEELRTFRKLHLNQ 289
            .....|.::|.|||...:....:|..:..       |:...:|||||.||:..||   .:.|:.:
Zfish    61 CFNAFPSKVLPIFDNALQRAAQAISQSSSSSPQDTFRLKHNMHVRISGLPVCPEL---TRDHIPK 122

  Fly   290 LVRTLGVVTATTGVLPQLSVIK-------YDCVKCGYVLGPFVQSQ----NTEIKPGSCPECQST 343
             .|.:|...:.||.:.:.||.|       |.|.||.:|..  ||:.    .|...|.|||..:..
Zfish   123 -ARDVGHFLSVTGTVIRTSVTKVLEYERDYMCNKCRHVFS--VQASFEQFYTFTPPTSCPSEEGC 184

  Fly   344 GPFSI------NMEQTLYRNYQKITLQESPGRIPAGRIPRSKDVILLADLCDQCKPGDELEVTGI 402
            |.|..      :......::||:|.:||...::..|.||||..:||..||.|.||.||::.|.|:
Zfish   185 GSFKFTCLSGSDAPPAACKDYQEIKIQEQVQKLSVGSIPRSMLIILEDDLVDSCKSGDDITVYGV 249

  Fly   403 YTNNYDGSLNTDQGFPVF-------ATVIIANHVVVKDSKQVVQSLTDEDIATIQK--------L 452
            ....:.         |:|       ..|:.||::.| :::|...:|..||   |||        .
Zfish   250 VCQRWK---------PMFQDCRCDVEIVLKANYIEV-NNEQSTTALVLED---IQKEFEEFWDSH 301

  Fly   453 SKDPRIVER--VVASMAPSIYGHDYIKRALALALFGGESKNPGEKHKVRGDINLLICGDPGTAKS 515
            ..|| |..|  ::.|:.|.::|...:|.|:|:.|.||..:......||||:.:||:.|||||.||
Zfish   302 KHDP-IAGRNEILMSLCPQVFGMYVVKLAVAMVLAGGVQRIDASGTKVRGESHLLLVGDPGTGKS 365

  Fly   516 QFLKYTEKVAPRAVFTTGQGASAVGLTAYVRRNPVSREWTLEAGALVLADQGVCLIDEFDKMNDQ 580
            |||||..|:.||:|.|.|.|::..|||....::  |.||.||||||||:|.|:|.||||:.:.:.
Zfish   366 QFLKYAAKITPRSVLTAGIGSTNAGLTVAAVKD--SGEWHLEAGALVLSDGGLCCIDEFNSIKEH 428

  Fly   581 DRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSMTFSENVNLSEPILSRFDVL 645
            ||||||||||||:||::|||:|..|..|.|::||.|| .|:|||:::.|.||.|:.|:|||||::
Zfish   429 DRTSIHEAMEQQTISVAKAGMVCKLDTRTTILAATNP-KGQYDPNVSVSVNVALASPLLSRFDLV 492

  Fly   646 CVVKDEFDPMQDQQLAKFVVHSHMKHHPSEEEQPELEEPQLKTVDEIPQDLLRQYIVYAKENIRP 710
            .|:.|..:|..|:.::.|::.:  |..|||            ::.....:.:|.|....| .::|
Zfish   493 LVLLDTKNPDWDKIISSFILQN--KGAPSE------------SLCLWSMEKMRAYFCLIK-TLKP 542

  Fly   711 KLTNIDEDKIAKMYAQLRQESFATGSLPITVRHIESVIRMSEAHARMHLRENVMEADVSMAIRMM 775
            ::|. :.:.|...|.||:::|.:..:...|:|.:||:.|::|||||:..||.|...|..:.:.:|
Zfish   543 RITP-EANTILSRYYQLQRQSDSRNAARTTIRMLESLSRLAEAHARLMFRETVTVEDAVVVVSVM 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:403724
		MCM_N	182..271	CDD:464206	18/99 (18%)
		MCM	276..780	CDD:214631	189/533 (35%)
mcm9	NP_001333089.1	Mcm2	16..593	CDD:440854	208/619 (34%)
		MCM9	311..609	CDD:350666	127/314 (40%)