Protein Alignment Mcm2 and mcm6

DIOPT Version :9

• Sequence 1: NP_477121.1
• Gene: Mcm2 / 40973
• FlyBaseID: FBgn0014861
• Length: 887
• Species: Drosophila melanogaster
• Sequence 2: NP_001016221.1
• Gene: mcm6 / 548975
• XenbaseID: XB-GENE-5870537
• Length: 821
• Species: Xenopus tropicalis
• Alignment Length: 676
• Identity: 217/676 - (32%)
• Similarity: 353/676 - (52%)
• Gaps: 86/676 - (12%)

  Fly   161 DTKGHSTKEWVSMLGPRTEIANRFQSFLRTFVDE----RGAYTYRDRIRRMCEQNMSSFVVSYTD 221
            ||.|...|:         |::::.|.....|::|    .|:..|......:.....::.||::||
 Frog    13 DTAGQLFKD---------ELSDKCQKLFLEFLEECKGKDGSNLYVSAAEELVRPERNTLVVNFTD 68

  Fly   222 LANKEHVLAYFLPEAPFQMLEIFDKVAKDMV--LSIFPTYERVTTEIHVRISELPLIEELRTFRK 284
            :......||..:.|..:::.....:..:...  :...|    ...|.:|..|:.|..:::|....
 Frog    69 IEYYNQQLATTIQEEYYRVYPHLCRAVRSFARQMGNIP----ANKEFYVAFSDFPARQKIRELSS 129

  Fly   285 LHLNQLVRTLGVVTATTGVLPQLSVIKYDCVKCGYVLGPFVQSQNTEIKPGSC--PECQSTGPFS 347
            ..:..|:|..|.|..|..|.|:|....:.|:.|..|:.. |:.|....:|..|  |.|.:...|:
 Frog   130 AKIGTLLRISGQVVRTHPVHPELVSGTFLCMDCQSVVKD-VEQQFRYTQPTICKNPVCANRRRFT 193

  Fly   348 INMEQTLYRNYQKITLQESPGRIPAGRIPRSKDVILLADLCDQCKPGDELEVTGIYTNNYD---- 408
            ::..::.:.::||:.:||:...:|.|.||||.::||.|:..:....||..:.||......|
 Frog   194 LDTNKSRFVDFQKVRIQETQAELPRGAIPRSVEIILRAEAVETAMAGDRCDFTGTLIVVPDISAL 258

  Fly   409 --GSLNTDQGFPV-----------------------FATVIIANHV----------VVKDSKQVV 438
              |....:.|..|                       :....:|.||          .:::..|..
 Frog   259 AAGDARMETGAKVTGGEGFNSEGVQGLKALGVRDLSYRLAFLACHVGATNPRFGGKDLREEDQTA 323

  Fly   439 QSLTDEDIATIQ------KLSKDPRIVERVVASMAPSIYGHDYIKRALALALFGGESKNPGEKHK 497
            :|:.::  .|:|      ::|:|..:...:..|:.|:|:|:|.|||.:.|.||||..|...|...
 Frog   324 ESIKNQ--MTVQEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEIKRGVLLMLFGGVPKTTMEGTS 386

  Fly   498 VRGDINLLICGDPGTAKSQFLKYTEKVAPRAVFTTGQGASAVGLTAYVRRNPVSREWTLEAGALV 562
            :|||||:.|.|||.|:||||||:.|:.:||||:|:|:.:||.||||.|.::..|.|:.:|||||:
 Frog   387 LRGDINVCIVGDPSTSKSQFLKHVEEFSPRAVYTSGKASSAAGLTAAVVKDEESHEFVIEAGALM 451

  Fly   563 LADQGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSMT 627
            |||.|||.|||||||:.:|:.:||||||||:|||:|||:..:|.||.:::|||||:||||:.|.:
 Frog   452 LADNGVCCIDEFDKMDLKDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVGGRYERSKS 516

  Fly   628 FSENVNLSEPILSRFDVLCVVKDEFDPMQDQQLAKFVVHSHMKHHPSEEEQPELEEPQLKTVDEI 692
            ...|||||.||:||||:..::.||.:.:.|..:|:.:|..|.::..|.|....:|:
 Frog   517 LKHNVNLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHARNEESIERVYSIED--------- 572

  Fly   693 PQDLLRQYIVYAKENIRPKLTNIDEDKIAKMYAQLRQ---ESFATGSLPITVRHIESVIRMSEAH 754
                :::|:::|:: .:||:|...|:.|.:.|.:|||   ...|..|..||||.:||:||:||:.
 Frog   573 ----IQRYLLFARQ-FQPKITKEAEEFIVEQYRRLRQRDGSGVAKSSWRITVRQLESLIRLSESM 632

  Fly   755 ARMHLRENVMEADVSMAIRMMLESFI 780
            ||||..:.|....|..|.|::.:|.|
 Frog   633 ARMHCSDEVQPKHVKEAFRLLSKSII 658

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:372227	3/4 (75%)
		MCM_N	184..270	CDD:379644	15/91 (16%)
		MCM	276..780	CDD:214631	194/553 (35%)
mcm6	NP_001016221.1	MCM_N	31..117	CDD:379644	14/89 (16%)
		MCM	123..658	CDD:214631	194/551 (35%)
		Arginine finger	529..532		2/2 (100%)
		MCM6_C	710..819	CDD:375690

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920