Protein Alignment Mcm2 and MCM6

DIOPT Version :9

• Sequence 1: NP_477121.1
• Gene: Mcm2 / 40973
• FlyBaseID: FBgn0014861
• Length: 887
• Species: Drosophila melanogaster
• Sequence 2: NP_005906.2
• Gene: MCM6 / 4175
• HGNCID: 6949
• Length: 821
• Species: Homo sapiens
• Alignment Length: 668
• Identity: 223/668 - (33%)
• Similarity: 353/668 - (52%)
• Gaps: 87/668 - (13%)

  Fly   177 RTEIANR----FQSFLRTFVDERGAYTYRDRIRRMCEQNMSSFVVSYTDLANKEHVLAYFLPEAP 237
            |.|:|.:    |..||..|....|...|......:.....::.|||:.||......|:..:.|..
Human    19 RDEVAEKCQKLFLDFLEEFQSSDGEIKYLQLAEELIRPERNTLVVSFVDLEQFNQQLSTTIQEEF 83

  Fly   238 FQM-------LEIFDKVAKDMVLSIFPTYERVTTEIHVRISELPLIEELRTFRKLHLNQLVRTLG 295
            :::       |:.|.|..|::.|:         .:.:|...:||...::|......:..|.|..|
Human    84 YRVYPYLCRALKTFVKDRKEIPLA---------KDFYVAFQDLPTRHKIRELTSSRIGLLTRISG 139

  Fly   296 VVTATTGVLPQLSVIKYDCVKCGYVLGPFVQSQNTEIKPGSC--PECQSTGPFSINMEQTLYRNY 358
            .|..|..|.|:|....:.|:.|..|:.. |:.|....:|..|  |.|.:...|.::..::.:.::
Human   140 QVVRTHPVHPELVSGTFLCLDCQTVIRD-VEQQFKYTQPNICRNPVCANRRRFLLDTNKSRFVDF 203

  Fly   359 QKITLQESPGRIPAGRIPRSKDVILLADLCDQCKPGDELEVTGIY-----------------TNN 406
            ||:.:||:...:|.|.||||.:|||.|:..:..:.||:.:.||..                 ||:
Human   204 QKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGDKCDFTGTLIVVPDVSKLSTPGARAETNS 268

  Fly   407 ----YDGSLNTD--QGFPVFATVIIANHVV-----------------VKDSKQVVQS----LTDE 444
                .|| ..|:  :|........::..:|                 ::|.:|..:|    :|.:
Human   269 RVSGVDG-YETEGIRGLRALGVRDLSYRLVFLACCVAPTNPRFGGKELRDEEQTAESIKNQMTVK 332

  Fly   445 DIATIQKLSKDPRIVERVVASMAPSIYGHDYIKRALALALFGGESKNPGEKHKVRGDINLLICGD 509
            :...:.::|:|..:...:..|:.|:|:|:|.:||.:.|.||||..|..||...:|||||:.|.||
Human   333 EWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTGEGTSLRGDINVCIVGD 397

  Fly   510 PGTAKSQFLKYTEKVAPRAVFTTGQGASAVGLTAYVRRNPVSREWTLEAGALVLADQGVCLIDEF 574
            |.||||||||:.|:.:||||:|:|:.:||.||||.|.|:..|.|:.:|||||:|||.|||.||||
Human   398 PSTAKSQFLKHVEEFSPRAVYTSGKASSAAGLTAAVVRDEESHEFVIEAGALMLADNGVCCIDEF 462

  Fly   575 DKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSMTFSENVNLSEPIL 639
            |||:.:|:.:||||||||:|||:|||:..:|.||.:::||||||.|.||.|.:..:|:|||.||:
Human   463 DKMDVRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPISGHYDRSKSLKQNINLSAPIM 527

  Fly   640 SRFDVLCVVKDEFDPMQDQQLAKFVVHSHMKHHPSEEEQPELEEPQLKTVDEI-PQDLLRQYIVY 703
            ||||:..::.||.:.:.|..:|:.:|..|.:          :||    ::|.: ..|.:|:|:::
Human   528 SRFDLFFILVDECNEVTDYAIARRIVDLHSR----------IEE----SIDRVYSLDDIRRYLLF 578

  Fly   704 AKENIRPKLTNIDEDKIAKMYAQLRQ---ESFATGSLPITVRHIESVIRMSEAHARMHLRENVME 765
            |:: .:||::...||.|.:.|..|||   ......|..||||.:||:||:|||.||||..:.|..
Human   579 ARQ-FKPKISKESEDFIVEQYKHLRQRDGSGVTKSSWRITVRQLESMIRLSEAMARMHCCDEVQP 642

  Fly   766 ADVSMAIRMMLESFIEAQ 783
            ..|..|.|::.:|.|..:
Human   643 KHVKEAFRLLNKSIIRVE 660

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:372227
		MCM_N	184..270	CDD:379644	19/92 (21%)
		MCM	276..780	CDD:214631	198/553 (36%)
MCM6	NP_005906.2	MCM_N	27..114	CDD:405270	19/95 (20%)
		MCM	119..657	CDD:214631	198/554 (36%)
		Arginine finger	528..531		2/2 (100%)
		MCM6_C	713..817	CDD:408078

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820