Protein Alignment Mcm2 and MCM4

DIOPT Version :10

• Sequence 1: NP_477121.1
• Gene: Mcm2 / 40973
• FlyBaseID: FBgn0014861
• Length: 887
• Species: Drosophila melanogaster
• Sequence 2: NP_005905.2
• Gene: MCM4 / 4173
• HGNCID: 6947
• Length: 863
• Species: Homo sapiens
• Alignment Length: 940
• Identity: 276/940 - (29%)
• Similarity: 438/940 - (46%)
• Gaps: 162/940 - (17%)

  Fly     6 SPPPNTPSDAAERRDLRAAMTSPVGDFEPFENEDEILGDQTVRDE------AEEEDGEELFGDNM 64
            |.|.:|||    ||..|....:|.               ||.|.|      ::...||:   ...
Human     2 SSPASTPS----RRGSRRGRATPA---------------QTPRSEDARSSPSQRRRGED---STS 44

  Fly    65 ENDYRPMPE---LDHYDPALLD----------------DEDDFSEMSQGDRFA-AESEMRRRDRA 109
            ..:.:|||.   :|...||..|                |.|..|.::.|...: .|...|...|.
Human    45 TGELQPMPTSPGVDLQSPAAQDVLFSSPPQMHSSAIPLDFDVSSPLTYGTPSSRVEGTPRSGVRG 109

  Fly   110 AGIHRDDRDLGFGQSDDEDDVGPRAKRRAGEKAAVGEVEDTEMVESIENLEDTKGHSTKEWVSML 174
            ..: |...|||..|...:.|:                ..|....|.|...|.:.|.....|
Human   110 TPV-RQRPDLGSAQKGLQVDL----------------QSDGAAAEDIVASEQSLGQKLVIW---- 153

  Fly   175 GPRTEIA---NRFQSFLRTFVDERGA--------YTYRDRIRRMCEQNMSSFVVSYTDL-ANKEH 227
            |....:|   ..||.||:.|:|....        .|....::|:.|.|    |:....| .|.||
Human   154 GTDVNVAACKENFQRFLQRFIDPLAKEEENVGIDITEPLYMQRLGEIN----VIGEPFLNVNCEH 214

  Fly   228 VLAY------FLPEAPFQMLEIFDKVAKDMVLSIFPTYERVTTEIHVRISELPLIEELRTFRKLH 286
            :.::      .|...|.:::..||....::....:|. ..:..:|.||.......:.:|......
Human   215 IKSFDKNLYRQLISYPQEVIPTFDMAVNEIFFDRYPD-SILEHQIQVRPFNALKTKNMRNLNPED 278

  Fly   287 LNQLVRTLGVVTATTGVLPQLSVIKYDCVKCGYVLGPFVQSQNTEI-KPGSCPECQSTGPFSINM 350
            ::||:...|:|..|:.::|::....:.|..|.:...  |:.....| :|..|..|.:|...::..
Human   279 IDQLITISGMVIRTSQLIPEMQEAFFQCQVCAHTTR--VEMDRGRIAEPSVCGRCHTTHSMALIH 341

  Fly   351 EQTLYRNYQKITLQESPGRIPAGRIPRSKDVILLA--DLCDQCKPGDELEVTGIY------TNNY 407
            .::|:.:.|.|.|||||..:|||:.|.:  |||.|  ||.|:.:|||.:.|||||      .|..
Human   342 NRSLFSDKQMIKLQESPEDMPAGQTPHT--VILFAHNDLVDKVQPGDRVNVTGIYRAVPIRVNPR 404

  Fly   408 DGSLNTDQGFPVFATVIIANHVVVKDSK-------QVVQSL-TDEDIATIQKLSKDPRIVERVVA 464
            ..::.:     |:.|.|...|....|:|       :..|.| :::.:..:::||:.|.|.||:.:
Human   405 VSNVKS-----VYKTHIDVIHYRKTDAKRLHGLDEEAEQKLFSEKRVELLKELSRKPDIYERLAS 464

  Fly   465 SMAPSIYGHDYIKRALALALFGGESKNPGE--KHKVRGDINLLICGDPGTAKSQFLKYTEKVAPR 527
            ::|||||.|:.||:.:.|.||||..|:...  :.|.|.:||:|:||||||:|||.|:|...:.||
Human   465 ALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYVYNLVPR 529

  Fly   528 AVFTTGQGASAVGLTAYVRRNPVSREWTLEAGALVLADQGVCLIDEFDKMNDQDRTSIHEAMEQQ 592
            ..:|:|:|:|||||||||.::|.:|:..|:.|||||:|.|:|.||||||||:..|:.:||.||||
Human   530 GQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQ 594

  Fly   593 SISISKAGIVTSLQARCTVIAAANPIGGRYDPSMTFSENVNLSEPILSRFDVLCVVKDEFDPMQD 657
            ::||:||||:..|.||.:|:||||||..:::|..|..||:.|...:|||||::.::.|..|...|
Human   595 TLSIAKAGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLLLDPQDEAYD 659

  Fly   658 QQLAKFVVHSHMKHHPSEEEQPELEEPQLKTVDEIPQDLLRQYIVYAKENIRPKLTNIDEDKIAK 722
            ::||..:|   ..::.|||:..|         :.:...:|:.||.||...|.|:|:......:.:
Human   660 RRLAHHLV---ALYYQSEEQAEE---------ELLDMAVLKDYIAYAHSTIMPRLSEEASQALIE 712

  Fly   723 MYAQLRQESFATGSLPITVRHIESVIRMSEAHARMHLRENVMEADVSMAIRMMLESFIEAQ---- 783
            .|..:|:...:.|.:....|.:||:||::||||::.|...|...||..|.|:..|:..::.
Human   713 AYVDMRKIGSSRGMVSAYPRQLESLIRLAEAHAKVRLSNKVEAIDVEEAKRLHREALKQSATDPR 777

  Fly   784 ----KFSVMKK-MRSTFQKYLSFQKDHSELLFFILRQLTLDQ-----LAYIRC-KDGPGATHVEI 837
                ..|::.. |.:|.:|       ..|.|...|::|.|.:     |.|.:. :|..|.:.:.|
Human   778 TGIVDISILTTGMSATSRK-------RKEELAEALKKLILSKGKTPALKYQQLFEDIRGQSDIAI 835

  Fly   838 MERDLIERAKQLDIVNLKPFYESDLFRTNG 867
             .:|:.|.|       |:...:.|.....|
Human   836 -TKDMFEEA-------LRALADDDFLTVTG 857

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:403724	25/126 (20%)
		MCM_N	182..271	CDD:464206	23/103 (22%)
		MCM	276..780	CDD:214631	190/522 (36%)
MCM4	NP_005905.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..60		19/79 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	91..126		9/35 (26%)
		MCM_N	163..264	CDD:464206	23/105 (22%)
		MCM	267..770	CDD:214631	190/523 (36%)
		Arginine finger	642..645		2/2 (100%)