DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mcm2 and MCM4

DIOPT Version :9

Sequence 1:NP_477121.1 Gene:Mcm2 / 40973 FlyBaseID:FBgn0014861 Length:887 Species:Drosophila melanogaster
Sequence 2:NP_005905.2 Gene:MCM4 / 4173 HGNCID:6947 Length:863 Species:Homo sapiens


Alignment Length:940 Identity:276/940 - (29%)
Similarity:438/940 - (46%) Gaps:162/940 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 SPPPNTPSDAAERRDLRAAMTSPVGDFEPFENEDEILGDQTVRDE------AEEEDGEELFGDNM 64
            |.|.:|||    ||..|....:|.               ||.|.|      ::...||:   ...
Human     2 SSPASTPS----RRGSRRGRATPA---------------QTPRSEDARSSPSQRRRGED---STS 44

  Fly    65 ENDYRPMPE---LDHYDPALLD----------------DEDDFSEMSQGDRFA-AESEMRRRDRA 109
            ..:.:|||.   :|...||..|                |.|..|.::.|...: .|...|...|.
Human    45 TGELQPMPTSPGVDLQSPAAQDVLFSSPPQMHSSAIPLDFDVSSPLTYGTPSSRVEGTPRSGVRG 109

  Fly   110 AGIHRDDRDLGFGQSDDEDDVGPRAKRRAGEKAAVGEVEDTEMVESIENLEDTKGHSTKEWVSML 174
            ..: |...|||..|...:.|:                ..|....|.|...|.:.|.....|    
Human   110 TPV-RQRPDLGSAQKGLQVDL----------------QSDGAAAEDIVASEQSLGQKLVIW---- 153

  Fly   175 GPRTEIA---NRFQSFLRTFVDERGA--------YTYRDRIRRMCEQNMSSFVVSYTDL-ANKEH 227
            |....:|   ..||.||:.|:|....        .|....::|:.|.|    |:....| .|.||
Human   154 GTDVNVAACKENFQRFLQRFIDPLAKEEENVGIDITEPLYMQRLGEIN----VIGEPFLNVNCEH 214

  Fly   228 VLAY------FLPEAPFQMLEIFDKVAKDMVLSIFPTYERVTTEIHVRISELPLIEELRTFRKLH 286
            :.::      .|...|.:::..||....::....:|. ..:..:|.||.......:.:|......
Human   215 IKSFDKNLYRQLISYPQEVIPTFDMAVNEIFFDRYPD-SILEHQIQVRPFNALKTKNMRNLNPED 278

  Fly   287 LNQLVRTLGVVTATTGVLPQLSVIKYDCVKCGYVLGPFVQSQNTEI-KPGSCPECQSTGPFSINM 350
            ::||:...|:|..|:.::|::....:.|..|.:...  |:.....| :|..|..|.:|...::..
Human   279 IDQLITISGMVIRTSQLIPEMQEAFFQCQVCAHTTR--VEMDRGRIAEPSVCGRCHTTHSMALIH 341

  Fly   351 EQTLYRNYQKITLQESPGRIPAGRIPRSKDVILLA--DLCDQCKPGDELEVTGIY------TNNY 407
            .::|:.:.|.|.|||||..:|||:.|.:  |||.|  ||.|:.:|||.:.|||||      .|..
Human   342 NRSLFSDKQMIKLQESPEDMPAGQTPHT--VILFAHNDLVDKVQPGDRVNVTGIYRAVPIRVNPR 404

  Fly   408 DGSLNTDQGFPVFATVIIANHVVVKDSK-------QVVQSL-TDEDIATIQKLSKDPRIVERVVA 464
            ..::.:     |:.|.|...|....|:|       :..|.| :::.:..:::||:.|.|.||:.:
Human   405 VSNVKS-----VYKTHIDVIHYRKTDAKRLHGLDEEAEQKLFSEKRVELLKELSRKPDIYERLAS 464

  Fly   465 SMAPSIYGHDYIKRALALALFGGESKNPGE--KHKVRGDINLLICGDPGTAKSQFLKYTEKVAPR 527
            ::|||||.|:.||:.:.|.||||..|:...  :.|.|.:||:|:||||||:|||.|:|...:.||
Human   465 ALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYVYNLVPR 529

  Fly   528 AVFTTGQGASAVGLTAYVRRNPVSREWTLEAGALVLADQGVCLIDEFDKMNDQDRTSIHEAMEQQ 592
            ..:|:|:|:|||||||||.::|.:|:..|:.|||||:|.|:|.||||||||:..|:.:||.||||
Human   530 GQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQ 594

  Fly   593 SISISKAGIVTSLQARCTVIAAANPIGGRYDPSMTFSENVNLSEPILSRFDVLCVVKDEFDPMQD 657
            ::||:||||:..|.||.:|:||||||..:::|..|..||:.|...:|||||::.::.|..|...|
Human   595 TLSIAKAGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLLLDPQDEAYD 659

  Fly   658 QQLAKFVVHSHMKHHPSEEEQPELEEPQLKTVDEIPQDLLRQYIVYAKENIRPKLTNIDEDKIAK 722
            ::||..:|   ..::.|||:..|         :.:...:|:.||.||...|.|:|:......:.:
Human   660 RRLAHHLV---ALYYQSEEQAEE---------ELLDMAVLKDYIAYAHSTIMPRLSEEASQALIE 712

  Fly   723 MYAQLRQESFATGSLPITVRHIESVIRMSEAHARMHLRENVMEADVSMAIRMMLESFIEAQ---- 783
            .|..:|:...:.|.:....|.:||:||::||||::.|...|...||..|.|:..|:..::.    
Human   713 AYVDMRKIGSSRGMVSAYPRQLESLIRLAEAHAKVRLSNKVEAIDVEEAKRLHREALKQSATDPR 777

  Fly   784 ----KFSVMKK-MRSTFQKYLSFQKDHSELLFFILRQLTLDQ-----LAYIRC-KDGPGATHVEI 837
                ..|::.. |.:|.:|       ..|.|...|::|.|.:     |.|.:. :|..|.:.:.|
Human   778 TGIVDISILTTGMSATSRK-------RKEELAEALKKLILSKGKTPALKYQQLFEDIRGQSDIAI 835

  Fly   838 MERDLIERAKQLDIVNLKPFYESDLFRTNG 867
             .:|:.|.|       |:...:.|.....|
Human   836 -TKDMFEEA-------LRALADDDFLTVTG 857

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mcm2NP_477121.1 MCM2_N 59..166 CDD:372227 25/126 (20%)
MCM_N 184..270 CDD:379644 22/100 (22%)
MCM 276..780 CDD:214631 190/522 (36%)
MCM4NP_005905.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..60 19/79 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 91..126 9/35 (26%)
MCM_N 163..263 CDD:405270 23/104 (22%)
MCM 267..770 CDD:214631 190/523 (36%)
Arginine finger 642..645 2/2 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1241
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54431
OrthoDB 1 1.010 - - D232729at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.830

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