DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm2 and MCM2

DIOPT Version :9

Sequence 1:	NP_477121.1	Gene:	Mcm2 / 40973	FlyBaseID:	FBgn0014861	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	NP_004517.2	Gene:	MCM2 / 4171	HGNCID:	6944	Length:	904	Species:	Homo sapiens

Alignment Length:	891	Identity:	571/891 - (64%)
Similarity:	710/891 - (79%)	Gaps:	25/891 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SSPPPNTPSDAAERRDLRAAMTSPVGDFEPFENEDE-ILGDQTVRDEAEEEDGEELFGDNMENDY 68
            :.|..::|..::.|.|  |..:||..|..|||:|.| :||.:...:  ||||||||.||.||.||
Human    21 NDPLTSSPGRSSRRTD--ALTSSPGRDLPPFEDESEGLLGTEGPLE--EEEDGEELIGDGMERDY 81

  Fly    69 RPMPELDHYD-PALLDDEDDFSEMSQGDRFAAESEMRRRDRAAGIHRDDRDLG------FGQSDD 126
            |.:||||.|: ..|..|::|..|::...|.|||..||:|||.||     |.||      ...||:
Human    82 RAIPELDAYEAEGLALDDEDVEELTASQREAAERAMRQRDREAG-----RGLGRMRRGLLYDSDE 141

  Fly   127 EDDVGPRAKRRAGEKAAVGEVEDTEMVESIENLEDTKGHSTKEWVSMLGPRTEIANRFQSFLRTF 191
            ||:..|..|||..|:|.....||.||:||||||||.||||.:|||||.|||.||.:||::||||.
Human   142 EDEERPARKRRQVERATEDGEEDEEMIESIENLEDLKGHSVREWVSMAGPRLEIHHRFKNFLRTH 206

  Fly   192 VDERGAYTYRDRIRRMCEQNMSSFVVSYTDLANKEHVLAYFLPEAPFQMLEIFDKVAKDMVLSIF 256
            ||..|...:::||..||::|..|.||:|.|||.:||||||||||||.::|:|||:.|.::||:::
Human   207 VDSHGHNVFKERISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQIFDEAALEVVLAMY 271

  Fly   257 PTYERVTTEIHVRISELPLIEELRTFRKLHLNQLVRTLGVVTATTGVLPQLSVIKYDCVKCGYVL 321
            |.|:|:|..||||||.|||:||||:.|:||||||:||.||||:.||||||||::||:|.||.:||
Human   272 PKYDRITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLSMVKYNCNKCNFVL 336

  Fly   322 GPFVQSQNTEIKPGSCPECQSTGPFSINMEQTLYRNYQKITLQESPGRIPAGRIPRSKDVILLAD 386
            |||.||||.|:||||||||||.|||.:|||:|:|:|||:|.:|||||::.|||:|||||.|||||
Human   337 GPFCQSQNQEVKPGSCPECQSAGPFEVNMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAILLAD 401

  Fly   387 LCDQCKPGDELEVTGIYTNNYDGSLNTDQGFPVFATVIIANHVVVKDSKQVVQSLTDEDIATIQK 451
            |.|.||||||:|:||||.|||||||||..|||||||||:||||..||:|..|..|||||:..|..
Human   402 LVDSCKPGDEIELTGIYHNNYDGSLNTANGFPVFATVILANHVAKKDNKVAVGELTDEDVKMITS 466

  Fly   452 LSKDPRIVERVVASMAPSIYGHDYIKRALALALFGGESKNPGEKHKVRGDINLLICGDPGTAKSQ 516
            ||||.:|.|::.||:|||||||:.|||.|||||||||.||||.|||||||||:|:||||||||||
Human   467 LSKDQQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGTAKSQ 531

  Fly   517 FLKYTEKVAPRAVFTTGQGASAVGLTAYVRRNPVSREWTLEAGALVLADQGVCLIDEFDKMNDQD 581
            ||||.|||:.||:||||||||||||||||:|:|||||||||||||||||:|||||||||||||||
Human   532 FLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQD 596

  Fly   582 RTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSMTFSENVNLSEPILSRFDVLC 646
            ||||||||||||||||||||||||||||||||||||||||||||:||||||:|:|||:||||:||
Human   597 RTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDILC 661

  Fly   647 VVKDEFDPMQDQQLAKFVVHSHMKHHPSEEEQPEL-----EEPQLKT---VDEIPQDLLRQYIVY 703
            ||:|..||:||:.||:|||.||::||||.:|:..|     .||.:..   |:.:||::|::||:|
Human   662 VVRDTVDPVQDEMLARFVVGSHVRHHPSNKEEEGLANGSAAEPAMPNTYGVEPLPQEVLKKYIIY 726

  Fly   704 AKENIRPKLTNIDEDKIAKMYAQLRQESFATGSLPITVRHIESVIRMSEAHARMHLRENVMEADV 768
            |||.:.|||..:|:||:||||:.||:||.||||:|||||||||:|||:|||||:|||:.|:|.||
Human   727 AKERVHPKLNQMDQDKVAKMYSDLRKESMATGSIPITVRHIESMIRMAEAHARIHLRDYVIEDDV 791

  Fly   769 SMAIRMMLESFIEAQKFSVMKKMRSTFQKYLSFQKDHSELLFFILRQLTLDQLAYIRCKDGPGAT 833
            :||||:||||||:.||||||:.||.||.:||||::|::|||.|||:||..:|:.|.|.:.|....
Human   792 NMAIRVMLESFIDTQKFSVMRSMRKTFARYLSFRRDNNELLLFILKQLVAEQVTYQRNRFGAQQD 856

  Fly   834 HVEIMERDLIERAKQLDIVNLKPFYESDLFRTNGFSYDPKRRIILQ 879
            .:|:.|:||:::|:|::|.||..||:|:|||.|.||:|.||::|||
Human   857 TIEVPEKDLVDKARQINIHNLSAFYDSELFRMNKFSHDLKRKMILQ 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:372227	55/113 (49%)
		MCM_N	184..270	CDD:379644	46/85 (54%)
		MCM	276..780	CDD:214631	376/511 (74%)
MCM2	NP_004517.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..80		27/62 (44%)
		Interaction with KAT7. /evidence=ECO:0000250	2..257		122/244 (50%)
		MCM2_N	73..182	CDD:403724	55/113 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	109..167		26/62 (42%)
		MCM_N	197..286	CDD:405270	48/88 (55%)
		MCM	291..803	CDD:214631	376/511 (74%)
		Arginine finger	655..658		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	686..705		7/18 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159411
Domainoid	1	1.000	374	1.000	Domainoid score	I886
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3325
Inparanoid	1	1.050	1138	1.000	Inparanoid score	I218
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54431
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	1	1.000	-	-		FOG0004149
OrthoInspector	1	1.000	-	-		oto91837
orthoMCL	1	0.900	-	-		OOG6_101336
Panther	1	1.100	-	-	LDO	PTHR11630
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3415
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770