Protein Alignment Mcm2 and Mcm5

DIOPT Version :9

• Sequence 1: NP_477121.1
• Gene: Mcm2 / 40973
• FlyBaseID: FBgn0014861
• Length: 887
• Species: Drosophila melanogaster
• Sequence 2: NP_524308.2
• Gene: Mcm5 / 41296
• FlyBaseID: FBgn0017577
• Length: 733
• Species: Drosophila melanogaster
• Alignment Length: 637
• Identity: 217/637 - (34%)
• Similarity: 349/637 - (54%)
• Gaps: 50/637 - (7%)

  Fly   180 IANRFQSFLRTFVDERGAYTYRDRIRRMCEQNMSSFVVSYTDLANKEHVLAYFLPEAPFQMLEIF 244
            :..:::.|:|||.:|...|.|||.::|..........:...||...:..||..|.:.|.:.||||
  Fly    30 VKKKYKEFIRTFNEENFFYKYRDTLKRNYLNGRYFLEIEMEDLVGFDETLADKLNKQPTEHLEIF 94

  Fly   245 DKVAK---DMVLSIFPTYERVTTEIHVRISELPLIEELRTFRKLHLNQLVRTLGVVTATTGVLPQ 306
            ::.|:   |.:.:..|.:|....:|.:.:|.......:|..:...:::||:..|::.|.:|:..:
  Fly    95 EEAAREVADEITAPRPEHEEHMHDIQILLSSNANPTNIRQLKSDCVSKLVKIAGIIVAASGISAK 159

  Fly   307 LSVIKYDCVKCGYVLGPFVQSQNTEIKPG--------SC-------PECQSTGPFSINMEQTLYR 356
            .:.:...|:.|..|:      .|.::.||        .|       |:| ...||.|..::....
  Fly   160 ATRMSIQCLSCSTVI------PNLKVNPGLEGYALPRKCNTEQAGRPKC-PLDPFFIMPDKCKCV 217

  Fly   357 NYQKITLQESPGRIPAGRIPRSKDVILLADLCDQCKPGDELEVTGIYTNNYDGSLNTDQGFPVFA 421
            ::|.:.|||.|..:|.|.|||...:.....||::..||:.:.:.|||:....|..:...|.....
  Fly   218 DFQTLKLQELPDFVPQGEIPRHLQLFCDRSLCERVVPGNRVLIQGIYSIRKVGKPSRRDGREKAV 282

  Fly   422 TVIIANHV----VVKDSKQV-----VQSLTDEDIATIQKLSKDPRIVERVVASMAPSIYGHDYIK 477
            ..:.|.::    :..||:..     ..::|.::....::::....|.||:..|:||||:|...||
  Fly   283 VGVRAPYMRVVGITVDSEGAGAISRYSNITSDEEEHFRRMAASGDIYERLSQSLAPSIFGSRDIK 347

  Fly   478 RALALALFGGESKNPGEKHKVRGDINLLICGDPGTAKSQFLKYTEKVAPRAVFTTGQGASAVGLT 542
            :|:...||||..|...:....|||||:|:.|||||||||.||:.|||||.||:|:|:|:||.|||
  Fly   348 KAITCMLFGGSRKRLPDGLCRRGDINVLLLGDPGTAKSQLLKFVEKVAPIAVYTSGKGSSAAGLT 412

  Fly   543 AYVRRNPVSREWTLEAGALVLADQGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQA 607
            |.|.::|.:|.:.:|.||:||||.||..|||||||.:.||.:||||||||:|||:||||.|:|.:
  Fly   413 ASVMKDPQTRNFVMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNS 477

  Fly   608 RCTVIAAANPIGGRYDPSMTFSENVNLSEPILSRFDVLCVVKDEFDPMQDQQLAKFVVHSHMKHH 672
            ||:|:||||.|.||:|.:.. .||::....||||||::.:|||..|..:|..|||.:::.|:..:
  Fly   478 RCSVLAAANSIFGRWDDTKG-EENIDFMPTILSRFDMIFIVKDIHDESRDITLAKHIINVHLSSN 541

  Fly   673 PSEEEQPELEEPQLKTVDEIPQDLLRQYIVYAKENIRPKLTNIDEDKIAKMYAQLR----QESFA 733
            .|...:|...|..|.|        .::||.|.:.:..|:|:....:|:...|..:|    |:..|
  Fly   542 KSAPSEPAEGEISLST--------FKKYIHYCRTHCGPRLSEAAGEKLKSRYVLMRSGAGQQEKA 598

  Fly   734 TG---SLPITVRHIESVIRMSEAHARMHLRENVMEADVSMAIRMMLESFIEA 782
            :.   |:|||||.:|:|||:||:.|::.|:....:..|:.|:|:...|.::|
  Fly   599 SDKRLSIPITVRQLEAVIRISESLAKIRLQPFATDEHVNEALRLFQVSTLDA 650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:372227
		MCM_N	184..270	CDD:379644	25/88 (28%)
		MCM	276..780	CDD:214631	190/534 (36%)
Mcm5	NP_524308.2	MCM_N	31..124	CDD:405270	25/92 (27%)
		MCM	128..648	CDD:214631	190/535 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469740
Domainoid	1	1.000	52	1.000	Domainoid score	I661
eggNOG	1	0.900	-	-		E1_COG1241
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D15169at50557
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11630
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850