DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm2 and Mcm7

DIOPT Version :9

Sequence 1:	NP_477121.1	Gene:	Mcm2 / 40973	FlyBaseID:	FBgn0014861	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	NP_523984.1	Gene:	Mcm7 / 39014	FlyBaseID:	FBgn0020633	Length:	720	Species:	Drosophila melanogaster

Alignment Length:	725	Identity:	230/725 - (31%)
Similarity:	366/725 - (50%)	Gaps:	111/725 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 RTEIANRFQSFLRTFVDERGAYTYRDRIRRMCEQNMSSFVVSYTDLANKEHVLAYFLPEAPFQML 241
            |..|......|.:...|.:..:.|..::.::..:......:...|||.....||    ||.....
  Fly    10 RESIKTFLSEFCKCDDDGKKEFVYGSQLVKLAHREQVLITIDLDDLAEFNESLA----EAVVDNC 70

  Fly   242 EIFDKVAKDMVLSIFPTYERVTTEIHVR------------------------------ISEL--- 273
            ..:..:..|::..:.|:|::  .|:|.:                              .|||
  Fly    71 RRYTSIFSDVIAELLPSYKQ--QEVHAKDALDVYIEHRLMMESRTRNPMEQRDERNSFPSELMKR 133

  Fly   274 ------PLIEE----LRTFRKLHLNQLVRTLGVVTATTGVLPQLSVIKYDCVKCGYVLGPFVQSQ 328
                  ||..|    :|..:..|:.:||...|:||..|.|.|.:.|..|.|.:||......|.|.
  Fly   134 FEVGFKPLSTEKAHSIREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTCDRCGSETYQPVNSL 198

  Fly   329 N-TEIKPGSCP--EC---QSTGPFSINMEQTLYRNYQKITLQESPGRIPAGRIPRSKDVILLADL 387
            : |.:.  .||  :|   ::.|...:....:.:..:|::.:||...::|.|.||||..::...::
  Fly   199 SFTPVH--DCPSDDCRVNKAGGRLYLQTRGSKFVKFQEVKMQEHSDQVPVGHIPRSMTIMCRGEV 261

  Fly   388 CDQCKPGDELEVTGIYTN-NYDGSLNTDQGFPVFATVIIANHVVVKDSKQVVQ----SLTDEDIA 447
            ....:|||.:.|:|::.. ...|.....||. :..|.:.|:.::..:....:.    .||.|:
  Fly   262 TRMAQPGDHIVVSGVFLPLMRTGFAQMIQGL-LSETFLQAHRIICINKNDEISDKDAELTPEE-- 323

  Fly   448 TIQKLSKDPRIVERVVASMAPSIYGHDYIKRALALALFGGESKNPGEKHKVRGDINLLICGDPGT 512
             :::|::|. ..||:..|:||.||||..:|:||.|.|.||..|.| :..|:||:||:.:.||||.
  Fly   324 -LEELAQDD-FYERLATSLAPEIYGHLDVKKALLLLLVGGVDKRP-DGMKIRGNINICLMGDPGV 385

  Fly   513 AKSQFLKYTEKVAPRAVFTTGQGASAVGLTAYVRRNPVSREWTLEAGALVLADQGVCLIDEFDKM 577
            ||||.|.|..::|.|:.:|||:|:|.|||||.|.::|::.|.|||.|||||||||||.|||||||
  Fly   386 AKSQLLGYISRLAVRSQYTTGRGSSGVGLTAAVMKDPLTGEMTLEGGALVLADQGVCCIDEFDKM 450

  Fly   578 NDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSMTFSENVNLSEPILSRF 642
            .|||||:|||.||||:|||:||||:|:|.||.:::|||||..|||:|..|..:|:.|...:||||
  Fly   451 ADQDRTAIHEVMEQQTISIAKAGIMTTLNARVSILAAANPAFGRYNPRRTVEQNIQLPAALLSRF 515

  Fly   643 DVLCVVKDEFDPMQDQQLAKFV--VHSHMKHHPSEEEQPELEEPQLKTVDEIPQDLLRQYIVYAK 705
            |:|.:::|:.|...|.:|||.:  ||||.|..|:          ::|.:|   .:|:|:||...|
  Fly   516 DLLWLIQDKPDRDNDLRLAKHITYVHSHSKQPPT----------RVKALD---MNLMRRYINLCK 567

  Fly   706 ENIRPKLTNIDEDKIAKMYAQLRQESFATGSLPIT-VRHIESVIRMSEAHARMHLRENVMEADVS 769
            .. .|.:.:...|.|...|.:||:|:.....:..| .|::..::|:|.|.||:.|.::|.:.||:
  Fly   568 RK-NPTIPDELTDYIVGAYVELRREARNQKDMTFTSARNLLGILRLSTALARLRLSDSVEKDDVA 631

  Fly   770 MAIRMMLESFIEAQKFSVMKKMRSTFQKYLSFQKDH----SELLFFILRQLTLDQLAYIRCKDGP 830
            .|:|:             ::..:.:..:....||.|    |:.:|.|:|:|         ...|.
  Fly   632 EALRL-------------LEMSKDSLNQIHEHQKGHVPNTSDRIFAIVREL---------AGSGK 674

  Fly   831 GATHVEIMER 840
            .....:||:|
  Fly   675 AVKISDIMDR 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:372227
		MCM_N	184..270	CDD:379644	15/115 (13%)
		MCM	276..780	CDD:214631	196/521 (38%)
Mcm7	NP_523984.1	MCM_N	13..97	CDD:379644	16/89 (18%)
Mcm7	NP_523984.1	MCM	145..641	CDD:214631	195/530 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446133
Domainoid	1	1.000	52	1.000	Domainoid score	I661
eggNOG	1	0.900	-	-		E1_COG1241
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D15169at50557
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11630
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850