Protein Alignment Mcm2 and mei-218

DIOPT Version :10

• Sequence 1: NP_477121.1
• Gene: Mcm2 / 40973
• FlyBaseID: FBgn0014861
• Length: 887
• Species: Drosophila melanogaster
• Sequence 2: NP_728052.2
• Gene: mei-218 / 3772646
• FlyBaseID: FBgn0002709
• Length: 1186
• Species: Drosophila melanogaster
• Alignment Length: 523
• Identity: 106/523 - (20%)
• Similarity: 190/523 - (36%)
• Gaps: 139/523 - (26%)

  Fly   325 VQSQNTEIKPGSCPECQ----STGPFSIN----MEQTL----YRNYQKITLQESPGRIPAGRIPR 377
            |.:.|.:|...|.|..|    |..|.||:    :..||    ..|..:..|.||       .|.:
  Fly   675 VGTTNMDIFTSSPPPIQHMSSSRLPSSISGPTQLSHTLSSPPVENQHQQHLWES-------CIHQ 732

  Fly   378 SKDVILLADLCD----QCKP---------GDELEVTGIYTNNY---------DGSLNTDQGFPVF 420
            .:|::....|.|    :.:|         ..|:|.....:.|.         :..|..|.|.|
  Fly   733 DEDLMYSRPLLDMDQEETQPEQQDQEWQWESEIEPPSFQSENQVVADEHGEENAYLAKDAGPP-- 795

  Fly   421 ATVIIANHVVVKDSKQVVQSLTDEDI----ATIQKLS-------KDPRIVERVVASMAPSIYGHD 474
                :..|::.:...|..|.....|:    ::|:||.       .|...|..:.|.::......|
  Fly   796 ----LERHMIFRAPSQHGQEYPKPDLNCVPSSIKKLHHLISSQYSDYSFVYALSAQISQDCVPMD 856

  Fly   475 ---YIKRALALALFGGESKNPGEKHKVRGDINLLICGDPGTAKSQFLKYTEKVAPRAVFTTGQGA 536
               |:|..|..::...||      .:||..|:|.|........::.|....::|||.:     |.
  Fly   857 CFVYLKMILLASIVSIES------DEVRAPISLCIIATDSLMANRLLNKVGQLAPRFL-----GP 910

  Fly   537 SAVGLTAYVRRNPVSREWTLEAGALVLADQGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGI 601
            ...||.......|....| :.|..|:||.|||....::::::......:.:.:|..::.:.:..|
  Fly   911 HEYGLQPTFNALPTRFNW-IVASPLLLAQQGVYYAGDWNRLSKDQGCQLEKCIENGAVPVPQLHI 974

  Fly   602 VTSLQA-------------RCTVIAAANPIGGR--YDPSMTFSENVNLSEPILSRFDV--LCVVK 649
            ...|:|             :...:|...||.|.  |   |....:.:|...|:.:.:.  ..||.
  Fly   975 DQPLKAAVWTYWQPNNSTNQTLALAKLCPIFGLPIY---MGAQASNSLWNSIIQKHNAEGQIVVN 1036

  Fly   650 DEFD-PMQDQQLAKFVVHSHMKHHPSEEEQPELEEPQLKTVDEIPQDLLRQYIVYAKENIRPKLT 713
            |... |..|.::...::|.                 :..|:.:..|.:|::|.|.:::. ||.:.
  Fly  1037 DGLSIPEDDMRMLIHLLHQ-----------------RKTTLTDGAQHMLQKYYVISRKE-RPNVF 1083

  Fly   714 NIDEDKIAKMYAQLRQESFATGSLPITVRHIESVIRMSEAHARMHLRENVMEADVSMAIRMMLES 778
            :      :|.|..|:|                    ::|..|::.||..|:|:||.:|| ...|.
  Fly  1084 S------SKTYIVLKQ--------------------LAECFAKLALRLEVLESDVCVAI-FHCEH 1121

  Fly   779 FIE 781
            |::
  Fly  1122 FVQ 1124

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:403724
		MCM_N	182..271	CDD:464206
		MCM	276..780	CDD:214631	105/520 (20%)
mei-218	NP_728052.2	PTZ00112	122..>417	CDD:240274
		SP1-4_N	<152..>287	CDD:425404
		MCM	862..1116	CDD:475121	62/312 (20%)
		MCM_lid	1044..1116	CDD:465534	21/115 (18%)