DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm2 and dpa

DIOPT Version :9

Sequence 1:	NP_477121.1	Gene:	Mcm2 / 40973	FlyBaseID:	FBgn0014861	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	NP_001286160.1	Gene:	dpa / 35679	FlyBaseID:	FBgn0015929	Length:	866	Species:	Drosophila melanogaster

Alignment Length:	825	Identity:	233/825 - (28%)
Similarity:	388/825 - (47%)	Gaps:	149/825 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 RAAGIHRDDRD----LGFGQSDDEDDV-GPRAKRRAGEKAAVGEVEDTEMVESI-----ENLE-- 160
            |..|.:..:.|    |.:|.......: .||:..|.....|..::...:.:..:     ..||
  Fly    68 RGLGANMSEIDLSSPLNYGTPSSMGSIRTPRSGIRGTPLRARPDIRTDKRIRQVAIGGGSGLEPI 132

  Fly   161 DTKGHSTKEWVSMLGPRTEIA------------NRFQSFLRTFVDERGAYTYRDRIRRMCEQNMS 213
            ..||..|.:.||......::.            ::|:||:..|:|....   :|.|....:.|..
  Fly   133 PEKGSETTDPVSESSQAPQLVVWGTNVVVSQCKSKFKSFIMRFIDPSAE---QDEISENIDVNQP 194

  Fly   214 SFVVSYTDLANKE--------------------HVLAYFLPEAPFQMLEIFDKVAKDMVLSIFPT 258
            .::....::...|                    .::.|     |.:::..||....:|....:|.
  Fly   195 LYLQKLEEIHTLEEPYLNLNCAHLKTFDQDLYRQLICY-----PQEVIPGFDMAINEMFFERYPA 254

  Fly   259 YERVTTEIHVRISELPLIEELRTFRKLHLNQLVRTLGVVTATTGVLPQLSVIKYDCVKCGYVLGP 323
             ..:..:|.||.........:|:.....::||:...|:|..::.|:|::....:.|..|.:
  Fly   255 -ALLEHQIQVRPFNADKTRNMRSLNPEDMDQLISISGMVIRSSNVIPEMREAFFSCNICSF---- 314

  Fly   324 FVQSQNTEI------KPGSCPECQSTGPFSINMEQTLYRNYQKITLQESPGRIPAGRIPRSKDVI 382
               |...|:      :|..|..|.:...|.:...::.:.:.|.:.|||||..:.||:.|.  :|:
  Fly   315 ---STTVEVDRGRINQPTLCTNCNTNHCFRLIHNRSEFTDKQLVKLQESPDDMAAGQTPH--NVL 374

  Fly   383 LLA--DLCDQCKPGDELEVTGIY------TNNYDGSLNTDQGFPVFATVIIANHVVVKDSKQVVQ 439
            |.|  ||.|:.:|||.:.|||||      |.....|:.:     |:.|.:...|....|:|::.:
  Fly   375 LYAHNDLVDKVQPGDRVTVTGIYRATPLKTGGLSSSVKS-----VYKTHVDVVHFRKVDNKRLYE 434

  Fly   440 SLTDED-------IATIQKLSKDPRIVERVVASMAPSIYGHDYIKRALALALFGGESKNPGEKH- 496
            ....:|       :..:|.|:|.|.|.:|:..::|||||.:|.||:.:.|.||||..|    ||
  Fly   435 DEEGKDHIFPPERVELLQLLAKKPDIYDRLARAIAPSIYENDDIKKGILLQLFGGTKK----KHA 495

  Fly   497 -----KVRGDINLLICGDPGTAKSQFLKYTEKVAPRAVFTTGQGASAVGLTAYVRRNPVSREWTL 556
                 ..|.:|:||:||||||:|||.|:|...:.||:.:|:|:|:|||||||||.::|.:|:..|
  Fly   496 TLGRQNFRSEIHLLLCGDPGTSKSQMLQYVFNLVPRSQYTSGRGSSAVGLTAYVTKDPETRQLVL 560

  Fly   557 EAGALVLADQGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGR 621
            :.|||||||.|||.|||||||||..|:.:||.||||::||:||||:..|.||.:::|||||...:
  Fly   561 QTGALVLADNGVCCIDEFDKMNDSTRSVLHEVMEQQTLSIAKAGIICQLNARTSILAAANPAESQ 625

  Fly   622 YDPSMTFSENVNLSEPILSRFDVLCVVKDEFDPMQDQQLAKFVVH-SHMKHHPSEEEQPELEEPQ 685
            ::......:||.|...:|||||::.:|.|..|.:.|::||..:|. .::..|..|:...::
  Fly   626 WNKRKNIIDNVQLPHTLLSRFDLIFLVLDPQDEIFDKRLASHLVSLYYVTRHEEEDTMFDM---- 686

  Fly   686 LKTVDEIPQDLLRQYIVYAKENIRPKLTNIDEDKIAKMYAQLRQESFATGSLPITVRHIESVIRM 750
                     .:||.||.||:|::.|.|::..:.::.:.|..:|:.....|.:....|.:||:||:
  Fly   687 ---------SVLRDYIAYAREHLSPTLSDEAQQRLIQAYVDMRKVGAGRGQISAYPRQLESLIRL 742

  Fly   751 SEAHARMHLRENVMEADVSMAIRMMLES--------------------------------FIEAQ 783
            |||||::.|...|...||..|.|:..|:                                .:.|.
  Fly   743 SEAHAKVRLSNQVELLDVEEAWRLHREALKQSATDPLSGKIDVGILTTGLSTAARKKRADLVAAI 807

  Fly   784 KFSVMKK---MRSTFQKYLSFQKDHSELLFFILRQLTLDQLAYIR 825
            |.::.||   :...:||..|..|:.|:::  |.|:...|.|..::
  Fly   808 KENLKKKGKVLTVPYQKLFSDIKEGSQIM--ITREQFEDALKEVQ 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:372227	13/69 (19%)
		MCM_N	184..270	CDD:379644	17/105 (16%)
		MCM	276..780	CDD:214631	186/563 (33%)
dpa	NP_001286160.1	PHA03307	2..>150	CDD:223039	16/81 (20%)
		MCM_N	168..267	CDD:379644	18/107 (17%)
		MCM	270..772	CDD:214631	186/532 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446137
Domainoid	1	1.000	52	1.000	Domainoid score	I661
eggNOG	1	0.900	-	-		E1_COG1241
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54431
OrthoDB	1	1.010	-	-		D15169at50557
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11630
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.860