DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm2 and mcm4

DIOPT Version :9

Sequence 1:	NP_477121.1	Gene:	Mcm2 / 40973	FlyBaseID:	FBgn0014861	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	NP_944595.2	Gene:	mcm4 / 337598	ZFINID:	ZDB-GENE-030131-9544	Length:	845	Species:	Danio rerio

Alignment Length:	818	Identity:	241/818 - (29%)
Similarity:	395/818 - (48%)	Gaps:	118/818 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 NTPSDAAERRDLRAAMTSPVGDFEPFENEDEILGDQTVRDEAEEEDGEELFGDNMENDYRPMPEL 74
            ::||..:.:||            .|....::.|...:.|..|.:...|          .:|||..
Zfish     2 SSPSSQSRKRD------------PPTPASEDPLSPPSQRSRAHDTSTE----------LQPMPTS 44

  Fly    75 DHYDPALLDDEDDFSEMSQGDRFAAESEMRRRDRAAGIHRDDRDLGFGQSDDEDDVGPRAKRR-- 137
            ...|.:|      ||. ....|...:||:   |.::       .|.:|......:..||:..|
Zfish    45 PAQDASL------FSS-PMAPRSVLQSEI---DASS-------PLMYGTPSSRVEGTPRSGIRGT 92

  Fly   138 -AGEKAAVGEVEDTEMVESIENLEDTKGHSTKEWVSMLGPRTEI----------ANRFQSFLRTF 191
             |.::|.:|.|.....|:.  :.|...|.:........|.|..|          ..:||.||:.|
Zfish    93 PARQRADLGSVRKAPQVDM--HSEPASGDAAVAGDQGAGQRLVIWGTDVNVGTCKEKFQRFLQQF 155

  Fly   192 VD-----ERGA--------YTYR-DRIRRMCEQ--NMSSFVVSYTDLANKEHVLAYFLPEAPFQM 240
            .|     |..|        |..: |.|..:.|.  |::...:...|......::.|     |.::
Zfish   156 TDPDSREEENAGLDLNEPLYMQKLDEISVVGEPVLNVNCTHIQTFDADLYRQLICY-----PQEV 215

  Fly   241 LEIFDKVAKDMVLSIFPTYERVTTEIHVRISELPLIEELRTFRKLHLNQLVRTLGVVTATTGVLP 305
            :..||....::....||. ..:..:|.||.........:|......::||:...|:|..|:.::|
Zfish   216 IPTFDMSVNELFFDRFPD-SVLEHQIQVRPYSAIKTRNMRNLNPEDIDQLITISGMVIRTSQLIP 279

  Fly   306 QLSVIKYDCVKCGYVLGPFVQSQNTEI--------KPGSCPECQSTGPFSINMEQTLYRNYQKIT 362
            ::....:.|..|.:         ||.:        :|..|..|.:|...::...::::.:.|.|.
Zfish   280 EMQEAFFRCQVCAF---------NTRVEVDRGRIAEPAVCRNCNTTHSMALVHNRSVFSDKQMIK 335

  Fly   363 LQESPGRIPAGRIPRSKDVILLADLCDQCKPGDELEVTGIYTNNYDGSLNTDQG--FPVFATVII 425
            |||||..:|||:.|.:..|....||.|:.:|||.:.:|||| ......||..|.  ..|:.|.|.
Zfish   336 LQESPEDMPAGQTPHTTVVYAHNDLVDKVQPGDRVNITGIY-RAAPMRLNPRQSQVKSVYKTHID 399

  Fly   426 ANHVVVKDSKQV-------VQSL-TDEDIATIQKLSKDPRIVERVVASMAPSIYGHDYIKRALAL 482
            |.|....|.|::       .|.| |.|.:|.:::|:..|.:.||:.:::|||||.|:.||:.:.|
Zfish   400 AIHFRKTDEKRLHGLDEDGEQKLFTKERVALLKELAAKPDVYERLSSALAPSIYEHEDIKKGILL 464

  Fly   483 ALFGGESKNPGE--KHKVRGDINLLICGDPGTAKSQFLKYTEKVAPRAVFTTGQGASAVGLTAYV 545
            .||||..|:..:  :...|.::|:|:||||||:|||.|:|...:.||..:|:|:|:|||||||||
Zfish   465 QLFGGTRKDFTQTGRGNFRAEVNILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYV 529

  Fly   546 RRNPVSREWTLEAGALVLADQGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCT 610
            .::|.:|:..|:.|||||:|.|:|.|||||||:|..|:.:||.||||::||:||||:..|.||.:
Zfish   530 MKDPETRQLVLQTGALVLSDNGICCIDEFDKMSDNTRSVLHEVMEQQTLSIAKAGIICQLNARTS 594

  Fly   611 VIAAANPIGGRYDPSMTFSENVNLSEPILSRFDVLCVVKDEFDPMQDQQLAKFVVHSHMKHHPSE 675
            ::|||||:..:::|..|..||:.|...:|||||::.::.|..|...|::||..:|   ..::.||
Zfish   595 ILAAANPVESQWNPKKTTIENIQLPHTLLSRFDLIFLMLDPQDEAYDRRLAHHLV---SLYYQSE 656

  Fly   676 EEQPELEEPQLKTVDEIPQDLLRQYIVYAKENIRPKLTNIDEDKIAKMYAQLRQESFATGSLPIT 740
            |   ::||      :.:...:|:.||.:|:..:.|:|:......:.:.|..:|:.....|.:...
Zfish   657 E---QIEE------EHLDMAVLKDYIAFARTTVHPRLSEEASQALIEAYVDMRKIGSGRGMVSAY 712

  Fly   741 VRHIESVIRMSEAHARMHLRENVMEADVSMAIRMMLES 778
            .|.:||:||::||||::.....|...||..|.|:..|:
Zfish   713 PRQLESLIRLAEAHAKVRFSGKVETIDVEEAKRLHREA 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:372227	23/109 (21%)
		MCM_N	184..270	CDD:379644	22/101 (22%)
		MCM	276..780	CDD:214631	183/523 (35%)
mcm4	NP_944595.2	MCM_N	147..269	CDD:291233	26/127 (20%)
		MCM	249..752	CDD:214631	183/524 (35%)
		P-loop_NTPase	487..626	CDD:304359	74/138 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54431
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.830