Protein Alignment Mcm2 and Mcm3

DIOPT Version :10

• Sequence 1: NP_477121.1
• Gene: Mcm2 / 40973
• FlyBaseID: FBgn0014861
• Length: 887
• Species: Drosophila melanogaster
• Sequence 2: NP_001178734.2
• Gene: Mcm3 / 316273
• RGDID: 1305168
• Length: 813
• Species: Rattus norvegicus
• Alignment Length: 695
• Identity: 230/695 - (33%)
• Similarity: 355/695 - (51%)
• Gaps: 96/695 - (13%)

  Fly   179 EIANRFQSFLRTFVDERGAYTYRDRIRRMCEQNMSSFVVSYTDLANKEHVLAYFLPEAPFQMLEI 243
            |:....:.:|....||.....|::::|.:...|....:|:..||..|....|..|....|:.|..
  Rat    11 ELREAQRDYLDFLDDEEDQGIYQNKVRELISDNQYRLIVNVNDLRRKNEKRANRLLNNAFEELVA 75

  Fly   244 FDKVAKDMVLSIFPTYERVTTEIHVRISELPLIEELRTFRKLHLNQLVRT---LGVVTATTGVLP 305
            |.:..||.|.||..||.:...|.::.:.        .:|...|::....|   |..|....|::.
  Rat    76 FQRALKDFVASIDATYAKQYEEFYIGLE--------GSFGSKHVSPRTLTSCFLSCVVCVEGIVT 132

  Fly   306 QLSVIKYDCVKCGYV--------------LGPFVQSQNTEIKPGSCPECQSTGPFSINMEQTLYR 356
            :.|:::...|:..:.              |...|...::.:.|   .:.:...|.......::|:
  Rat   133 KCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYP---TKDEENNPLETEYGLSVYK 194

  Fly   357 NYQKITLQESPGRIPAGRIPRSKDVILLADLCDQCKPGDELEVTGIY------TNNYDGSLNTDQ 415
            ::|.||:||.|.:.|||::|||.||||..||.|:.||||.::|.|.|      ...|...
  Rat   195 DHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKVKPGDRIQVVGTYRCLPGKKGGYTSG----- 254

  Fly   416 GFPVFATVIIANHVVVKDSKQVVQSLTDEDIATIQKLSK--DPRIVERVVASMAPSIYGHDYIKR 478
               .|.||:||.: |.:.||.:..:.:.:|||.|:|.||  ...:.|::..|:||||:||||:|:
  Rat   255 ---TFRTVLIACN-VKQMSKDIQPAFSADDIAKIKKFSKTRSKDVFEQLARSLAPSIHGHDYVKK 315

  Fly   479 ALALALFGGESKNPGEKHKVRGDINLLICGDPGTAKSQFLKYTEKVAPRAVFTTGQGASAVGLTA 543
            |:...|.||..:.......:|||||:|:.|||..||||.|:|....||||:.|||:|:|.|||||
  Rat   316 AILCLLLGGVERELENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTA 380

  Fly   544 YVRRNPVSREWTLEAGALVLADQGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQAR 608
            .|..:..:.|..|||||:||||:||..|||||||:|.|||:|||.|||..::|:||||...|.||
  Rat   381 AVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNAR 445

  Fly   609 CTVIAAANPIGGRYDPSMTFSENVNLSEPILSRFDVLCVVKDEFDPMQDQQLAKFVVHSHMKHHP 673
            |:|:|||||:.||||...|..||:.|.:.:|||||:|.::.|:.||.||::::..|:..|....|
  Rat   446 CSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHQYRAP 510

  Fly   674 SEEEQPEL-----------EEPQLKTVDEIPQD-------------------------LLRQYIV 702
            .|::...|           ::|.....|:  ||                         .:::||.
  Rat   511 GEQDGDALPLGSSVDILATDDPDFTQDDQ--QDTRIYEKHDNLLHGSKKKREKMVSAAFMKKYIH 573

  Fly   703 YAKENIRPKLTNIDEDKIAKMYAQLR-QESFATGSL---PITVRHIESVIRMSEAHARMHLRENV 763
            .|| .|:|.||......||:.|::|| |:|.::.:.   |:|.|.:|::||::.|||:..:.:.|
  Rat   574 VAK-IIKPTLTQESAAYIAEEYSRLRSQDSMSSDTARTSPVTARTLETLIRLATAHAKARMSKTV 637

  Fly   764 MEADVSMAIRMMLESFIEAQKFSVMKKMRSTFQKYLSFQKDHSEL 808
            ...|.        |..:|..:::..||:....:|.....:|.|:|
  Rat   638 DLQDA--------EEAVELVQYAYFKKVLEKEKKRKKPSEDESDL 674

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:403724
		MCM_N	182..271	CDD:464206	23/88 (26%)
		MCM	276..780	CDD:214631	199/568 (35%)
Mcm3	NP_001178734.2	MCM_N	16..104	CDD:464206	23/95 (24%)
		MCM	109..654	CDD:214631	199/567 (35%)