DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm2 and Mcm3

DIOPT Version :9

Sequence 1:	NP_477121.1	Gene:	Mcm2 / 40973	FlyBaseID:	FBgn0014861	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	NP_001178734.2	Gene:	Mcm3 / 316273	RGDID:	1305168	Length:	813	Species:	Rattus norvegicus

Alignment Length:	695	Identity:	230/695 - (33%)
Similarity:	355/695 - (51%)	Gaps:	96/695 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 EIANRFQSFLRTFVDERGAYTYRDRIRRMCEQNMSSFVVSYTDLANKEHVLAYFLPEAPFQMLEI 243
            |:....:.:|....||.....|::::|.:...|....:|:..||..|....|..|....|:.|..
  Rat    11 ELREAQRDYLDFLDDEEDQGIYQNKVRELISDNQYRLIVNVNDLRRKNEKRANRLLNNAFEELVA 75

  Fly   244 FDKVAKDMVLSIFPTYERVTTEIHVRISELPLIEELRTFRKLHLNQLVRT---LGVVTATTGVLP 305
            |.:..||.|.||..||.:...|.::.:.        .:|...|::....|   |..|....|::.
  Rat    76 FQRALKDFVASIDATYAKQYEEFYIGLE--------GSFGSKHVSPRTLTSCFLSCVVCVEGIVT 132

  Fly   306 QLSVIKYDCVKCGYV--------------LGPFVQSQNTEIKPGSCPECQSTGPFSINMEQTLYR 356
            :.|:::...|:..:.              |...|...::.:.|   .:.:...|.......::|:
  Rat   133 KCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYP---TKDEENNPLETEYGLSVYK 194

  Fly   357 NYQKITLQESPGRIPAGRIPRSKDVILLADLCDQCKPGDELEVTGIY------TNNYDGSLNTDQ 415
            ::|.||:||.|.:.|||::|||.||||..||.|:.||||.::|.|.|      ...|...
  Rat   195 DHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKVKPGDRIQVVGTYRCLPGKKGGYTSG----- 254

  Fly   416 GFPVFATVIIANHVVVKDSKQVVQSLTDEDIATIQKLSK--DPRIVERVVASMAPSIYGHDYIKR 478
               .|.||:||.: |.:.||.:..:.:.:|||.|:|.||  ...:.|::..|:||||:||||:|:
  Rat   255 ---TFRTVLIACN-VKQMSKDIQPAFSADDIAKIKKFSKTRSKDVFEQLARSLAPSIHGHDYVKK 315

  Fly   479 ALALALFGGESKNPGEKHKVRGDINLLICGDPGTAKSQFLKYTEKVAPRAVFTTGQGASAVGLTA 543
            |:...|.||..:.......:|||||:|:.|||..||||.|:|....||||:.|||:|:|.|||||
  Rat   316 AILCLLLGGVERELENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTA 380

  Fly   544 YVRRNPVSREWTLEAGALVLADQGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQAR 608
            .|..:..:.|..|||||:||||:||..|||||||:|.|||:|||.|||..::|:||||...|.||
  Rat   381 AVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNAR 445

  Fly   609 CTVIAAANPIGGRYDPSMTFSENVNLSEPILSRFDVLCVVKDEFDPMQDQQLAKFVVHSHMKHHP 673
            |:|:|||||:.||||...|..||:.|.:.:|||||:|.::.|:.||.||::::..|:..|....|
  Rat   446 CSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHQYRAP 510

  Fly   674 SEEEQPEL-----------EEPQLKTVDEIPQD-------------------------LLRQYIV 702
            .|::...|           ::|.....|:  ||                         .:::||.
  Rat   511 GEQDGDALPLGSSVDILATDDPDFTQDDQ--QDTRIYEKHDNLLHGSKKKREKMVSAAFMKKYIH 573

  Fly   703 YAKENIRPKLTNIDEDKIAKMYAQLR-QESFATGSL---PITVRHIESVIRMSEAHARMHLRENV 763
            .|| .|:|.||......||:.|::|| |:|.::.:.   |:|.|.:|::||::.|||:..:.:.|
  Rat   574 VAK-IIKPTLTQESAAYIAEEYSRLRSQDSMSSDTARTSPVTARTLETLIRLATAHAKARMSKTV 637

  Fly   764 MEADVSMAIRMMLESFIEAQKFSVMKKMRSTFQKYLSFQKDHSEL 808
            ...|.        |..:|..:::..||:....:|.....:|.|:|
  Rat   638 DLQDA--------EEAVELVQYAYFKKVLEKEKKRKKPSEDESDL 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:372227
		MCM_N	184..270	CDD:379644	23/85 (27%)
		MCM	276..780	CDD:214631	199/568 (35%)
Mcm3	NP_001178734.2	MCM_N	17..129	CDD:291233	28/119 (24%)
		MCM	109..654	CDD:214631	199/567 (35%)
		P-loop_NTPase	340..479	CDD:304359	80/138 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820