Protein Alignment Mcm2 and Mcm6

DIOPT Version :9

• Sequence 1: NP_477121.1
• Gene: Mcm2 / 40973
• FlyBaseID: FBgn0014861
• Length: 887
• Species: Drosophila melanogaster
• Sequence 2: NP_511065.1
• Gene: Mcm6 / 31603
• FlyBaseID: FBgn0025815
• Length: 817
• Species: Drosophila melanogaster
• Alignment Length: 682
• Identity: 220/682 - (32%)
• Similarity: 343/682 - (50%)
• Gaps: 104/682 - (15%)

  Fly   171 VSMLGPRTEIANR----FQSFLRTFVDERGAYTYRDRIRRMCEQNMSSFVVSYTDLANKEHVLAY 231
            |..|..:.|:..|    ||.||..| .|.|...|......:...:..:..||:.|:...:..||.
  Fly     8 VGQLRVKDEVGIRAQKLFQDFLEEF-KEDGEIKYTRPAASLESPDRCTLEVSFEDVEKYDQNLAT 71

  Fly   232 FLPEA-----PFQMLEIFDKVAKDMVLSIFPTYERVTTEIHVRISELPLIEELRTFRKLHLNQLV 291
            .:.|.     ||....:.:.|...:.|       :...:.:|..:|:|...::|......:..|:
  Fly    72 AIIEEYYHIYPFLCQSVSNYVKDRIGL-------KTQKDCYVAFTEVPTRHKVRDLTTSKIGTLI 129

  Fly   292 RTLGVVTATTGVLPQLSVIKYDCVKCGYVLGPFVQSQNTEIK----------PGSC--PECQSTG 344
            |..|.|..|..|.|:|....:.|:.|           .|||:          |..|  |.|.:..
  Fly   130 RISGQVVRTHPVHPELVSGVFMCLDC-----------QTEIRNVEQQFKFTNPTICRNPVCSNRK 183

  Fly   345 PFSINMEQTLYRNYQKITLQESPGRIPAGRIPRSKDVILLADLCDQCKPGDELEVTGIYT----- 404
            .|.:::|::|:.::|||.:||:...:|.|.|||:.::||.::|.:..:.||..:.||...
  Fly   184 RFMLDVEKSLFLDFQKIRIQETQAELPRGCIPRAVEIILRSELVETVQAGDRYDFTGTLIVVPDV 248

  Fly   405 -------------------NNYDG----------SLNTDQGF---PVFATV-------IIANHVV 430
                               ...||          .||....|   .|.||.       :..:.|.
  Fly   249 SVLAGVGTRAENSSRHKPGEGMDGVTGLKALGMRELNYRMAFLACSVQATTARFGGTDLPMSEVT 313

  Fly   431 VKDSKQVVQSLTDEDIATIQKLSKDPRIVERVVASMAPSIYGHDYIKRALALALFGGESKNPGEK 495
            .:|.|   :.:||.:...|.::|||..:.:.:::|:.|||||:|.:||.:.|..|||.:|...||
  Fly   314 AEDMK---KQMTDAEWHKIYEMSKDRNLYQNLISSLFPSIYGNDEVKRGILLQQFGGVAKTTTEK 375

  Fly   496 HKVRGDINLLICGDPGTAKSQFLKYTEKVAPRAVFTTGQGASAVGLTAYVRRNPVSREWTLEAGA 560
            ..:|||||:.|.|||.||||||||.....:|||::|:|:.:||.||||.|.|:..|.::.:||||
  Fly   376 TSLRGDINVCIVGDPSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAVVRDEESFDFVIEAGA 440

  Fly   561 LVLADQGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPS 625
            |:|||.|:|.|||||||:.:|:.:||||||||:|||::||:..:|.||.:::||||||.||||.|
  Fly   441 LMLADNGICCIDEFDKMDQRDQVAIHEAMEQQTISIARAGVRATLNARTSILAAANPINGRYDRS 505

  Fly   626 MTFSENVNLSEPILSRFDVLCVVKDEFDPMQDQQLAKFVVHSHMKHHPSEEEQPELEEPQLKTVD 690
            .:..:|:.||.||:||||:..::.||.:.:.|..:|:.:|..|.....|.|.....||
  Fly   506 KSLQQNIQLSAPIMSRFDLFFILVDECNEVVDYAIARKIVDLHSNIEESVERAYTREE------- 563

  Fly   691 EIPQDLLRQYIVYAKENIRPKLTNIDEDKIAKMYAQLRQESFAT---GSLPITVRHIESVIRMSE 752
                 :|| |:.:|:: .:|.::......:.:.|..|||....|   .:..||||.:||:||:||
  Fly   564 -----VLR-YVTFARQ-FKPVISQEAGHMLVENYGHLRQRDTGTSGRSTWRITVRQLESMIRLSE 621

  Fly   753 AHARMHLRENVMEADVSMAIRMMLESFIEAQK 784
            |.|::.....|:|..|..|.|::.:|.|..::
  Fly   622 AMAKLECSNRVLERHVKEAFRLLNKSIIRVEQ 653

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:372227
		MCM_N	184..270	CDD:379644	19/90 (21%)
		MCM	276..780	CDD:214631	194/562 (35%)
Mcm6	NP_511065.1	MCM_N	25..109	CDD:379644	19/91 (21%)
		MCM	113..649	CDD:214631	194/563 (34%)
		MCM6_C	702..816	CDD:375690

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469741
Domainoid	1	1.000	52	1.000	Domainoid score	I661
eggNOG	1	0.900	-	-		E1_COG1241
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D15169at50557
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11630
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850