DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm2 and Mcm4

DIOPT Version :9

Sequence 1:	NP_477121.1	Gene:	Mcm2 / 40973	FlyBaseID:	FBgn0014861	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	NP_387500.1	Gene:	Mcm4 / 29728	RGDID:	3060	Length:	862	Species:	Rattus norvegicus

Alignment Length:	933	Identity:	271/933 - (29%)
Similarity:	434/933 - (46%)	Gaps:	149/933 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SPPPNTPSDAAERRDLRAAMTSPVGDFEPFENEDEILGDQTVRDEAEEE--DGEELFGDNMENDY 68
            |.|.:|||    ||..|....:|.               |::|.|....  .|.....|:...:.
  Rat     2 SSPASTPS----RRSSRRGRVTPT---------------QSLRSEESRSSPSGRRRGEDSSTGEL 47

  Fly    69 RPMPE---LDHYDPALLDDEDDFSEMSQGDRFAAESEMRRRDRAAGIHRD-DRDLGFGQSDDEDD 129
            .|||.   .|...||           :|...|::..:|  ...|..:..| ...|.:|......:
  Rat    48 LPMPTSPGADLQSPA-----------AQNALFSSPPQM--HSSAIPLEFDVSSPLTYGTPSSRVE 99

  Fly   130 VGPRAKRR------------AGEKAAVGEVEDTEMVESIENLEDTKGHSTKEWVSMLGPRTEIA- 181
            ..||:..|            |.:...|....|....|.....|.:.|.....|    |....:|
  Rat   100 GTPRSGVRGTPMRQRPDLGSARKGLQVDLQSDGAAAEDTVASEQSLGQKLVIW----GTDVNVAT 160

  Fly   182 --NRFQSFLRTFVDERGA--------YTYRDRIRRMCEQNMSS--FVVSYTDLANKEHVLAY--- 231
              ..||.||:.|.|....        .|....::|:.|.|::.  |:     ..|.||:.::
  Rat   161 CKEHFQRFLQCFTDPLAKEEENVGIDITQPLYMQRLGEINITGEPFL-----NVNCEHIKSFGKN 220

  Fly   232 ---FLPEAPFQMLEIFDKVAKDMVLSIFPTYERVTTEIHVRISELPLIEELRTFRKLHLNQLVRT 293
               .|...|.:::..||....::....:|. ..:..:|.||.......:.:|......::||:..
  Rat   221 LYRQLISYPQEVIPTFDMAVNEIFFDRYPD-SILEHQIQVRPFNALKTKSMRNLNPEDIDQLITI 284

  Fly   294 LGVVTATTGVLPQLSVIKYDCVKCGYVLGPFVQSQNTEI-KPGSCPECQSTGPFSINMEQTLYRN 357
            .|:|..|:.::|::....:.|..|.:...  |:.....| :|.:|..|.:|...::...::|:.:
  Rat   285 SGMVIRTSQLIPEMQEAFFQCQVCAHTTR--VEMDRGRIAEPCTCVHCHTTHSMALIHNRSLFSD 347

  Fly   358 YQKITLQESPGRIPAGRIPRSKDVILLA--DLCDQCKPGDELEVTGIY------TNNYDGSLNTD 414
            .|.|.|||||..:|||:.|.:  |:|.|  ||.|:.:|||.:.|||||      .|....::.:
  Rat   348 KQMIKLQESPEDMPAGQTPHT--VVLFAHNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVSNVKS- 409

  Fly   415 QGFPVFATVIIANHVVVKDSK-------QVVQSL-TDEDIATIQKLSKDPRIVERVVASMAPSIY 471
                |:.|.|...|....|:|       :..|.| :::.:..:::||:.|.|.||:.:::|||||
  Rat   410 ----VYKTHIDVIHYRKTDAKRLHGLDEEAEQKLFSEKRVKLLKELSRKPDIYERLASALAPSIY 470

  Fly   472 GHDYIKRALALALFGGESKNPGE--KHKVRGDINLLICGDPGTAKSQFLKYTEKVAPRAVFTTGQ 534
            .|:.||:.:.|.||||..|:...  :.|.|.:||:|:||||||:|||.|:|...:.||..:|:|:
  Rat   471 EHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGK 535

  Fly   535 GASAVGLTAYVRRNPVSREWTLEAGALVLADQGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKA 599
            |:|||||||||.::|.:|:..|:.|||||:|.|:|.||||||||:..|:.:||.||||::||:||
  Rat   536 GSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAKA 600

  Fly   600 GIVTSLQARCTVIAAANPIGGRYDPSMTFSENVNLSEPILSRFDVLCVVKDEFDPMQDQQLAKFV 664
            ||:..|.||.:|:||||||..:::|..|..||:.|...:|||||::.::.|..|...|::||..:
  Rat   601 GIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLMLDPQDEAYDRRLAHHL 665

  Fly   665 VHSHMKHHPSEEEQPELEEPQLKTVDEIPQDLLRQYIVYAKENIRPKLTNIDEDKIAKMYAQLRQ 729
            |..:.:    .|||.|.|        .:...:|:.||.||...|.|:|:......:.:.|..:|:
  Rat   666 VSLYYQ----SEEQVEQE--------FLDMAVLKDYIAYAHSTIMPRLSEEASQALIEAYVNMRK 718

  Fly   730 ESFATGSLPITVRHIESVIRMSEAHARMHLRENVMEADVSMAIRMMLESFIEAQ--------KFS 786
            ...:.|.:....|.:||:||::||||::...:.|...||..|.|:..|:..::.        ..|
  Rat   719 IGSSRGMVSAYPRQLESLIRLAEAHAKVRFSDKVEAIDVEEAKRLHREALKQSATDPRTGIVDIS 783

  Fly   787 VMKK-MRSTFQKYLSFQKDHSELLFFILRQLTLDQ-----LAYIRC-KDGPGATHVEIMERDLIE 844
            ::.. |.:|.:|       ..|.|...||:|.|.:     |.|.:. :|..|.:...| .:|:.|
  Rat   784 ILTTGMSATSRK-------RKEELAEALRKLILSKGKTPALKYQQLFEDIRGQSDTAI-TKDMFE 840

  Fly   845 RAKQLDIVNLKPFYESDLFRTNG 867
            .|       |:...:.|.....|
  Rat   841 EA-------LRALADDDFLTVTG 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:372227	23/122 (19%)
		MCM_N	184..270	CDD:379644	21/101 (21%)
		MCM	276..780	CDD:214631	189/522 (36%)
Mcm4	NP_387500.1	MCM_N	165..286	CDD:291233	25/126 (20%)
		MCM	266..769	CDD:214631	189/523 (36%)
		P-loop_NTPase	504..643	CDD:304359	76/138 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54431
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.830