DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm2 and Mcm8

DIOPT Version :9

Sequence 1:	NP_477121.1	Gene:	Mcm2 / 40973	FlyBaseID:	FBgn0014861	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	NP_001099984.1	Gene:	Mcm8 / 296178	RGDID:	1305218	Length:	830	Species:	Rattus norvegicus

Alignment Length:	831	Identity:	252/831 - (30%)
Similarity:	392/831 - (47%)	Gaps:	143/831 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 GQSDDEDDVGPRAKRRAGEKAAVGEVEDTEMVESIENLEDTKGHST--KEWVSMLGPRTEIANRF 184
            |:..|..|:...|...|.|:|:...::.:    :::.....||...  .|..|...|.||....|
  Rat    29 GRWRDRTDLSKAAGNHASEQASQPLLQQS----TLDQFIPYKGWKLYFSEVYSNNSPLTEKIQAF 89

  Fly   185 QSFLRTFVDERGAYTY-RDRIRRMCEQNMSSFVVSYTDLANKEHVLAYFLPEAPFQMLEIFDKVA 248
            :.|....:|     .| :|.|.|     ..|.:|.:.:| .|::.:...:|:....:.:..:|..
  Rat    90 EKFFTRHID-----LYDKDEIER-----KGSILVDFKEL-TKDNEITNLIPDIENALRDAPEKTL 143

  Fly   249 KDMVLSIFPT----YERVTTE-------------------IHVRISELPLIEELRTFRKLHLNQL 290
            ..|.|:|...    .||...|                   |:.|:.....:..|:..|.....:.
  Rat   144 ACMGLAIHQVLTKDLERHAAELQAQEGLCNGGGTMVNVPHIYARVYNYEPLTHLKNIRATCYGKY 208

  Fly   291 VRTLGVVTATTGVLPQLSVIKYDCVKCGYVLGPFVQSQNTEIKPGSC--PECQS-------TGPF 346
            :...|.|...:.:.|..:.:.:.|..||.:.. |.........|..|  |.|:.       :.|.
  Rat   209 ISIRGTVVRVSNIKPLCTKMAFQCAACGEIQS-FPLPDGKYNLPTKCPVPACRGRSFTPLRSSPL 272

  Fly   347 SINMEQTLYRNYQKITLQE--SPGRIPAGRIPRSKDVILLADLCDQCKPGDELEVTGI--YTNNY 407
            ::.|:      :|.|.:||  |..:..||||||:.:..|:.||.|.|.|||.:.||||  .:|:.
  Rat   273 TVTMD------WQLIKIQELMSDAQREAGRIPRTIECELVHDLVDSCVPGDTVTVTGIVKVSNSE 331

  Fly   408 DGSLNTDQGFPVFATVIIANHVVVKDSK-QVVQSLTD------------EDIATIQKLSKDPRIV 459
            :||.:.:... :|...|.||.  |.:|| |..|:..|            :|:..||::..:..::
  Rat   332 EGSRSKNDKC-MFLLYIEANS--VSNSKGQKAQTAEDGCKHGTLMEFSLKDLYAIQEIQAEENLL 393

  Fly   460 ERVVASMAPSIYGHDYIKRALALALFGGESKNPGEKHK--VRGDINLLICGDPGTAKSQFLKYTE 522
            :.:|.|:.|.|:||:.:|..|.||||||..|...:|::  :|||.::||.||||..|||.|:...
  Rat   394 KLIVNSLCPVIFGHELVKAGLMLALFGGSQKYADDKNRIPIRGDPHVLIVGDPGLGKSQMLQAAC 458

  Fly   523 KVAPRAVFTTGQGASAVGLTAYVRRNPVSREWTLEAGALVLADQGVCLIDEFDKMNDQDRTSIHE 587
            .||||.|:..|..|::.|||..:.::..|.::.||||||||.|||:|.|||||||.:|.: ::.|
  Rat   459 NVAPRGVYVCGNTATSSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLE 522

  Fly   588 AMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSMTFSENVNLSEPILSRFDVLCVVKDEF 652
            ||||||||::|||:|.||.||.::||||||:||.|:.:.|.|||:.:...:|||||::.::.|..
  Rat   523 AMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKARTVSENLKMGSALLSRFDLVFILLDTP 587

  Fly   653 DPMQDQQLAKFVVH--------------SHMKHHPSE-------EEQPELEE----PQLKTVDEI 692
            :...|..|::.|:.              |.:....|.       .|:|..|.    |..|| |.|
  Rat   588 NEQHDHLLSEHVIAIRAGKQRAVSSATVSRVLSQDSNTSVLEVVSEKPLSERLKVAPGEKT-DPI 651

  Fly   693 PQDLLRQYIVYAKENIRPKLTNIDEDKIAKMYAQLRQESFATGSLPITVRHIESVIRMSEAHARM 757
            |..|||:||.||::.:.|:|:......:...|.:||::|...||.|||.|.:||:||::||.||:
  Rat   652 PHQLLRKYIGYARQYVHPRLSTEAAQALQDFYLELRKQSQRVGSSPITTRQLESLIRLTEARARL 716

  Fly   758 HLRENVMEADVSMAIRMMLES-------------FIEAQKFSVMKKMRSTFQKYLSFQKDHSE-- 807
            .|||...:.|....|.:|..|             |..:|..|.|.. |||.::::|.....:|
  Rat   717 ELREEATKEDAEDIIEIMKHSMLGTYSDEFGNLDFERSQHGSGMSN-RSTAKRFISALNSIAERT 780

  Fly   808 ----LLFFILRQL----------------TLDQLAYIRCKDGPGATHVEIM 838
                ..|..|||:                :|:...|: .|.||....::.|
  Rat   781 YNNIFQFHQLRQIAKELNIQVADFENFIGSLNDQGYL-LKKGPKIYQLQTM 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:372227	9/43 (21%)
		MCM_N	184..270	CDD:379644	20/109 (18%)
		MCM	276..780	CDD:214631	198/569 (35%)
Mcm8	NP_001099984.1	MCM_N	88..213	CDD:291233	23/135 (17%)
		Mcm2	129..827	CDD:224162	226/711 (32%)
		AAA	425..583	CDD:99707	80/158 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820