Protein Alignment Mcm2 and Mcm5

DIOPT Version :9

• Sequence 1: NP_477121.1
• Gene: Mcm2 / 40973
• FlyBaseID: FBgn0014861
• Length: 887
• Species: Drosophila melanogaster
• Sequence 2: XP_038953490.1
• Gene: Mcm5 / 291885
• RGDID: 1306616
• Length: 734
• Species: Rattus norvegicus
• Alignment Length: 673
• Identity: 221/673 - (32%)
• Similarity: 357/673 - (53%)
• Gaps: 71/673 - (10%)

  Fly   177 RTEIANRFQSFLRTF---VDERG-AYTYRDRIRRMCEQNMSSF--VVSYTDLANKEHVLAYFLPE 235
            ::.:..||:.|||.:   .|..| .:.|||.::|  ..|:..:  .|...|||:.:..||.:|.:
  Rat    28 KSHLQKRFKEFLRQYRVGTDRTGFTFKYRDELKR--HYNLGEYWIEVEMEDLASFDEELADYLYK 90

  Fly   236 APFQMLEIFDKVAK---DMVLSIFPTYERVTTEIHVRISELPLIEELRTFRKLHLNQLVRTLGVV 297
            .|.:.|::.::.||   |.|....|..:.:..:|.|.:........:|..:...::.||:..|::
  Rat    91 QPAEHLQLLEEAAKEVADEVTRPRPAGDELLQDIQVMLKSDASPSSIRILKSDMMSHLVKIPGII 155

  Fly   298 TATTGVLPQLSVIKYDCVKCGYVLGPFVQSQNTEIKPG--------SC-------PECQSTGPFS 347
            .:.:.|..:.:.|...|..|...|      .|..::||        .|       |:| ...|:.
  Rat   156 ISASAVRAKATRISIQCRSCHNTL------TNIAMRPGLEGYALPRKCNMDQAGRPKC-PLDPYF 213

  Fly   348 INMEQTLYRNYQKITLQESPGRIPAGRIPRSKDVILLADLCDQCKPGDELEVTGIYTNNYDGSLN 412
            |..::....::|.:.|||.|..:|.|.:||...:.....|||:..||:.:.:.|||:....| :|
  Rat   214 IMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIKKFG-MN 277

  Fly   413 TDQGFPVFATVIIANHVVV--------KDSKQVVQSLTDEDIATIQKLSKDPRIVERVVASMAPS 469
            ..:|.......|.::::.|        ...:....|::.::....::|:..|.|.|.|..|::||
  Rat   278 PSKGRDRVGVGIRSSYIRVLGIQVDTDGSGRSFAGSVSPQEEEEFRRLAALPNIYELVSRSVSPS 342

  Fly   470 IYGHDYIKRALALALFGGESKNPGEKHKVRGDINLLICGDPGTAKSQFLKYTEKVAPRAVFTTGQ 534
            |:|...:|:|:|..||||..|...:....|||||||:.|||||||||.||:.||.:|..|:|:|:
  Rat   343 IFGGMDMKKAIACLLFGGSRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGK 407

  Fly   535 GASAVGLTAYVRRNPVSREWTLEAGALVLADQGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKA 599
            |:||.||||.|.|:|.||.:.:|.||:||||.||..|||||||.:.||.:||||||||:|||:||
  Rat   408 GSSAAGLTASVIRDPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKA 472

  Fly   600 GIVTSLQARCTVIAAANPIGGRYDPSMTFSENVNLSEPILSRFDVLCVVKDEFDPMQDQQLAKFV 664
            ||.|:|.:||:|:||||.:.||:|.:.. .:|::....||||||::.:||||.:..:|..|||.|
  Rat   473 GITTTLNSRCSVLAAANSVFGRWDETKG-EDNIDFMPTILSRFDMIFIVKDEHNEERDMMLAKHV 536

  Fly   665 VHSHMKHHPSEEEQPELEEPQLKTVDEIPQDLLRQYIVYAKENIRPKLTNIDEDKIAKMYAQLR- 728
            :..|:    |...|.:..|      .||....::::|.|.:....|:|:....:|:...|..:|
  Rat   537 ITLHV----SALTQTQAVE------GEIDLAKMKKFIAYCRARCGPRLSAEAAEKLKNRYIIMRS 591

  Fly   729 ------QESFATGSLPITVRHIESVIRMSEAHARMHLRENVMEADVSMAIRMMLESFIEA----- 782
                  ::.....|:|||||.:|:::|::||.::|.|:....||||..|:|:...|.::|
  Rat   592 GARQHERDIDRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAALSGN 656

  Fly   783 ----QKFSVM--KKMRSTFQKYL 799
                :.|:..  ::|.|..:|.|
  Rat   657 LSGVEGFTTQEDQEMLSRIEKQL 679

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:372227
		MCM_N	184..270	CDD:379644	27/94 (29%)
		MCM	276..780	CDD:214631	187/533 (35%)
Mcm5	XP_038953490.1	MCM_N	32..129	CDD:405270	28/98 (29%)
		MCM	133..649	CDD:214631	187/534 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820