DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm2 and Mcm7

DIOPT Version :9

Sequence 1:	NP_477121.1	Gene:	Mcm2 / 40973	FlyBaseID:	FBgn0014861	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	NP_001004203.3	Gene:	Mcm7 / 288532	RGDID:	1303018	Length:	719	Species:	Rattus norvegicus

Alignment Length:	702	Identity:	228/702 - (32%)
Similarity:	368/702 - (52%)	Gaps:	113/702 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 RFQSFLRTFV--DERG--AYTYRDRIRRMCEQNMSSFVVSYTDLANKEHVLAYFLPEAPFQMLE- 242
            :.:.||:.|.  ||.|  .:.|..::..:..:...:..|...|:|..:       ||....:.|
  Rat    12 KVKKFLQEFYYDDELGKKQFKYGTQLVHLAHREQVALYVDLDDVAEDD-------PELVDSICEN 69

  Fly   243 --IFDKVAKDMVLSIFPTY---ERVTTEI-HVRISELPLIEE----------------------- 278
              .:.::..|:|..:.|.|   |.|..:: .|.|....::|:
  Rat    70 AKRYSRLFADVVQELLPEYKEKEVVNKDVLDVYIEHRLMMEQRSRDPGAVRNPQNQYPSELMRRF 134

  Fly   279 --------------LRTFRKLHLNQLVRTLGVVTATTGVLPQLSVIKYDCVKCGYVLGPFVQSQN 329
                          :|..|...:.:|:...|:||..:.|.|::.|..|.|.:||......:||.
  Rat   135 ELYFQGPSSSKPRVIREVRADSVGKLLTVRGIVTRVSEVKPRMVVATYTCDQCGAETYQPIQSP- 198

  Fly   330 TEIKPGSCP--ECQ---STGPFSINMEQTLYRNYQKITLQESPGRIPAGRIPRSKDVILLADLCD 389
            |.:....||  |||   |.|...:....:.:..:|::.:||...::|.|.||||..|:|..:...
  Rat   199 TFMPLIMCPSQECQTNRSGGRLYLQTRGSKFIKFQEMKIQEHSDQVPVGNIPRSITVVLEGENTR 263

  Fly   390 QCKPGDELEVTGIYTNNYDGSLNTDQGFPVFATVIIAN-----HVVVKDSKQVVQSLTDEDIATI 449
            ..:|||.:.||||:.    ..|.|  ||...|..:::.     |.|||.:|      :::|::..
  Rat   264 IAQPGDHVSVTGIFL----PVLRT--GFQQMAQGLLSETYLEAHRVVKMTK------SEDDVSGA 316

  Fly   450 QKLS-------KDPRIVERVVASMAPSIYGHDYIKRALALALFGGESKNPGEKHKVRGDINLLIC 507
            .:||       .:....|::.||:||.||||:.:|:||.|.|.||..::| :..|:||:|::.:.
  Rat   317 GELSAEELKQIAEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQSP-QGMKIRGNIHICLM 380

  Fly   508 GDPGTAKSQFLKYTEKVAPRAVFTTGQGASAVGLTAYVRRNPVSREWTLEAGALVLADQGVCLID 572
            ||||.||||.|.|.:::|||:.:|||:|:|.|||||.|.|:.||.|.|||.|||||||||||.||
  Rat   381 GDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCID 445

  Fly   573 EFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSMTFSENVNLSEP 637
            |||||.:.|||:|||.||||:|||:||||:|:|.|||:::|||||..|||:|..:..:|:.|...
  Rat   446 EFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAA 510

  Fly   638 ILSRFDVLCVVKDEFDPMQDQQLAKFV--VHSHMKHHPSEEEQPELEEPQLKTVDEIPQDLLRQY 700
            :|||||:|.:::|..|...|.:||:.:  ||.|.:..|::.|..:::             |:|:|
  Rat   511 LLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPAQFEPLDMK-------------LMRRY 562

  Fly   701 IVYAKENIRPKLTNIDEDKIAKMYAQLRQESFATGSLPIT-VRHIESVIRMSEAHARMHLRENVM 764
            |...:|. :|.:.:...|.|...|.::|:|:.|:.....| .|.:.:::|:|.|.||:.:.:.|.
  Rat   563 IAMCRER-QPTVPDSLADYITAAYVEMRREARASKDATYTSARTLLAILRLSTALARLRMVDIVE 626

  Fly   765 EADVSMAIRMMLESFIEAQKFSVMKKMRSTFQKYLSFQKDHSELLFFILRQL 816
            :.||:.|||:|     |..|.|::.:...|.:     .:..::::|..:|:|
  Rat   627 KEDVNEAIRLM-----EMSKDSLLGEKGQTAR-----TQRPADVIFATVREL 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:372227
		MCM_N	184..270	CDD:379644	20/96 (21%)
		MCM	276..780	CDD:214631	200/560 (36%)
Mcm7	NP_001004203.3	MCM_N	12..165	CDD:291233	25/159 (16%)
		MCM	145..641	CDD:214631	200/528 (38%)
		P-loop_NTPase	376..515	CDD:304359	84/138 (61%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820