DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mcm2 and mcm5

DIOPT Version :9

Sequence 1:NP_477121.1 Gene:Mcm2 / 40973 FlyBaseID:FBgn0014861 Length:887 Species:Drosophila melanogaster
Sequence 2:NP_848523.2 Gene:mcm5 / 286747 ZFINID:ZDB-GENE-021209-1 Length:736 Species:Danio rerio


Alignment Length:735 Identity:232/735 - (31%)
Similarity:380/735 - (51%) Gaps:91/735 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   177 RTEIANRFQSFLRTF---VDERG-AYTYRDRIRRMCEQNMSSFVVSYTDLANKEHVLAYFLPEAP 237
            |::|..:|:.|||.|   .|..| .|.|||.::|..........|...|||:.:..|:..|.:.|
Zfish    29 RSQIKKKFREFLRQFRVGTDRTGFTYKYRDELKRHYTLGEYWIEVEMEDLASFDEDLSDCLYKLP 93

  Fly   238 FQMLEIFDKVAK---DMVLSIFPTYERVTTEIHVRISELPLIEELRTFRKLHLNQLVRTLGVVTA 299
            .:.|.:.::.|:   |.|....|..|....:|.|.:........:|:.:...:::||:..|::.:
Zfish    94 SENLPLLEEAAQEVADEVTRPRPVGEETVQDIQVMLKSDAHPASIRSLKSEQVSRLVKIPGIIIS 158

  Fly   300 TTGVLPQLSVIKYDCVKCGYVLGPFVQSQNTEIKPG------------------SCPECQSTGPF 346
            :|.|..:.:.:...|..|..|:      .|..:.||                  .||    ..|:
Zfish   159 STAVRAKATRVCLQCRGCRAVI------SNIPLPPGLQGYALPRKCNTEQAGRVKCP----VDPY 213

  Fly   347 SINMEQTLYRNYQKITLQESPGRIPAGRIPRSKDVILLADLCDQCKPGDELEVTGIYTNN---YD 408
            .|..::.:..::|...|||:|..:|.|.:||...:.....|||:..||:.:.|.|||:..   ..
Zfish   214 FIIPDRCVCVDFQTQRLQEAPDAVPHGEMPRHMQLYCDRYLCDRVVPGNRVTVMGIYSIKKVAQT 278

  Fly   409 GSLNTDQGFPV-----FATVIIANHVVVKDSKQVVQSLTDEDIATIQKLSKDPRIVERVVASMAP 468
            .:...|:|..|     :..|:..:.......:....|::.::...::.|:..|.:.:.:..|:||
Zfish   279 KAKGRDKGTGVGIRSAYLRVVGIDVDTEGAGRGATGSVSPQEEEELRSLAASPSVYDSLARSLAP 343

  Fly   469 SIYGHDYIKRALALALFGGESKNPGEKHKVRGDINLLICGDPGTAKSQFLKYTEKVAPRAVFTTG 533
            ||||.|.:|:|:|..||||..|...:....|||||||:.|||||||||.||:.|:.:|..|:|:|
Zfish   344 SIYGSDDLKKAIACLLFGGSRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFVERCSPIGVYTSG 408

  Fly   534 QGASAVGLTAYVRRNPVSREWTLEAGALVLADQGVCLIDEFDKMNDQDRTSIHEAMEQQSISISK 598
            :|:||.||||.|.|:|.:|.:.:|.||:||||.||..|||||||.:.||.:||||||||:|||:|
Zfish   409 KGSSAAGLTASVLRDPTTRGFVMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAK 473

  Fly   599 AGIVTSLQARCTVIAAANPIGGRYDPSMTFSENVNLSEPILSRFDVLCVVKDEFDPMQDQQLAKF 663
            |||.|:|.:||:|:||||.:.||:|.:.. .:|::....||||||::.::||..|..:|..||:.
Zfish   474 AGITTTLNSRCSVLAAANSVFGRWDDTKG-EDNIDFMPTILSRFDMIFIIKDHHDQQRDMTLARH 537

  Fly   664 VVHSHMKHHPSEEEQPELEEPQLKTVDEIPQDLLRQYIVYAKENIRPKLTNIDEDKIAKMYAQLR 728
            |::.|:    |.:.|.|..|      .|||...|::||.|::....|:|:....:|:...|..:|
Zfish   538 VMNVHL----SAQTQTEGVE------GEIPLATLKKYIAYSRVKCGPRLSAAAAEKLKNRYVLMR 592

  Fly   729 -------QESFATGSLPITVRHIESVIRMSEAHARMHLRENVMEADVSMAIRMMLESFIEA---- 782
                   :|:....|:|||||.:|:|:|::|:.|:|.|:....|.:|..|:|:...|.::|    
Zfish   593 SGAKEHERETDRRVSIPITVRQLEAVVRIAESLAKMKLQPIAGEEEVDEALRLFQVSTLDAALSG 657

  Fly   783 -----QKFSVM--KKMRSTFQKYL-------SFQKDHSELLFFILRQL---TLDQLAYIRCKDGP 830
                 :.|:..  ::|.|..:|.|       |...:||.:..|..::.   .:.::.|:..:.| 
Zfish   658 SLSGVEGFTTQEDQEMISRIEKQLKRRFAIGSQVSEHSIIQDFAKQKYPEHAIQKVLYLMLRRG- 721

  Fly   831 GATHVEI---MERDLIERAK 847
                 |:   |:|.::.|.|
Zfish   722 -----ELQHRMQRKVLYRVK 736

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mcm2NP_477121.1 MCM2_N 59..166 CDD:372227
MCM_N 184..270 CDD:379644 27/92 (29%)
MCM 276..780 CDD:214631 186/536 (35%)
mcm5NP_848523.2 MCM_N 35..154 CDD:291233 30/118 (25%)
MCM 134..651 CDD:214631 186/537 (35%)
AAA 378..522 CDD:99707 82/144 (57%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1241
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D232729at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.820

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