DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mcm2 and MCM9

DIOPT Version :10

Sequence 1:NP_477121.1 Gene:Mcm2 / 40973 FlyBaseID:FBgn0014861 Length:887 Species:Drosophila melanogaster
Sequence 2:NP_060166.2 Gene:MCM9 / 254394 HGNCID:21484 Length:1143 Species:Homo sapiens


Alignment Length:618 Identity:212/618 - (34%)
Similarity:334/618 - (54%) Gaps:68/618 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   237 PFQMLEIFDKVAKDMVLSIF-----PTYERVTTEIHVRISELPLIEELRTFRKLHLNQLVRTLGV 296
            |.::|.|||...:...|:|.     |....:...:|.|||.||:..||   .:.|:.: .:.:|.
Human    62 PSEVLTIFDSALRRSALTILQSLSQPEAVSMKQNLHARISGLPVCPEL---VREHIPK-TKDVGH 122

  Fly   297 VTATTGVLPQLSVIK-------YDCVKCGYVLGPFV-----QSQNTEIKPGSCPECQS--TGPFS 347
            ..:.||.:.:.|::|       |.|.||.:|   ||     :...|..:|.|||..:|  :..|:
Human   123 FLSVTGTVIRTSLVKVLEFERDYMCNKCKHV---FVIKADFEQYYTFCRPSSCPSLESCDSSKFT 184

  Fly   348 ----INMEQTLYRNYQKITLQESPGRIPAGRIPRSKDVILLADLCDQCKPGDELEVTGIYTNNYD 408
                ::...|..|:||:|.:||...|:..|.||||..|||..||.|.||.||:|.:.||....:.
Human   185 CLSGLSSSPTRCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGIVMQRWK 249

  Fly   409 GSLNTDQGFPVFATVIIANHVVVKDSKQVVQSLTDEDIATIQK--------LSKDPRIVERVV-A 464
             ....|....| ..|:.||::.| :::|....:.||:   :||        ...||.....|: |
Human   250 -PFQQDVRCEV-EIVLKANYIQV-NNEQSSGIIMDEE---VQKEFEDFWEYYKSDPFAGRNVILA 308

  Fly   465 SMAPSIYGHDYIKRALALALFGGESKNPGEKHKVRGDINLLICGDPGTAKSQFLKYTEKVAPRAV 529
            |:.|.::|...:|.|:|:.|.||..:......:|||:.:||:.|||||.|||||||..|:.||:|
Human   309 SLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSV 373

  Fly   530 FTTGQGASAVGLTAYVRRNPVSREWTLEAGALVLADQGVCLIDEFDKMNDQDRTSIHEAMEQQSI 594
            .|||.|:::.|||....::  |.||.||||||||||.|:|.||||:.:.:.||||||||||||:|
Human   374 LTTGIGSTSAGLTVTAVKD--SGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTI 436

  Fly   595 SISKAGIVTSLQARCTVIAAANPIGGRYDPSMTFSENVNLSEPILSRFDVLCVVKDEFDPMQDQQ 659
            |::|||:|..|..|.|::||.|| .|:|||..:.|.|:.|..|:|||||::.|:.|..:...|:.
Human   437 SVAKAGLVCKLNTRTTILAATNP-KGQYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRI 500

  Fly   660 LAKFVVHSHMKHHPSEEEQPELEEPQLKTVDEIPQDLLRQYIVYAKENIRPKLTNIDEDKIAKMY 724
            ::.|::.:  |.:||:.|       :|.::::     ::.|....: |::|.|:::....:.:.|
Human   501 ISSFILEN--KGYPSKSE-------KLWSMEK-----MKTYFCLIR-NLQPTLSDVGNQVLLRYY 550

  Fly   725 AQLRQESFATGSLPITVRHIESVIRMSEAHARMHLRENVMEADVSMAIRMMLESFIEAQKFSVMK 789
             |::::|....:...|:|.:||:||::|||||:..|:.|...|....:.:|..|.........:.
Human   551 -QMQRQSDCRNAARTTIRLLESLIRLAEAHARLMFRDTVTLEDAITVVSVMESSMQGGALLGGVN 614

  Fly   790 KMRSTFQKYLSFQ-KDHSELLFFILRQLTLDQL 821
            .:.::|.:....| :...||   ||.:|.|..|
Human   615 ALHTSFPENPGEQYQRQCEL---ILEKLELQSL 644

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mcm2NP_477121.1 MCM2_N 59..166 CDD:403724
MCM_N 182..271 CDD:464206 10/38 (26%)
MCM 276..780 CDD:214631 189/530 (36%)
MCM9NP_060166.2 Mcm2 2..605 CDD:440854 203/574 (35%)
MCM9 305..603 CDD:350666 127/316 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 656..738
PTZ00449 <751..1113 CDD:185628
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 755..815
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 868..916
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 942..1011
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1063..1105
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.