DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm2 and mcm2

DIOPT Version :9

Sequence 1:	NP_477121.1	Gene:	Mcm2 / 40973	FlyBaseID:	FBgn0014861	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	NP_595477.1	Gene:	mcm2 / 2540620	PomBaseID:	SPBC4.04c	Length:	830	Species:	Schizosaccharomyces pombe

Alignment Length:	818	Identity:	424/818 - (51%)
Similarity:	557/818 - (68%)	Gaps:	43/818 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PSSPPPNTPSDAAERRDLRAAMTSPVGDFEPFENEDEILGDQTVRDEAEEEDGEELFGDNMENDY 68
            ||||||....:|||     |.:...:.|.     :.|.|       :.|:|:||:|||:.||.||
pombe    33 PSSPPPEFSDEAAE-----ALVEEDIEDL-----DGEAL-------DVEDEEGEDLFGEGMERDY 80

  Fly    69 RPMPELDHYDPALLDDEDDFSEMSQGDRFAAESEMRRR----DRAAGIHRDDRDLGFGQSDDED- 128
            :...|||.||...|||::|..|:..|.|.|.::.:|||    |.|||   ..:...|.|.:|:|
pombe    81 QQNLELDRYDIEELDDDNDLEELDIGARRAVDARLRRRDIELDAAAG---RTKPAAFLQDEDDDL 142

  Fly   129 --DVG---PRAKRRAGEKAA--VGEVEDTEMVESIENLEDTKGHSTKEWVSMLGPRTEIANRFQS 186
              ::|   .|.:.|..::.:  ||.::::..: .:|::.|.|..|..|||::...|..||..|::
pombe   143 DSNLGTGFTRHRHRIYDEYSPNVGALDESGEL-PLESIADVKADSIAEWVTLDPVRRTIAREFKN 206

  Fly   187 FLRTFVDERGAYTYRDRIRRMCEQNMSSFVVSYTDLANKEHVLAYFLPEAPFQMLEIFDKVAKDM 251
            ||..:.||.|...|.:|||.:.|.|..|.:|:|..|...:.:|||||..||..:..|||:||.:.
pombe   207 FLLEYTDENGTSVYGNRIRTLGEVNAESLMVNYAHLGESKPILAYFLANAPAPIFRIFDRVALEA 271

  Fly   252 VLSIFPTYERVTTEIHVRISELPLIEELRTFRKLHLNQLVRTLGVVTATTGVLPQLSVIKYDCVK 316
            .|..:|.|||:.::|||||:.||....||..|:.|||.|||..||||..||:.|||..|::.|.|
pombe   272 TLLHYPDYERIHSDIHVRITNLPTCFTLRDLRQSHLNCLVRVSGVVTRRTGLFPQLKYIRFTCTK 336

  Fly   317 CGYVLGPFVQSQNTEIKPGSCPECQSTGPFSINMEQTLYRNYQKITLQESPGRIPAGRIPRSKDV 381
            ||..||||.|..:.|:|...|..|.|.|||.||.|:|:|.|||:||||||||.:|:||:||.::|
pombe   337 CGATLGPFFQDSSVEVKISFCHNCSSRGPFVINSERTVYNNYQRITLQESPGTVPSGRLPRHREV 401

  Fly   382 ILLADLCDQCKPGDELEVTGIYTNNYDGSLNTDQGFPVFATVIIANHVVVKDSKQ------VVQS 440
            ||||||.|..|||:|::|||||.||:|.||||..|||||||:|.|||:...|...      .:..
pombe   402 ILLADLVDVAKPGEEIDVTGIYRNNFDASLNTKNGFPVFATIIEANHISQLDGSGNTDDDFSLSR 466

  Fly   441 LTDEDIATIQKLSKDPRIVERVVASMAPSIYGHDYIKRALALALFGGESKNPGEKHKVRGDINLL 505
            |||::...|:.|:|.|.|..|::||||||||||..||.|:|.|||||..||...|||:|||||:|
pombe   467 LTDDEEREIRALAKSPDIHNRIIASMAPSIYGHRSIKTAIAAALFGGVPKNINGKHKIRGDINVL 531

  Fly   506 ICGDPGTAKSQFLKYTEKVAPRAVFTTGQGASAVGLTAYVRRNPVSREWTLEAGALVLADQGVCL 570
            :.|||||||||||||.||.|.||||.||||||||||||.||::|::.|||||.|||||||:||||
pombe   532 LLGDPGTAKSQFLKYVEKTAHRAVFATGQGASAVGLTASVRKDPITNEWTLEGGALVLADKGVCL 596

  Fly   571 IDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSMTFSENVNLS 635
            |||||||||||||||||||||||||||||||||:||||||:|||||||||||:.::.|::||.|:
pombe   597 IDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTTLQARCTIIAAANPIGGRYNTTIPFNQNVELT 661

  Fly   636 EPILSRFDVLCVVKDEFDPMQDQQLAKFVVHSHMKHHPSEEEQPEL--EEPQLKTVD--EIPQDL 696
            ||||||||:|.||||..:|..|:|||.|||.||::.||:.:...::  :.|....:|  .|||||
pombe   662 EPILSRFDILQVVKDTVNPEIDEQLANFVVSSHIRSHPAFDPNMDVLKKVPTETGIDAKPIPQDL 726

  Fly   697 LRQYIVYAKENIRPKLTNIDEDKIAKMYAQLRQESFATGSLPITVRHIESVIRMSEAHARMHLRE 761
            ||:||.:|:|.:.|:|..:||:||:::|:.:|:||.||||.||||||:||.||:|||.|:|.|.|
pombe   727 LRKYIHFAREKVFPRLQQMDEEKISRLYSDMRRESLATGSYPITVRHLESAIRLSEAFAKMQLSE 791

  Fly   762 NVMEADVSMAIRMMLESFIEAQKFSVMKKMRSTFQKYL 799
            .|..:.:..||:::::||:.|||.||.:.:..||.|||
pombe   792 FVRPSHIDKAIQVIIDSFVNAQKMSVKRSLSRTFAKYL 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:372227	39/118 (33%)
		MCM_N	184..270	CDD:379644	36/85 (42%)
		MCM	276..780	CDD:214631	310/513 (60%)
mcm2	NP_595477.1	MCM2_N	42..187	CDD:289392	50/165 (30%)
		MCM_N	203..315	CDD:291233	49/111 (44%)
		MCM	295..810	CDD:214631	310/514 (60%)
		P-loop_NTPase	529..668	CDD:304359	112/138 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	326	1.000	Domainoid score	I216
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3325
Inparanoid	1	1.050	784	1.000	Inparanoid score	I74
OMA	1	1.010	-	-		QHG54431
OrthoFinder	1	1.000	-	-		FOG0004149
OrthoInspector	1	1.000	-	-		oto102168
orthoMCL	1	0.900	-	-		OOG6_101336
Panther	1	1.100	-	-	LDO	PTHR11630
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R692
SonicParanoid	1	1.000	-	-		X3415
TreeFam	1	0.960	-	-
	14	13.860